Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
ANDREY ZINCHUK · YALE UNIVERSITY · 2024 · $172,260 — Candidate. My goal is to become an independent physician-scientist who merges physiology and patient-ori- ented research methods to personalize care for patients with obstructive sleep apnea (OSA). My training as an engineer and a doctor in Pulmonary, Critical Care and Sleep Medicine (PCCSM), comple…
Paul L. Auer · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $703,426 — Project Summary With age, dividing cells acquire DNA mutations. A small number of these somatic mutations confer a selective advantage leading to a clonal proliferation of cells harboring the somatic mutation. In blood, this process is termed ‘clonal hematopoiesis’. These mutations include both poin…
Benjamin Greenbaum · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $617,031 — PROJECT SUMMARY Transcriptional dysregulation in tumors can induce the abundant expression of repetitive elements in cancerous cells compared to normal tissues, where they are often transcriptionally silent. Such transcripts have been associated with better outcomes to cancer immunotherapies, as the…
YONG XU · BAYLOR COLLEGE OF MEDICINE · 2024 · $601,556 — PROJECT SUMMARY Regular physical activity is a powerful intervention that reduces obesity and confers protection against obesity-associated metabolic diseases. The mechanisms responsible are incompletely understood but are likely to extend beyond activity-associated increases in energy expenditure a…
Daolin Tang · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $353,971 — Abstract Ferroptosis is a recently recognized form of regulated cell death driven by lipid peroxidation. It is an emerging field in cancer biology, and the detailed molecular regulators of ferroptosis are largely unknown. We recently demonstrated that upregulation of metallothionein (MT)-1G express…
Stefano Tarantini · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $181,250 — PROJECT SUMMARY/ABSTRACT Cognitive impairment associated with Alzheimer’s disease and Related Dementias (ADRD) and aging has emerged as one of the major public health challenges of our time. Recent clinical studies, as well as those in animal models, support that preservation of cognitive health de…
Melissa Ramirez · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $120,767 — Project Summary/Abstract This proposal focuses on the synergy of experiments and computations in (1) understanding fundamental reactivity in organic and organometallic transformations and (2) enabling reaction design for the discovery of methods for enantioselective spirocycle synthesis and radical…
Alexander Russell Lucas · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $123,519 — 1 PROJECT SUMMARY 2 A primary goal of this K01 proposal is to equip the candidate, Dr. Alexander Lucas, with the expertise to become 3 an independent investigator who is able to utilize state-of-the-art imaging techniques to evaluate subclinical 4 outcomes that predict future cardiovascular (CV) …
PERRY E BICKEL · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $519,551 — Project Abstract/Summary The rising prevalence of obesity and type 2 diabetes threatens to limit human healthspan by increasing the risks for cancer and cardiometabolic disease and to impose overwhelming economic burdens. New therapeutic strategies are urgently needed. Since the discovery of functio…
Takuto Greco Chiba · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $119,857 — PROJECT SUMMARY/ ABSTRACT A dire consequence of acute kidney injury (AKI) is a dramatically increased risk to develop chronic kidney disease (CKD). CKD accounts for 6.7% of Medicare expenses. Understanding the mechanisms by which AKI progresses to CKD is essential for developing therapies, for which…
GIDON S FELSEN · UNIVERSITY OF COLORADO DENVER · 2024 · $332,868 — PROJECT SUMMARY (ABSTRACT) Our long-term goal is to elucidate the systems and circuits, within and across brain regions, responsible for decision making. The objective of this proposal is to examine the neural circuit basis for how, in the face of sensory uncertainty, perceptual decisions are adapti…
Amy Dunn · JACKSON LABORATORY · 2024 · $849,854 — PROJECT SUMMARY Alzheimer’s disease is the most common cause of dementia in the elderly, but there are a number of other related dementias that exhibit substantial overlap in the behavioral, cognitive, and neuropathological manifestations of the disease. In fact, the majority of dementia cases likel…
Bo Li · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $386,817 — Project Summary/Abstract Cancer immunotherapy has achieved remarkable clinical success treating late-stage tumors, yet the response rates remain low and the side effects are often severe. Designing effective immunotherapies relies on accurate identification of tumor-reactive T cells. This is an extr…
Rene Opavsky · UNIVERSITY OF FLORIDA · 2024 · $58,098 — PROJECT SUMMARY Project title: Dnmt3b activities in mouse development DNA methylation is an epigenetic modification involved in the transcriptional regulation of genes involved in development and differentiation, and its deregulation contributes to human pathogenesis. It is catalyzed by the family o…
Yong Lu · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $369,383 — Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large established tumors. Unexpectedly, we found that these T cells promoted killing of antigen-loss-variants (ALVs) in vivo and preve…
FARROKH DEHDASHTI · WASHINGTON UNIVERSITY · 2024 · $595,711 — ABSTRACT Approximately 70% of breast cancers (BCs) are estrogen receptor (ER) positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-). Endocrine therapy (ET) reduces recurrence risk and improves survival for many in this group. However, despite standard of care and adjuvant ET, …
Dina Katabi · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $103,072 — PROJECT SUMMARY Chronic itch affects 13% of the population and is associated with over $90 billion in annual population- expenditures in the US. It has a profound negative impact on quality of life, and is often as debilitating as chronic pain. Yet, there are currently no FDA-approved treatments for…
Hala Galal El-Nahal · DUKE UNIVERSITY · 2024 · $41,436 — PROJECT SUMMARY The claustrum is a narrow, subcortical sheet of gray matter with interconnections across the cerebral cortex. Its irregular shape and deep location make it difficult to study with classical neurophysiological techniques. Recent genetic technologies such as optogenetics provide new ho…
Corey S Cutler · DANA-FARBER CANCER INST · 2024 · $2,508,066 — Summary Chronic GVHD (cGVHD) is the major cause of late morbidity, mortality and compromised organ function after allogeneic hematopoietic stem cell transplant (HCT). It can affect essentially all organs and tissues, including the lungs, where the disease is termed Bronchiolitis Obliterans Syndrome …
Bogdan Bintu · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $395,000 — Project Summary/Abstract Understanding the mechanisms of gene and chromatin regulation and their roles within a multicellular organism has relevance across many disciples such as synthetic biology, medicine, developmental biology and neuroscience 1–3. Large-scale efforts of the genomics community h…