Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Mihaela Serpe · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2021 · $1,506,675 — The long-term goal of this project is to define molecular mechanisms that control synapse assembly, development and homeostasis. Drosophila NMJ is a glutamatergic synapse, similar in structure and physiology to mammalian central excitatory synapses. In flies each NMJ is unique and identifiable, syna…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2021 · $732,776 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $528,448 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Gonzalo Izaguirre · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $197,894 — Abstract Many human pathogenic viruses exploit the host-cell proteases of the proprotein convertase (PC) family for their own benefit. The proteolytic processing of viral surface proteins is a mechanism by which viruses regulate their infectivity. The crucial role of the proteolytic regulation of vi…
Maria Blasi · DUKE UNIVERSITY · 2021 · $402,500 — PROJECT ABSTRACT Acute kidney injury (AKI) is a common complication of Coronavirus disease 19 (COVID-19), affecting more than a third of patients hospitalized with COVID-19 and up to 90% of those requiring mechanical ventilation. Possible contributors to AKI in patients with COVID-19 include systemi…
Andrew Barrett Ward · SCRIPPS RESEARCH INSTITUTE, THE · 2021 · $621,250 — Abstract Structure-based vaccine design holds great promise for combatting viral pathogens that create substantial burdens on global health. For HIV, the soluble ectodomain of the envelope glycoprotein (Env), which is the primary target for neutralizing antibody responses, is the focal point for va…
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $528,448 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Samuel K Campos · UNIVERSITY OF ARIZONA · 2020 · $333,879 — Human papillomaviruses (HPVs) are the most common sexually transmitted infection. These viruses infect and replicate in mucosal and cutaneous epithelium, inducing cell proliferation as part of their replicative life cycle. High risk oncogenic HPVs caused over 500,000 cases of cervical cancer worldwi…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $495,230 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Gonzalo Izaguirre · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $252,845 — Abstract Many human pathogenic viruses exploit the host-cell proteases of the proprotein convertase (PC) family for their own benefit. The proteolytic processing of viral surface proteins is a mechanism by which viruses regulate their infectivity. The crucial role of the proteolytic regulation of vi…
Tianxin Yang · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2020 — DESCRIPTION (provided by applicant): A decade ago, (pro)renin receptor (PRR) was cloned as a new component of the renin-angiotensin system (RAS) with the capability to bind prorenin and renin to increase their catalytic activity. Soluble PRR (sPRR) is derived from the extracellular domai…
THOMAS H BUGGE · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2020 · $2,244,204 — The overall aim of this project is to understand the biochemistry, biology, and pathology of cell surface-associated proteolysis, with an emphasis on determining the contribution to the development, homeostasis, regeneration, and malignant transformation of oral tissues. Cell surface serine proteas…
Tianxin Yang · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2019 — DESCRIPTION (provided by applicant): A decade ago, (pro)renin receptor (PRR) was cloned as a new component of the renin-angiotensin system (RAS) with the capability to bind prorenin and renin to increase their catalytic activity. Soluble PRR (sPRR) is derived from the extracellular domai…
THOMAS H BUGGE · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2019 · $2,110,888 — The overall aim of this project is to understand the biochemistry, biology, and pathology of cell surface-associated proteolysis, with an emphasis on determining its contribution to the development, regeneration, and malignant transformation of oral tissues. Cell surface serine proteases as regulat…
SERGIO FAZIO · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $533,826 — Summary Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulatory protein that binds to the low-density lipoprotein receptor (LDLR), induces its degradation, and increases LDL-cholesterol (LDL-C) levels. Thus, PCSK9 is a therapeutic target to increase LDLR expression and reduce plasma L…
HENRY DANIELL · UNIVERSITY OF PENNSYLVANIA · 2019 · $726,730 — DESCRIPTION: Injectable biopharmaceuticals produced in current systems are prohibitively expensive and are not affordable for a large majority of the global population. Recent studies have shown that bioencapsulation of protein drugs in plant cells are protected in the stomach. Commensal microb…
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2019 · $566,573 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $971,268 — Anthrax toxin protective antigen protein (PA) binds to receptors on the surface of mammalian cells, is cleaved by cellular proteases, forms an oligomer, and transports two other toxin proteins, lethal factor (LF) or edema factor (EF) to the cytosol. EF is a potent calmodulin-dependent adenylyl cycla…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2019 · $426,871 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Michael P Hutchens · PORTLAND VA MEDICAL CENTER · 2024 — Acute cardiorenal syndrome (cardiorenal syndrome type 1, CRS1) frequently follows the most common cause of admission to a Veterans Health Administration inpatient facility, acute cardiovascular disease. Although CRS1 seems to self-resolve in most cases, development of chronic kidney disease often oc…