Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
BRIAN KENNETH KAY · TANGO BIOSCIENCES, INC. · 2022 · $222,933 — Antibodies are incredibly powerful tools in basic research and clinical testing because they offer exquisite specificity and affinity in detecting proteins of interest in complex mixtures. They have played a particularly useful role in monitoring post-translational modifications, such as phosphoryla…
Yidong Bai · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2022 · $193,750 — 1 Populations at higher risk of severe disease from COVID-19 are the elderly and those with metabolic 2 syndromes, the populations known for compromised mitochondrial function. In addition, the most common 3 symptoms in hospitalized COVID patients are shortness of breath and fatigue, indicating de…
Kelly Keisen Lee · UNIVERSITY OF WASHINGTON · 2022 · $597,847 — Protein-mediated membrane fusion is essential for a multitude of fundamental biological processes. Despite intensive study, at present we have a limited mechanistic understanding of how fusion protein machinery manipulates lipid membranes in order to induce their fusion. This lack of knowledge is pa…
Masashi Tabuchi · CASE WESTERN RESERVE UNIVERSITY · 2022 · $386,030 — Project Summary/Abstract The idea that information processing depends on neuronal firing rate (rate coding) has long been a central dogma in neurobiology. However, other non-canonical coding schemes (temporal and “analog” codes) have been proposed to carry meaningful information and be more computat…
James B Munro · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 · $502,500 — SUMMARY Influenza A virus (IAV) hemagglutinin (HA) is the canonical example of a class-I viral fusion protein, and thus provides an ideal model system for understanding the fusion mechanisms of many different viruses. Numerous other viral envelope glycoproteins, including the SARS-CoV-2 spike, are b…
Chandan Guha · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $582,293 — Abstract Radiation-Induced Immune Dysfunction (RIID) is a critical component of both acute and delayed effects of radiation exposure, which causes a multi-organ failure (MOF) syndrome, operationally divided based upon timing of clinical manifestations, as acute radiation syndrome (ARS) and delayed e…
Ann Venables Griffith · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2022 · $232,500 — Summary The novel coronavirus, SARS-CoV-2, and the resulting Coronavirus Infectious Disease 2019 (COVID-19) has caused more than 500,000 deaths in the US. COVID-19 causes increased mortality and morbidity in patients over 65 years of age relative to younger patients. This is consistent with well-cha…
DANA P ASCHERMAN · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $207,958 — The current SARS-CoV-2 pandemic has had devastating consequences, with more than 110,000,000 cases and 2,400,000 deaths worldwide. Beyond the direct effects of SARS-CoV-2 infection, much of the morbidity and mortality stems from dysregulated activation of the immune system that culminates in systemi…
CHRISTOPHER M WATERS · UNIVERSITY OF KENTUCKY · 2022 · $522,331 — Acute lung injury and its more severe form, acute respiratory distress syndrome (ARDS), are devastating illnesses with high rates of incidence and mortality. Patients with acute lung injury are typically provided supplemental oxygen using positive pressure mechanical ventilation, but this can lead t…
Wendy PrudhommeOMeara · DUKE UNIVERSITY · 2022 · $243,050 — In many developing countries, the Covid-19 pandemic has had limited direct impact, including Kenya, which as of 5 March 2021, has recorded only 107,329 cases and 1,870 deaths owing to Covid19. Although this limited clinical impact is in part the result of strict travel and movement restrictions and …
Gillian Fitz · VANDERBILT UNIVERSITY · 2022 · $31,986 — PROJECT SUMMARY/ABSTRACT In Eukarya, actin-based protrusions such as filopodia, stereocilia, and microvilli, support a wide variety of cellular functions including motility, mechanosensation, and nutrient absorption. Formation of a surface protrusion involves deformation of the plasma membrane, and…
SAMUEL JEREMY PLEASURE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $623,479 — PROJECT SUMMARY COVID-19 is associated with a growing number of peripheral and central nervous system complications. It has become clear that a subset of these syndromes, including acute necrotizing encephalopathy, steroid- responsive encephalitis and Guillain-Barré syndrome, are likely due to dire…
Franklin Caval-Holme · BOSTON CHILDREN'S HOSPITAL · 2022 · $67,174 — PROJECT SUMMARY/ABSTRACT When faced with a visual scene, the brain encodes both image detail and the scene’s overall intensity, measured as irradiance. Encoding irradiance is critical for circadian regulation, pupil constriction, and image vision, among other important functions. A canonical feature…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $2,018,073 — Abstract. The UNC Center for Excellence in SARS-CoV2 Serologic Research uses basic and applied research strategies to improve our understanding of the molecular and cellular mechanisms driving serological and humoral immune responses after SARS-CoV2 infection. Our overall goals are to 1) characteriz…
Lanying Du · GEORGIA STATE UNIVERSITY · 2022 · $742,199 — Abstract Traditional strategies of vaccine development suffer from long-term and costly manufacture, and as a result, often fail to respond rapidly to newly emerging and reemerging infectious diseases. By contrast, messenger RNA (mRNA) is rising as a new technology platform to develop vaccines “on d…
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2022 — The current COVID-19 pandemic is one of the most disruptive events in human history, caused by the SARS- CoV-2 virus, member of the coronavirus family that uses angiotensin converting enzyme 2 (ACE2), a transmembrane carboxypeptidase identified as a member of the renin-angiotensin system (RAS) as an…
JULIE M. OVERBAUGH · FRED HUTCHINSON CANCER CENTER · 2022 · $123,360 — The ongoing global pandemic of the novel SARS-CoV-2 coronavirus (CoV) presents an urgent need for development of effective preventative and treatment therapies. The viral-host cell fusion (S) protein spike is a prime target for such therapies owing to its critical role in the virus lifecycle. The S …
Alexis Noel Ross · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2022 · $26,664 — PROJECT SUMMARY/ABSTRACT The mechanisms that control hepatic stellate cell (HSC) migration during liver development and regeneration are not well understood. This knowledge gap has hindered the generation of new therapies and the improvement of patient outcome for various developmental disorders su…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2022 · $845,848 — The development of a safe and effective vaccine and to improve treatment strategies aiming to reduce/eliminate the virus reservoir are currently at the forefront of our research. Based on our recognition of the fundamental mechanisms of mRNA expression, exemplified by the regulated ex…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2022 · $588,522 — While antibody-based therapeutics have emerged as a major component in cancer treatment, the generation of antibodies to important targets such as cell surface receptors and ion channels remains difficult. These proteins contain buried functional sites that are often unreachable by cl…