Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kristian Graugaard Andersen · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $642,550 — Project Summary - Project 2 The objective of Project 2 is to investigate the complex interplay of virus genetics and host immunity in determining epidemiology and outcome of infection with Lassa virus, Ebola virus, and SARS-CoV-2. Our central hypothesis is that both host and virus factors play key r…
F David Horgen · UNIVERSITY OF HAWAII AT MANOA · 2023 · $243,885 — ALTERATIONS AND RENOVATIONS SUMMARY Building on prior successes, partner institution Hawaii Pacific University (HPU) requests funds for renovations that will support the goals and objectives of the proposed INBRE V renewal. Prior INBRE grants have supported and inspired the development of the biomed…
Christopher F Basler · WASHINGTON UNIVERSITY · 2023 · $436,375 — RP02 Project Summary/Abstract for Contributions of Ebola and Marburg virus VP30 and VP24 proteins to viral RNA synthesis, assembly and egress Marburg virus (MARV) and Ebola virus (EBOV) are deadly emerging viruses of the filovirus family. Major gaps remain in our understanding as to how filoviral-fi…
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $738,644 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $1,926,969 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
Thomas William Geisbert · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2023 · $2,538,747 — Abstract Among viruses that cause disease in humans the henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), stand out for their impressive lethality. These viruses are among the most deadly human pathogens known to man with case fatality rates averaging about 75% for NiV. Significantly, there i…
Jason Douglas Salter · OYAGEN, INC. · 2023 · $299,000 — PROJECT SUMMARY This R43 proposal answers the call of the RFA PA-22-176 for assay development and chemical probe screening by addressing the unmet need for development of antiviral treatments for Ebola patients through an innovative high-content small molecule screen for antagonists of the Ebola VP4…
Cheng Huang · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $200,000 — PROJECT SUMMARY/ABSTRACT Several mammalian arenaviruses cause severe and fatal zoonotic diseases in humans, for which vaccines and treatments are very limited. Lassa virus (LASV) is the causative agent for Lassa fever (LF) that is currently endemic in Western Africa. Despite its importance to public…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $1,159,045 — PROJECT SUMMARY/ABSTRACT Nipah virus (NiV) causes febrile encephalitis and severe respiratory disease in humans with fatality rates as high as 100% in some outbreaks (average ~ 75% for outbreaks over the last decade). There are currently no licensed vaccines or therapies for combating NiV disease. N…
Gregg A Dean · COLORADO STATE UNIVERSITY · 2023 · $465,165 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $7,043,167 — OVERALL - Project Summary/Abstract Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%. The recent unprecedente…
Brian O'Shea · RAGIN' CAJUN FACILITIES, INC. · 2023 · $3,999,070 — University of Louisiana at Lafayette C06 Expansion of Macaque Breeding capacity at the New Iberia Research Center Abstract: As part of its expansion of its HIV/AIDS research program, the New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette (UL Lafayette) proposes to add maca…
Daniel S Chertow · CLINICAL CENTER · 2023 — Project 1: We previously developed a NHP ICU model in healthy (uninfected) NHPs. We have extended this model to included supportive care of animals infected with E.coli or K. pneumoniae. Among K. pneumoniae infected animals, we have completed initial bacterial dose-response studies and are now proc…
ROBERT A DAVEY · WASHINGTON UNIVERSITY · 2023 · $371,762 — Core C – Project Summary/Abstract Core C provides support for high biocontainment work to Research Projects 1 (RP01), RP02, RP03 and Core B. Work is prioritized through Core A. Core personnel bring unique expertise in molecular biology, cell biology and animal disease modeling for Ebola and Marburg …
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $2,890,889 — PROJECT SUMMARY/ABSTRACT – BSL-4 Evaluation Core (Core B) Among viruses that cause disease in humans the filoviruses, Ebolavirus and Marburgvirus, stand out for their impressive lethality. These viruses are the most deadly human pathogens known to man with reported case fatality rates of up to 90%…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2023 · $3,354,992 — Overall Project Summary/Abstract: Molecular mechanisms of filoviral-host interactions The family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), are zoonotic pathogens that cause outbreaks of severe human disease and require biosafety level 4 (BSL4) containment for study. Re…
Jay Kenneth Fisher · REDBUD LABS, INC. · 2023 · $983,642 — ABSTRACT We propose to develop a point-of-need system for differential molecular identification of filoviruses from syndromically similar infections. Our goal is to enable rapid, sensitive, and specific identification of quarantinable infections to reduce nosocomial risk and improve outbreak respons…
Junki Maruyama · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $249,000 — Lassa virus (LASV) is endemic in West African countries and causes outbreaks of LF annually. Although LASV is one of the most alarming pathogens from a public health perspective, there are few effective vaccines or therapeutics against LF. LASV must be handled at biosafety level 4 (BSL-4), due to …
Parizad Torabi-Parizi · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $108,714 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2023 · $1,826,105 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…