Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
WILLIAM E. CARSON · OHIO STATE UNIVERSITY · 2019 · $543,192 — PROJECT SUMMARY RNA nanotechnology has progressed rapidly during the past several years. This nanotechnology includes the integration of multiple functional modules into one nanoparticle, of which the scaffolds, ligands, therapeutics, and regulators can be composed mainly or exclusively of RNA. We …
Marco Brotto · UNIVERSITY OF SOUTH FLORIDA · 2019 · $433,699 — Project Summary Diabetes is a leading cause of death in the US and worldwide with deleterious consequences to the musculoskeletal system. Regardless of glycemic control, diabetes in skeletal muscle manifests with altered metabolism leading to progressive skeletal muscle loss, functional decline, fas…
Mary Jane Thomassen · EAST CAROLINA UNIVERSITY · 2019 · $311,326 — DESCRIPTION (provided by applicant): Pulmonary granuloma formation is a key feature of sarcoidosis, a chronic disease of unknown etiology. Sarcoidosis has been linked to environmental risk factors (wood-burning stoves, fireplaces and firefighting) that favor carbon nanotube formation. We have shown …
GEORGE K. GITTES · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2019 · $374,150 — PROJECT SUMMARY AND RELEVANCE An ideal solution to the treatment or cure of diabetes mellitus would be the formation of new functioning β-cells from the patient’s own tissues, thereby avoiding the need for transplant immunosuppression. Abundant recent data has suggested that α-cells are a likely sou…
Clyde Jason Wright · UNIVERSITY OF COLORADO DENVER · 2019 · $490,696 — PROJECT SUMMARY Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and predicts poor pulmonary and neurodevelopmental outcomes. Despite the well-documented association between inflammation and BPD, no safe and effective anti-inflammatory therapies to prevent BP…
Monica Maki Burdick · OHIO UNIVERSITY ATHENS · 2019 · $428,636 — Abstract! Engineered nanomaterials (ENMs) are being increasingly used in industrial and biomedical applications. It is estimated that there are currently more than 1,800 nanomaterial-based products on the market, with more than 770 in the United States alone. This widespread use has raised concerns …
Runhua Runa Liu · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2019 · $204,188 — Project Summary Background: Triple-negative (estrogen receptor [ER]/progesterone receptor [PR]/human epidermal growth factor receptor 2 [HER2]-negative) breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Approximately 34% of patients with TNBC will experience distant recurrence wi…
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2019 · $382,600 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
WILLIAM M ATKINS · UNIVERSITY OF WASHINGTON · 2019 · $299,338 — Project Summary P-glycoprotein (P-gp) is an ATP-dependent efflux transporter that plays a critical role in drug and xenobiotic distribution, drug-drug interactions, and drug-nutrient interactions. Efforts to modulate P-gp activity to control cellular drug resistance or to modulate the action of exis…
Young-wook Jun · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2019 · $202,851 — ABSTRACT Monitoring dynamic protein-protein interactions (PPIs) in situ has been a topic of interest due to the importance of PPIs in cell signaling regulation and implications in therapeutic interventions. In this proposal, we introduce a new PPI method based on nanotechnology-assisted magnetic co-…
Reyad A Elbarbary · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2019 · $395,786 — Abstract Impaired or delayed fracture healing is a clinical problem that affects >1.5 million people in the US annually; obesity and associated type 2 diabetes (T2D) are significant and independent risk factors in this context. Nearly 34% of the US population is obese, and the number is projected to…
Barton F. Haynes · DUKE UNIVERSITY · 2019 · $1,844,691 — Project 1: Development of Nucleoside-Modified mRNAs Encoding Sequential HIV-1 Envelopes for Initiation of V3-glycan Neutralizing Antibody Lineages A major goal of HIV-1 vaccine development is to induce broadly neutralizing antibodies (bnAbs). This IPCAVD team has immunogens that can trigger unmutate…
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $3,396 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2019 · $459,749 — Abstract: The primary function of Omics Core is to provide members of the ULARC with the expertise, resources and facilities needed for metabolomic, proteomic and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment…
DONALD R GERECKE · RBHS-SCHOOL OF PUBLIC HEALTH · 2019 · $846,767 — Research Project 1. Vesicant-induced Skin Injury Key personnel: Donald Gerecke, Ph.D., Associate Professor, Rutgers University School of Pharmacy Jeffrey D. Laskin, Ph.D., Professor, Rutgers University School of Public Health Project Summary/Abstract Sulfur mustard (bis-2-chloroethyl sulfide, SM) an…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2024 · $1,189,190 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…
DAVID E CLEMENTS · HAWAII BIOTECH, INC. · 2024 · $203,325 — 7. Project Summary/Abstract The encephalitic New World alphaviruses (NWAVs), consisting of Eastern, Venezuelan and Western Equine Encephalitis Viruses (EEEV, VEEV and WEEV, respectively), are transmitted by mosquitoes through rodent or bird hosts and have caused significant periodic epizootic outbre…
ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $175,294 — ABSTRACT This is a fourth competitive renewal of our highly successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on bio…
John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2024 · $902,657 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…
DAVID E CLEMENTS · HAWAII BIOTECH, INC. · 2023 · $204,264 — 7. Project Summary/Abstract The encephalitic New World alphaviruses (NWAVs), consisting of Eastern, Venezuelan and Western Equine Encephalitis Viruses (EEEV, VEEV and WEEV, respectively), are transmitted by mosquitoes through rodent or bird hosts and have caused significant periodic epizootic outbre…