Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
RICK B MEEKER · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $388,750 — HIV infection of the nervous system results in chronic infection, inflammation and cognitive decline in many patients with no effective treatments. Inflammation appears early in the disease process and causes progressive neural damage due, in part, to factors released by activated microglia and macr…
James J Kobie · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $841,228 — PROJECT SUMMARY SARS-CoV-2 has infected over 138 million people and resulted in over 2.8 million deaths so far, with the expectation the pandemic will continue for many more months, and the virus will persist endemically for years, exacerbated by emerging variants of concern (VoC). Although several …
HENRIQUE Prado VON GERSDORFF · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $375,943 — PROJECT SUMMARY The major goal of this Administrative Supplement is to determine the changes in neuronal excitability and synaptic strength within the mammalian auditory brainstem during Alzheimer’s disease (AD) and during age related hearing loss (ARHL). We will use well established transgenic mous…
Timothy O'Connor · ROCKEFELLER UNIVERSITY · 2022 · $7,019,416 — Project Summary/Abstract Rockefeller University is a unique institution: with only 70 Heads of Laboratories, the faculty have received 3 Nobel prizes in Medicine in the last 10 years and 5 (plus 1 in chemistry) in the last 21 years, along with appointment of 18 faculty as HHMI investigators and 29 t…
Jane R Taylor · YALE UNIVERSITY · 2022 · $330,750 — Drug-associated conditioned stimuli (CS), or cues, contribute to both the progression and persistence of addiction. We hypothesize, as have others, that blocking reconsolidation of cocaine-cue memories could prevent cue-induced relapse. Reconsolidation is a process whereby reactivation of a memory r…
MANOJ K PATEL · UNIVERSITY OF VIRGINIA · 2022 · $399,015 — Epilepsy is a major economic and personal burden for the American public, affecting over 3 million Americans (1-2% of the population) with over 200,000 new cases diagnosed each year. There is no cure for epilepsy. Seizures can only be suppressed using antiepileptic drugs. Unfortunately, these drugs …
WEI CHEN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $234,000 — Abstract The long-term goal of our research is to develop effective therapies against SARS-CoV-2-elicited disease Covid-19. SARS-CoV-2 spike (S) protein binds to its cognate receptor, angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine proteas…
Magnus Adrian Gero Hoffmann · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2022 · $421,000 — Project Summary/Abstract The COVID-19 pandemic represents the 3rd outbreak caused by zoonotic transmission of a beta-coronavirus (beta-CoV) in the last 20 years. Hence there is an urgent need for new vaccine strategies to control the ongoing pandemic and prevent future CoV outbreaks. mRNA vaccines h…
Peter Palese · ROCKEFELLER UNIVERSITY · 2022 · $130,823 — Abstract Given the uncontrolled spread of SARS-CoV-2 and the devastating impact on public health, therapeutic interventions are urgently needed for disease control. Indeed, several biotech and academic groups are currently focusing their efforts on the isolation and clinical development of monoclona…
Joana Almaca · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 · $383,750 — ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is still the most common cause of mortality in COVID-19 patien…
Steve J Smith · SOUTH DAKOTA SCHOOL OF MINES AND TECHN'Y · 2022 · $413,479 — Project Summary Tumor metastasis accounts for 90% of cancer-associated mortality. Epithelial-mesenchymal transition (EMT) of cancer cells provides the cancer cells with strong migratory-invasive abilities, and more recently, to mediate the development of chemoresistance, which is linked to cancer st…
Sarah E. Millar · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $748,027 — Project Summary/Abstract The COVID-19 pandemic has produced a global health and economic crisis. While the pandemic is gradually being lessened by mass vaccinations, full control of this disaster is hampered by several ongoing problems including: (i) resistance or poor access to vaccination; (ii) em…
Mark L Baccei · UNIVERSITY OF CINCINNATI · 2022 · $461,894 — Project Summary/Abstract Long-term potentiation (LTP) of primary afferent synapses onto spinal projection neurons (PNs) has been linked to increased pain sensitivity. The timing rules controlling the generation of LTP in adult PNs can be persistently relaxed by neonatal tissue damage, which likely …
TIMOTHY A HAYSTEAD · EYDIS BIO, INC. · 2022 · $284,707 — PROJECT SUMMARY/ABSTRACT The recent pandemic of novel coronavirus, COVID-19, has had a devastating effect on the health and well-being of individuals across the globe, including over 3.1 million confirmed infected so far, and a monumental impact on global healthcare systems and economies at large. I…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2022 · $4,251,842 — West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Devel…
Mariano Juan Kanamori Nishimura · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 · $777,784 — PROJECT SUMMARY/ABSTRACT LatiNET will use a multilevel social network model to examine how SARS-CoV-2 misinformation and Conspiracy Theory (CT) messages are shared across five settings (friends, family, work, health service and influencers), impacting Latinx vaccine hesitancy. Social networks are se…
Amir Kol · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $196,510 — This R21 proposes to fill a major scientific gap by investigating a new therapeutic approach for multisystem inflammatory syndrome in children (MIS-C) using an innovative and clinically relevant feline model. We propose to test a novel multi-pronged therapeutic paradigm targeting viral replication, …
ALBERTO ASCHERIO · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2022 · $483,619 — PROJECT SUMMARY The highest priority recommended by NINDS for clinical Parkinson’s research is to define “the features and natural history of prodromal Parkinson disease (PPD), including the events that underlie phenoconversion to clinically manifest PD, and biomarkers or other determinants of prodr…
MANUEL R AMIEVA · STANFORD UNIVERSITY · 2022 · $1,511,551 — Stanford/UNC Biomimetic U19 Research Center PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW Infectious diseases continue to pervasively afflict global health and socioeconomic stability despite substantial prevention and treatment initiatives. Respiratory and gastrointestinal pathogens rank amongst the m…
Robyn S. Klein · WASHINGTON UNIVERSITY · 2022 · $1,181,250 — PROJECT SUMMARY/ABSTRACT Viral infections are now recognized as risk factors for diseases of progressive pathological forgetting, supporting a new paradigm in neuroimmunology whereby innate immune molecules that function as modulators of a variety of normal CNS functions induce neurodegenerative dis…