NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2019 · $710,671 — Summary. Hemoglobinopathies such as β-thalassemia and sickle cell disease are genetic disorders caused by mutations in the HBB gene that codes for the β-globin component of hemoglobin. Currently, the only gene therapy available for these prevalent hereditary diseases is based on transplantation of g…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Steven Michael Romanelli · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2019 · $37,153 — PROJECT SUMMARY The prevalence of obesity has reached pandemic levels with nearly 2 billion people worldwide considered overweight and one-third of that obese. Obesity is associated with an increased risk for type II diabetes, heart disease, and certain types of cancer which severely debilitates qua…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Ann Cornwall Collier · UNIVERSITY OF WASHINGTON · 2019 · $794,929 — The Targeted Long-acting Combination Antiretroviral Therapy (TLC-ART) Program has discovered a novel platform that can stabilize insoluble and soluble antiretroviral drugs together in a nanosuspension which provides long-acting (LA) plasma and cell concentrations in pre-clinical studies. The lead fo…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Evan Alexander Scott · NORTHWESTERN UNIVERSITY · 2019 · $685,339 — PROJECT SUMMARY Subunit vaccines combine immunodominant protein or peptide antigens from pathogens with select adjuvants, aiming to provide a more scalable, reproducible, low cost and rapid alternative to attenuated vaccines that contain live pathogens. Unfortunately, current subunit vaccines lack …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2019 · $267,708 — PROJECT SUMMARY This proposal aims to develop live-cell, multi-channel imaging tools that can visualize—continuously, and in real time—nanoparticle interactions with cellular components. We will focus on several different time windows, where early time periods will monitor nanoparticle-cell membran…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2019 · $692,621 — PROJECT SUMMARY - Research Project 3 Members of the filovirus genera Ebolavirus and Marburgvirus are HHS Tier 1 Category A priority pathogens that cause severe and often fatal hemorrhagic fever (HF) in humans and nonhuman primates (NHPs). There are presently no approved therapeutics for ebolavirus o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Yifan Cheng · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2019 · $292,895 — As a versatile structure determination technology, cryo-EM is an integrated part of the HARC Center. In the past funding cycle, the Cryo-EM Core has engaged in technology development of single-particle cryo-EM, and has made major contributions to the recent technological breakthroughs in single part…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Gretchen Mahler · STATE UNIVERSITY OF NY,BINGHAMTON · 2019 · $303,993 — PROJECT SUMMARY Nanomaterials are increasingly used in consumer products, processed food, and food packaging, and few studies have determined the consequences of nanoparticle ingestion. The ultimate goal of this work is to determine if and how ingested metal oxide nanoparticles alter microorganism p…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Joel Kaar · UNIVERSITY OF COLORADO · 2019 · $198,980 — SUMMARY The formation of amyloid fibrils due to protein aggregation represents a central step in the pathogenesis of many age-related diseases for which there are no current cures. At the core of this step is the misfolding of one or more key proteins, which is converted from a natively folded or un…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
GREGORY C GIBSON · GEORGIA INSTITUTE OF TECHNOLOGY · 2019 · $175,023 — Project Summary Over the past decade, the NIDDK IBDGC (Inflammatory Bowel Disease Genetics Consortium) has generated extraordinary datasets in support of genetic analysis of the onset, progression, and therapeutic response to Crohn's disease and ulcerative colitis. This Ancillary project will comple…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2019 · $87,299 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
John B Barnett · EXESALIBERO, INC. · 2019 · $102,161 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
JENNIFER A DOUDNA · UNIVERSITY OF CALIFORNIA BERKELEY · 2019 · $800,300 — PROJECT SUMMARY / ABSTRACT CRISPR-Cas9 has demonstrated incredible potential to provide clinical benefit, but the challenge of delivery currently hinders therapeutic use of genome editing in vivo. Use of viral vectors and lipid nanoparticles has established the viability of in vivo genome editing, b…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Mark Andrew Borden · UNIVERSITY OF COLORADO · 2019 · $352,275 — The development of new pharmaceuticals for the treatment of brain cancer and neurological disease has outpaced our ability to deliver them safely, largely due to the blood-brain barrier (BBB). Bypassing the BBB to access the brain parenchyma is often highly invasive, involving surgery to remove part…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Dmitri Simberg · UNIVERSITY OF COLORADO DENVER · 2019 · $343,881 — DESCRIPTION (provided by applicant): While having tremendous potential as a therapeutic tool, clinical use of engineered nanoparticles has also been associated with serious safety concerns. Following systemic injection, nanoparticles interact with blood proteins causing life-threating hypersens…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Elena Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $664,893 — Project Summary This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of macrophage-derived extracellular vesicles (EV), precursors of microcalcifications, contributing to the biomechanical instability of the vulnerable atheroscleroti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Pamela K Woodard · WASHINGTON UNIVERSITY · 2019 · $624,055 — PROJECT SUMMARY This proposal is a first-in-human trial of a newly developed nanoparticle PET radiotracer that targets the natriuretic peptide receptor C (NPR-C), with the long-term potential to help to determine which asymptomatic patients with carotid artery stenosis might require surgery. Our res…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Sangpil Yoon · UNIVERSITY OF NOTRE DAME · 2019 · $248,999 — Project Summary / Abstract Dr. Sangpil Yoon is a postdoctoral scholar at the Department of Biomedical Engineering at the University of Southern California (USC). He has developed an innovative technique for the intracellular delivery of macromolecules using high frequency ultrasound. Dr. Yoon is a p…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
David Lawrence Danley · PARABON NANOLABS, INC. · 2019 · $225,220 — PROJECT SUMMARY/ABSTRACT The human immune response to HIV-1 is complex with the virus demonstrating remarkable evasion mechanisms. Significant progress has recently been made in HIV vaccine development based on early-stage clinical trials and subsequent investigations into the nature of protective i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Fekadu Kassie · UNIVERSITY OF MINNESOTA · 2019 · $352,275 — PROJECT SUMMARY Lung cancer is the leading cause of cancer-related death in the United States. About 90% of lung cancer cases are associated with genetic/epigenetic changes induced by tobacco smoke (TS). Although all types of lung cells could be affected by TS, the effect on stem cells is particular…