Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
AMIN S GHABRIAL · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2019 · $335,807 — Ghabrial – Project Summary To build a functional vascular system, a network of endothelial tubes must be generated through a combination of vasculogenesis and angiogenesis. During sprouting angiogenesis, endothelial tip cells lead the outgrowth of new branches. Tip cells anastomose with other tip ce…
Kelly Keisen Lee · UNIVERSITY OF WASHINGTON · 2019 · $396,951 — Enveloped viruses use specialized protein machinery to fuse their membrane with the membrane of host cells and deliver their genetic material for replication. In influenza virus, the trimeric hemagglutinin (HA) glycoprotein spike is responsible for host cell attachment and membrane fusion. The seque…
Helen E Scharfman · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · 2019 · $404,250 — ABSTRACT It has been suggested that neuronal hyperexcitability is an important characteristic in Alzheimer’s disease (AD) because it contributes to the impairment in memory and increasing levels of amyloid β (Aβ) that characterize the disease. Using animal models of AD neuropathology we suggest tha…
MATTHEW C GIBSON · STOWERS INSTITUTE FOR MEDICAL RESEARCH · 2019 · $290,400 — DESCRIPTION (provided by applicant): Mitotic Rounding and Planar Spindle Alignment in Proliferating Epithelia Project Summary During development and homeostasis of multicellular animals, adherent layers of proliferating epithelial cells provide the spatial and structural contet essential for ne…
VADIM BOLSHAKOV · MCLEAN HOSPITAL · 2019 · $454,383 — DESCRIPTION (provided by applicant): The synaptic, neuronal and neural network mechanisms driving anxiety-like behaviors are not completely understood. Transient Receptor Potential channels (TRPC), belonging to the TRPC1/4/5 subfamily, are abundant in the brain areas implicated in control of in…
Michael-Christopher Keogh · EPICYPHER, INC. · 2019 · $259,086 — PROJECT SUMMARY Alterations in chromatin regulators are associated with diverse human pathologies. The ability to quantitatively assess these factors in healthy and diseased cells is essential to accelerate the development of therapeutics targeting epigenetic regulation (a growing area of study, wi…
LUKAS K TAMM · UNIVERSITY OF VIRGINIA · 2019 · $562,219 — PROJECT SUMMARY Membrane fusion, mediated by viral spike glycoproteins, is a key process in the infection cycle of all enveloped human and animal viruses. The overall goal of this project is to understand the molecular mechanisms of Ebola and human immunodeficiency virus entry by membrane fusion, by…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $953,984 — Over the past fiscal year, we have performed studies on three viral pathogens causing respiratory disease in humans, Nipah virus, influenza virus and Middle East Respiratory Syndrome coronavirus (MERS-CoV). (1) To develop animal disease (end host) and persistence (reservoir host) models: We have d…
John Mascola · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $3,639,529 — During the past year, the Virology Core has collaborated with other intramural NIAID labs to develop a MERS-CoV Spike protein subunit vaccine. A vaccine of adjuvanted MERS-CoV Spike protein subunit vaccine confers complete protection from MERS-CoV disease in alpaca and results in reduced and delayed…
KENNETH Stephen KOSIK · WEILL MEDICAL COLL OF CORNELL UNIV · 2019 · $296,063 — PROJECT SUMMARY/ABSTRACT — PROJECT 2 Many unknown pathogenic steps lie between normal tau protein in a healthy neuron and the cellular dysfunction that occurs as a result of tau uptake and aggregation. The aims address two emerging facets of the pathobiology: the mechanism of tau uptake in neur…
Julius N. Fobil · UNIVERSITY OF GHANA · 2020 · $199,975 — DESCRIPTION (provided by applicant): The overall objective of The West Africa-Michigan CHARTER II for GEOHealth is to build upon long- standing, extensive occupational and environmental health (OEH) research and training collaborations between academic and government partner institutions in Gha…
Julius N. Fobil · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2019 · $266,613 — DESCRIPTION (provided by applicant): The overall objective of The West Africa-Michigan CHARTER II for GEOHealth is to build upon long- standing, extensive occupational and environmental health (OEH) research and training collaborations between academic and government partner institutions in Gha…
Julius N. Fobil · UNIVERSITY OF GHANA · 2019 · $113,386 — DESCRIPTION (provided by applicant): The overall objective of The West Africa-Michigan CHARTER II for GEOHealth is to build upon long- standing, extensive occupational and environmental health (OEH) research and training collaborations between academic and government partner institutions in Gha…
Eric Jeffrey Topol · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $6,005,620 — PROJECT SUMMARY / ABSTRACT The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and informatics/analytics fosters a multi-dimensional understan…
Erica Ollmann Saphire · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2024 · $274,500 — PROJECT SUMMARY/ABSTRACT Vaccines are the greatest bang for our public health buck, yet vaccine development is still sometimes hit or miss. Recent efforts with SARS-CoV-2 demonstrated that acceleration of vaccine programs is possible, especially when supported by prior studies characterizing success…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2024 · $250,000 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
Jarrod Mousa · FLORIDA STATE UNIVERSITY · 2024 · $682,008 — While vaccines are available for SARS-CoV-2, influenza virus, and RSV, and our laboratory has advanced mAbs and vaccines for hMPV, there has been a lack of research on parainfluenza virus (PIV) disease prevention and treatment, despite being the second highest cause of acute lower respiratory infect…
Matthew D Cain · WASHINGTON UNIVERSITY · 2024 · $464,714 — PROJECT SUMMARY/ABSTRACT Viral infections are now recognized as risk factors for diseases of progressive pathological forgetting, supporting a new paradigm in neuroimmunology whereby innate immune molecules that function as modulators of a variety of normal CNS functions induce neurodegenerative dis…
Arnab Kumar Ghosh · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $84,750 — Program Summary I am an early-stage investigator and recent KL2 scholar who has used econometric and spatiotemporal meth- ods to examine the propagation of C-19 in vulnerable populations. The focus of this R03 is to build on this work to examine the interaction between two devastating public health …
Jason Edward Shoemaker · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $194,425 — ABSTRACT Respiratory viruses, such as influenza and SARS-CoV-2, interact with distinct molecular pathways in human cells to promote virus replication and alter immune activity. When considering patient cohort variability, morbidity and mortality are often higher for women than men for select influen…