Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
GILL DIAMOND · TULANE UNIVERSITY OF LOUISIANA · 2023 · $764,413 — Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a life-threatening illness with multi-system involvement in a subset of infected individuals. Oral and nasopharyngeal (NP) epithelial cells express the SARS-CoV-2 receptor…
Shelli Farhadian · YALE UNIVERSITY · 2023 · $1,230,201 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Philippe Youkharibache · DIVISION OF BASIC SCIENCES - NCI · 2023 · $40,912 — A significant part of my recent research efforts is focused on studying self-association determinants of molecular systems as revealed by their structural symmetries at several levels: from proteins assemblies to their protein supersecondary structures constituents (protodomains) [Youkharibache 2019…
Sonja Best · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $482,755 — The SARS-CoV-2 global pandemic has a continuing demand for greater understanding of the mechanisms of disease and the development of therapeutics to complement success in vaccination. Several mouse models have emerged that can be used, albeit with limitations, as models of severe SARS-Cov2 infection…
Natalie Shaw · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $172,894 — We confirmed increased ACE2 mRNA and protein expression and functional activity (via a fluorometric assay) in SMCHD1 KO human placode cells. We are now conducting molecular and genomic studies, including RNA-seq, Hi-C, and SMCHD1 ChIP-seq, studies to investigate the precise mechanism underlying epig…
Peter Skene · SEATTLE CHILDREN'S HOSPITAL · 2023 · $815,639 — Abstract The immune system is composed of many heterogeneous cell types that respond in a synergistic manner to mount both immediate and long-lived immunity against pathogens. The complexity of the immune system necessitates an integrated view of multiple biological modalities to understand differen…
Swati S More · UNIVERSITY OF MINNESOTA · 2023 · $580,098 — ABSTRACT Angiotensin-converting enzyme (ACE) plays a well-established role in regulating blood pressure in the periphery. ACE is also expressed in the brain, with high levels in the striatonigral pathway formed by medium spiny projection neurons that express the Drd1 dopamine receptor (D1-MSNs). We …
REINHARD LAUBENBACHER · UNIVERSITY OF FLORIDA · 2023 · $762,062 — PROJECT SUMMARY/ABSTRACT A key feature of the COVID-19 infection is the vast inter-individual heterogeneity in the severity of the infection. The complex biological mechanisms that underlie this variability remain mostly obscure. We propose to provide a mechanistic understanding of this susceptibil…
Ralph S Baric · WASHINGTON UNIVERSITY · 2023 · $1,197,841 — Project Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that was first isolated in Wuhan China in December, 2019. SARS-CoV-2 is the cause of coronavirus disease 2019 (COVID-19), which is now a pandemic and has caused more than 1.3 mi…
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2023 · $815,811 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination reduces the risk of SARS-CoV-2 infection and severe disease, but almost half of hospitalized breakthrough cases are in immunocompromised individuals. HIV infection is an independent risk factor for severe COVID-19, hospitalization, and mortality. Immunoc…
Noam A Cohen · PHILADELPHIA VA MEDICAL CENTER · 2023 — ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximately 3.5% and a wide range of morbidity outcomes negatively impacted by pre-existing conditions. Given the prevalence of p…
Steven Van Dyken · WASHINGTON UNIVERSITY · 2023 · $194,584 — ABSTRACT Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and resultant coronavirus disease 2019 (COVID-19) has caused a global health crisis, surpassing 100 million infections in the United States. SARS- CoV-2 infections range from asymptomatic to respiratory failure and death, and can …
Xuyi Yue · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · 2023 · $177,500 — PROJECT SUMMARY The coronavirus disease2019 (COVID-19) pandemic is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). New COVID-19 cases and COVID-19 related deaths continue to rise rapidly and no effective drugs or vaccines are currently available…
GR Scott Budinger · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $742,194 — PROJECT SUMMARY This application directly stems from our recent publication in Nature in which we analyzed bronchoalveolar lavage (BAL) fluid from 88 patients with critical SARS-CoV-2 pneumonia using a combination of flow cytometry, bulk transcriptomic profiling of flow sorted alveolar macrophages a…
Spyridon Stavrou · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2023 · $199,375 — A viral pathogen associated with severe pneumonia was recently identified as the cause of a global pandemic that has resulted in the death of over two million people. This viral pathogen was later classified as a coronavirus that was subsequently named Severe Acute Respiratory Syndrome Coronavirus 2…
Monica Kraft · UNIVERSITY OF ARIZONA · 2023 · $1,431,641 — In this AADCRC program renewal, we will focus on three critical and understudied innate immune factors and how they impact viral infections in asthma: the anionic phospholipids of surfactant (palmitoyl- oleoyl-phosphatidylglycerol, POPG, and phosphatidylinositol, PI), Toll interacting protein (Tolli…
Kyeong-Ok Chang · KANSAS STATE UNIVERSITY · 2023 · $735,037 — PROJECT SUMMARY Human coronaviruses generally cause the common cold, a mild upper respiratory illness, however, global outbreaks of new human coronavirus infections with severe respiratory disease have periodically emerged from animals. These include Severe Acute Respiratory coronavirus (SARS-CoV), …
Xiaofeng Li · ABBRATECH, INC. · 2023 · $296,100 — Abstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even a…
Alexander Minchev Tsankov · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $126,750 — PROJECT SUMMARY COVID-19 disease, caused by the novel coronavirus SARS-CoV-2, is a global health threat due to its rapid spread, morbidity, and mortality. It is estimated that at least 25% of severe COVID-19 disease survivors experience persistent respiratory complications. This underscores the need…
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $369,431 — The overarching goal of this project is to determine the role of angiotensin converting enzyme 2 (ACE2) in the diabetic gut, how it impacts hyperglycemia and glycemic variability, and thus contributes to the pathogenesis of diabetic retinopathy (DR). The protective arm of the renin angiotensin syste…