Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Jessie P Buckley · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $554,037 — Abstract Low bone mineral density (BMD) during adolescence is associated with fractures in adolescence and adulthood as well as increased risk of osteoporosis, a chronic bone disease affecting more than 10 million older adults in the U.S. The majority of Americans are exposed to perfluoroalkyl subst…
Chu-Young Kim · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $317,200 — The overarching goal of our research program is to elucidate how nature produces polyether natural products. Polyethers are a subgroup of polyketide natural products and, as a class, they possess a wide range of useful activities, including antibacterial, antifungal, and anticancer properties. Howev…
Michael P Jankowski · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $475,508 — Abstract: While great deal is understood about mechanisms of sensory transduction from the skin, relatively little is known about this process from the muscles. As peripheral injuries resulting from repetitive ischemic/reperfusion (I/R) are a major health issue that affects millions of people in the…
James A Bankson · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $1 — PROJECT SUMMARY/ABSTRACT Head and neck squamous cell carcinoma (HNSCC) remains a leading cause of cancer deaths worldwide. Genotoxic agents, including radiation therapy (RT) and cisplatin (CDDP), are treatments that damage cellular DNA. RT and CDDP are the current standard of care in multiple solid …
Carl Ola Landgren · HOAG MEMORIAL HOSPITAL PRESBYTERIAN · 2024 · $560,238 — Project Summary / Abstract Multiple myeloma is a plasma cell neoplasm with poor prognosis but promising future treatment. Current measurements of myeloma disease burden are suboptimal, and this limits clinical care. We have completed a first-in-human trial of CD38-targeted immunoPET with the radiola…
Junsung Woo · BAYLOR COLLEGE OF MEDICINE · 2024 · $608,297 — Summary Astrocytes are the most abundant type of glial cell in the brain, playing vital roles in all facets of brain physiology. Given their central role in brain function, astrocytes have been implicated in a variety of psychiatric disorders including autism, anxiety, schizophrenia, depression, and…
Elisa J Gordon · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $241,318 — PROJECT SUMMARY/ABSTRACT Due to the organ shortage, more than 15,000 patients with end-stage liver disease (ESLD) are waiting for a life-saving liver transplant (LT) in the US, but fewer than 50% of waitlisted patients will go on to receive a LT.1 As a result, more than 2,000 LT waitlisted patients…
Sourav Bandyopadhyay · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $942,785 — PROJECT SUMMARY Our general strategy is to take advantage of novel tools and methodologies that we have developed during our first two CTD^2 funding periods– more specifically pioneering and applying CRISPR based technologies to aid the discovery and characterization of novel cancer targets and thei…
Tomomi Ichinose · WAYNE STATE UNIVERSITY · 2024 · $453,021 — Abstract Detection of moving objects is a retinal function which is crucial for an animal's survival. Multiple neurons and neural networks in the retina have been identified as critical players in this task, including starburst amacrine cells (SACs) and direction-selective ganglion cells (DSGCs), wh…
William Douglas Cress · PONCE SCHOOL OF MEDICINE · 2024 · $486,917 — Non-Hispanic black (NHB) and Hispanic/Latino (H/L) women in the United States (US) have higher probabilities of breast cancer-related death than non-Hispanic white (NHW) women. H/L women from the Caribbean (C-H/L, Puerto Rican, Cuban and Dominican) and black H/L are at an even higher risk of death t…
Irene Cortes-Puch · EICOSIS, LLC · 2024 · $2,141,943 — Summary/Abstract EicOsis is developing a first-in-class analgesic with efficacy against neuropathic pain that will replace and dose spare opioids and thus prevent opioid use disorders (OUDs). The target of the small molecule inhibitor EC5026 is the soluble epoxide hydrolase, a master regulatory enzy…
Paul Michael Arnaboldi · BIOPEPTIDES, INC. · 2024 · $971,664 — Babesia microti is a parasite that is transmitted by the same species of ticks that transmit Lyme disease. It is the causative agent of babesiosis, a disease with a wide array of clinical presentations that can range from an asymptomatic carrier state in some otherwise healthy individuals to causing…
Sapun H Parekh · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $203,610 — ABSTRACT Melanoma is the fifth most common cancer in the US with almost 100,000 cases estimated for 2023. Late-stage disease has a five-year survival of just 30%, resulting in almost 8,000 deaths in the US alone. When detected early, melanoma has a survival rate of 99%; however, a widely adopted scr…
Zhongren Zhou · PRE-CANCER DIAGNOSIS, LLC · 2024 · $398,738 — Summary The incidence of esophageal adenocarcinoma (EAC) has increased 600-700% in North America since the 1980s. EAC only has 18-22% of an overall 5-year survival rate because most patients are discovered at an advanced stage. The single major risk factor for the development of EAC is Barrett’s eso…
Dinesh S. Rao · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2024 · $580,298 — PROJECT SUMMARY/ ABSTRACT Protein-RNA interactions underlie an important and understudied component of gene regulation. RNA-binding proteins carry out numerous functions relating to the production, splicing, processing, and stability of mRNA molecules. A few years ago, we discovered that the oncofet…
James P Herman · UNIVERSITY OF CINCINNATI · 2024 · $578,180 — Summary Traumatic stress exposure elicits behavioral and physiological responses that can compromise health and well-being, generating brain and bodily changes that can intrude on appropriate emotional regulation. Numerous disease states, most notably post-traumatic stress disorder, share behavioral…
Brandon del Pozo · RHODE ISLAND HOSPITAL · 2024 · $162,397 — Abstract Text This timely and significant K01 award will provide the PI, Dr. del Pozo, with the training and expertise necessary to achieve his long-term goal of becoming a leading investigator of the health outcomes of policing in relation to substance use disorders. Drug overdose deaths have reach…
William Kester Nash · NATIONAL PARTNERSHIP/ENVIRONMNTL/TECH/ED · 2024 · $1,002,953 — The Partnership for Environmental Technology Education (PETE) submits this proposal on behalf of the Community College for Health and Safety Training (CCCHST) serving Department of Energy (DOE) environmental restoration and waste management sites at: Oak Ridge Operations, TN; Portsmouth Site, OH; Sa…
Leomar Y Ballester · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $260,634 — Project Summary/Abstract Primary and metastatic central nervous system tumors (CNS) are associated with a high degree of morbidity and mortality. There is a need for new and more effective strategies for diagnosing, treating and monitoring patients with primary and metastatic CNS tumors. Methodologi…
Markus Schober · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $468,096 — SUMMARY Mutations that activate proto-oncogenes or inactivate tumor suppressor genes are the root causes of tumor initiation, but recent genomic analyses also detect these mutations in many cells of healthy tissues. These data and classic skin carcinogenesis studies suggest that mutations in proto-o…