023 FDA Appendix in Support 1

Pfizer Documents (PHMPT/FDA)

Pfizer Bla Submission

Pfizer Court Documents

110

Document text

Exhibit A 
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Exhibit B 
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~12pages
~289page
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5.3.5
Expanded sections for the Phase1 / 2/ 3 study are below
~31pages
~48pages
~2033pages
~1 page
~3611pages
~1584pages
~ 2pages
~ 3697pages
~ 14pagesIndex not being provided for 
section5.3.1 (wouldneed 
disclosure review first)
~240 pages(~20 
journal articles)~38 pagesDetails of 5.3.5 
are provided 
below
There are 2 
studies, shown 
here.  The record
descriptions for 
each follow
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That is the end of the first study
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See below for the Phase I/II study
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Exhibit C 
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From: Aaron Siri
To: Enlow, Courtney D. (CIV)
Cc: Elizabeth Brehm ; Gabrielle Palmer
Subject: [EXTERNAL] RE: Public Health and Medical Professionals for Transparency v. FDA,, 4:41-cv-01058-P (N.D. Tex.
2021)
Date: Thursday, November 04, 2021 4:06:13 PM
Attachments: image001.png
image002.png
image003.png
image004.png
Also, CFRs for site 1085 which is on page 33 of the PDF.
From: Aaron Siri 
Sent: Thursday, November 4, 2021 12:58 PM
To: Enlow, Courtney D. (CIV) <[email protected]>
Cc: Elizabeth Brehm <[email protected]>; Gabrielle Palmer <[email protected]>
Subject: RE: Public Health and Medical Professionals for Transparency v. FDA,, 4:41-cv-01058-P (N.D.
Tex. 2021)
Hi Courtney,
Nice meeting yesterday. Based on our follow-up preliminary discussion with our client earlier today,
they would like to know if the FDA will produce the following items by November 17:
1.Pdf page 27: CRFs for site 1055
2.Pdf page 31: CRFs for site 1081
3.Pdf page 38: CRFs for site 1096
4.Pdf page 46: CRFs for site 1128
5.Pdf page 10: Program Files/SAS files. They want 3 to 4 SAS files as a sample, in the first  instance, 
so that they client can assess whether it would like to prioritize the complete universe  of SAS 
files.
6.Pdf page 1: 5.2 - Tabular Listing of all Clinical Studies
7.Pdf page 1: 4 – Nonclinical Study Reports
8.Pdf page 2: 5.3.6 - Reports of Postmarketing Experience
9.Pdf page 3: 16.1.1 - Protocol and/or Amendment, and specifically, Final Analysis Interim  
Independent Oversight Committees
10.Pdf page 6: Under the Analysis Datasets (ADaM), the Analysis Data Reviewers Guide, Analysis  
Dataset Definition, and Analysis Dataset Definition Stylesheet
11.Pdf page 11: Tabulation Datasets
If we can get agreement on producing these limited items as noted, we can advise as much in our
joint letter and that we are continuing to discuss a production schedule for the remaining data and
information.
Please let us know if the FDA will agree to their proposal.
Thanks,
Aaron
From: Enlow, Courtney D. (CIV) < [email protected] > 
Sent: Thursday, November 4, 2021 11:07 AM
To: Gabrielle Palmer < [email protected] >
Cc: Aaron Siri < [email protected] >; Elizabeth Brehm < [email protected] >
Subject: RE: Public Health and Medical Professionals for Transparency v. FDA,, 4:41-cv-01058-P (N.D.
Tex. 2021)
App110Case 4:21-cv-01058-P   Document 23   Filed 12/06/21    Page 110 of 110   PageID 349Case 4:21-cv-01058-P   Document 23   Filed 12/06/21    Page 110 of 110   PageID 349