Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Larissa A. Shimoda · JOHNS HOPKINS UNIVERSITY · 2024 · $718,982 — PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a severely debilitating disease with no cure. Morphometric studies revealed that the development of pulmonary hypertension is associated with robust structural remodeling of the small pulmonary arteries, characterized by thickening of the end…
Avinash Das Sahu · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $217,810 — PROJECT SUMMARY Avinash D Sahu, Ph.D., is a computational biologist whose overarching career goal is to solve longstanding problems in cancer immunology and translational precision oncology using artificial intelligence (AI) and to devise new therapeutic strategies for late-stage cancer patients. En…
Michael Andrew Schumacher · CHILDREN'S HOSPITAL OF LOS ANGELES · 2024 · $157,540 — PROJECT SUMMARY Deep crypt secretory (DCS) cells are an understudied lineage of secretory cells residing in the colonic crypt base with unknown roles in colitis. In preliminary data, I show that DCS cells express a class of proteins known as host defense peptides (HDPs) that can influence key epithe…
Alka Dev · DARTMOUTH COLLEGE · 2024 · $136,350 — PROJECT SUMMARY (ABSTRACT) People with disabilities experience pregnancy at the same rate as people without disabilities but have disproportionately higher rates of adverse outcomes including pregnancy, labor and delivery complications, severe maternal morbidity, maternal death, preterm birth, still…
SUSAN THOMAS LOVETT · BRANDEIS UNIVERSITY · 2024 · $504,582 — Project Summary Replication fork repair is essential for cell survival and stability of genetic material. In humans, inefficiency of repair is associated with cancer proneness, neurological, immunological, developmental defects and premature aging. For microbial pathogens, the ability to repair DNA …
Matthias Gromeier · DUKE UNIVERSITY · 2024 · $358,773 — Priming of antitumor immunity relies on a specialized subset of conventional Dendritic Cells (cDC1s), CD103+ DCs, that have unique capabilities of trafficking tumor antigens to lymph nodes for cross-presentation. The critical role of cDC1s in cancer immune surveillance make them highly coveted targe…
Hongchao Guo · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $249,000 — PROJECT SUMMARY This proposal describes a five-year career development program to prepare Dr. Hongchao Guo for a career as an independent investigator. This program will build on Dr. Guo’s background as a molecular stem cell biologist by providing him expertise in bioinformatics, secretomics, and dr…
Fernando Francisco Gonzalez · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $460,447 — PROJECT SUMMARY/ABSTRACT Neonatal stroke is an important cause of death and disability, and diagnosis is often delayed. There is insufficient knowledge regarding repair mechanisms that occur in response to focal ischemia-reperfusion injury that is the most common cause of early stroke. Angiogenesis,…
KWANHA YU · BAYLOR COLLEGE OF MEDICINE · 2024 · $152,274 — Glioma is the most common and deadly disease affecting the CNS. Current projections suggest 22,000 new cases annually, of which 13,000 will be Glioblastoma Multiforme, which is universally fatal. Despite over 60 years of research, there have been no significant improvements to patient outcome. More …
Nattachai Srisawat · CHULALONGKORN UNIVERSITY · 2024 · $137,229 — Leptospirosis is a potentially life-threatening zoonosis with protean manifestations and a leading cause of acute febrile illness (AFI) in the tropics. The acute phase of leptospirosis can trigger a systemic inflammatory response, leading to multiorgan failure, including liver failure, acute kidney …
Alison Katherine Conlin · SWEDISH MEDICAL CENTER, FIRST HILL · 2024 · $2,632,282 — In 2013, the Pacific Cancer Research Consortium (PCRC) was created to bring clinical trials and cancer care delivery research to community cancer treatment centers in the Western United States as an NCI Community Oncology Research Program (NCORP) Community Site. Under a multiple PI/PD structure, the…
Christine L Larson · UNIVERSITY OF WISCONSIN MILWAUKEE · 2024 · $713,411 — PROJECT ABSTRACT Trauma is common and increases risk for a host of negative health outcomes, most notably posttraumatic stress disorder (PTSD). Given the potential harmful sequelae of trauma exposure, it is crucial to identify acute post-trauma risk factors that predict chronic PTSD. Moreover, urban…
Dan E Arking · JOHNS HOPKINS UNIVERSITY · 2024 · $245,625 — Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. Many aging-related diseases have a mitochondrial (MT) component, with studies highlighting associations with cardiovascular disease,…
Catherine A Blish · STANFORD UNIVERSITY · 2024 · $815,573 — ABSTRACT Antiretroviral treatment (ART) for HIV infection effectively blocks viral replication, but fails to eradicate the virus, which can be a source of persistent inflammation. The pathways by which chronic, treated HIV infection drives inflammation are poorly defined, particularly in children an…
Jose R Conejo-Garcia · DUKE UNIVERSITY · 2024 · $367,057 — Abstract Aggressive malignant progression and spreading has limited a clear understanding of the pathophysiology of SCLC. The overarching goal of this “bedside to bench” project is to elucidate the role of inter-metastatic divergence in therapeutic resistance in small cell lung cancer (SCLC), with a…
Joseph Antony Cafazzo · YALE UNIVERSITY · 2024 · $542,296 — PROJECT SUMMARY/ABSTRACT In sub-Saharan Africa, heart failure (HF), a clinical syndrome that causes multiple debilitating symptoms and results in poor health-related quality of life, has a 34% 1-year mortality rate, the highest of any region globally. Major care gaps and sociodemographic disparities…
JAMES K CHEN · STANFORD UNIVERSITY · 2024 · $625,036 — Developmental biology is now both a molecular and systems-level science. Forward- and reverse-genetic technologies have identified individual genes that regulate tissue formation and contribute to their oncogenic transformation later in life. High-throughput sequencing has revealed the “omic” featur…
Manfred Boehm · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $658,626 — Brain microvascular ischemic disease is a common cause of leukoencephalopathy, leading to cognitive impairment, dementia, and stroke. CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most frequent mendelian cause of cerebral small vessel dis…
NIKOLA P PAVLETICH · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $672,595 — Genetic instability is a hallmark of cancer. The cell has evolved an intricate set of pathways that sense and repair DNA damage, which is an inevitable consequence of cellular metabolism and the environment. Failure of a repair pathway, due to either overwhelming DNA damage or pathway inactivation b…
Mariano A Loza Coll · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · 2024 · $147,500 — PROJECT SUMMARY Several master regulator (MR) genes have been characterized in tissue stem cells across organs and species. However, they remain poor candidates for therapeutic manipulation because they are highly pleiotropic, affecting hundreds of targets and operating across many organ systems. Th…