Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Brianna Fernandez · UNIVERSITY OF COLORADO · 2024 · $40,782 — PROJECT SUMMARY Cell-cycle exit can be either transient (quiescence) or permanent (senescence), and these different states are thought to have distinct molecular characteristics. Further, quiescence itself is not a single homogeneous state as cells that remain quiescent for longer durations of time…
David Scott Wilson · JOHNS HOPKINS UNIVERSITY · 2024 · $491,250 — 1. Abstract: The number of patients with autoimmunity and other antigen-specific immunoregulatory disorders is increasing worldwide at a rate of 4 to 8% per annum. Current therapies for autoimmunity only treat disease symptoms and are systemically immunosuppressive, resulting in an increased risk of…
Nicole Franziska Steinmetz · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $354,119 — Summary This R01 renewal application is focused on triple negative breast cancer (TNBC), which is an aggressive life- threatening disease with poor prognosis and increased likelihood of recurrence and distant metastasis. Advances in cancer immunotherapy have demonstrated that modulation of the patie…
MONICA A. DRISCOLL · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $612,568 — Healthy aging of the brain is highly dependent upon a range of protein quality control systems, and such quality control capacity is often disrupted in neurodegenerative disease. Recently it has come to light that diseased neurons can transfer toxic products, such as aggregated proteins, to neighbor…
Michael Kyba · UNIVERSITY OF MINNESOTA · 2024 · $435,293 — Abstract FSHD affects over 25,000 individuals in the United States. It is the third most common muscular dystrophy by incidence but may be the most common by prevalence (Orphanet, 2008). The DNA lesion associated with this disease is a contraction within a series of 3.3 kb repeats (D4Z4 repeats) nea…
JODI Kathleen MARANCHIE · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $438,296 — ABSTRACT Although RCC is typically classified as an immunogenic tumor, recent profiling studies instead suggest that presence of CD8+ TIL in this form of cancer is an indicator of poor prognosis. These findings emphasize the importance of appreciating immune context/immune cell networking in the tum…
Brian R Meckes · UNIVERSITY OF NORTH TEXAS · 2024 · $359,614 — Summary Statement An evolving extracellular mechanical landscape accompanies the progression of multiple diseases including cancer, pulmonary fibrosis, and hypertension. While the influence of stiffening tissue on gene expression, cell migration, and phenotype is well established, how these changes …
Peter C. Harris · MAYO CLINIC ROCHESTER · 2024 · $675,412 — Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that results in progressive renal insufficiency and often kidney failure and accounts for ~5% of US kidney transplant and dialysis patients. ADPKD is phenotypically and genetically heterogeneous with seven genes now …
Craig T. Jordan · UNIVERSITY OF COLORADO DENVER · 2024 · $884,768 — Summary This proposal is focused on the development of improved therapies for acute myeloid leukemia (AML). The central premise of our all our work is that AML is driven by a biologically distinct leukemia stem cell (LSC) population. While the conceptual importance of targeting leukemic disease at i…
Anahita Bassir Nia · YALE UNIVERSITY · 2024 · $155,444 — ABSTRACT There is an urgent need to develop novel pharmacological treatment for alcohol use disorder (AUD). Recently, psychedelic compounds have attracted great attention in treatment of different psychiatric disorders following their reported fast-acting and long-lasting effects. Preliminary eviden…
Keiran Smalley · UNIVERSITY OF FLORIDA · 2024 · $678,605 — Project Summary-Abstract Tumor microenvironment (TME) consists of many cell types that co-exist to promote tumor progression. Most cancer therapeutics are designed to target one molecule in one defined cell type. For example, vemurafenib (BRAF inhibitor) kills melanoma cells through targeting mutate…
Kyunghee Koh · THOMAS JEFFERSON UNIVERSITY · 2024 · $234,000 — PROJECT SUMMARY Frontotemporal dementia (FTD) is a neurodegenerative disease that belongs to a group of Alzheimer’s disease and related dementias (AD/ADRD) and is one of the most common dementias for people under 60. Our internal circadian clock controls numerous critical biological processes, inclu…
KATHRYN J MOORE · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $757,945 — SUMMARY In atherosclerotic cardiovascular disease (ASCVD), chronic inflammation is a major risk factor that remains unaddressed by currently approved therapies. Existing therapies aimed at curbing ASCVD target lipid metabolic pathways, and many patients continue to be at high risk of cardiovascular …
Stacey Kathryn Ogden · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $500,500 — PROJECT SUMMARY The evolutionarily conserved Sonic Hedgehog (SHH) signaling pathway governs tissue morphogenesis during development and contributes to tissue homeostasis in adults. Alteration of pathway activity drives developmental disorders including Holoprosencephaly (HPE), Pallister-Hall Syndrom…
Kevin Thomas Nead · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $258,561 — PROJECT SUMMARY Studies in healthy individuals have shown that acquired DNA mutations are surprisingly common in normal- appearing tissues. Clonal hematopoiesis (CH) mutations are acquired mutations in the blood present in the majority of older individuals. CH mutations are also frequent among indiv…
Lori A. Setton · WASHINGTON UNIVERSITY · 2024 · $514,885 — Intervertebral disc (IVD) degeneration is one of the greatest contributors to low back pain, yet how the IVD can generate pain remains poorly understood. To date, our knowledge of “cross-talk” between degenerating IVD and sensory nerves involved in transmitting pain is limited to findings of altered…
Natalia E. Morone · BOSTON MEDICAL CENTER · 2024 · $121,371 — Over the past 17 years Dr. Natalia Morone established her research career in patient-oriented research (POR) and integrative nonpharmacological interventions to treat chronic pain, particularly mindfulness interventions for chronic low back pain (cLBP). Her research portfolio also extends into mindf…
Meghan H Puglia · UNIVERSITY OF VIRGINIA · 2024 · $207,919 — Project Summary Current gold-standard diagnostic techniques for Autism Spectrum Disorder (ASD) rely on behavioral observation, and diagnosis is often not conferred until after age 4. This delay is unfortunate, because early intervention can drastically improve outcomes. Given the rapid and sweeping…
THOMAS C SPRAGUE · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2024 · $356,385 — PROJECT SUMMARY When looking for a red ladybug in a bush, our attention may be efficiently guided by the red color among the green leaves. If, instead, finding a green caterpillar is our goal, the same red color would need to be ignored, and instead a moving leaf should guide our search. Searching f…
Ambrose H Wong · YALE UNIVERSITY · 2024 · $126,932 — PROJECT SUMMARY/ABSTRACT This award is a four-year plan to support Ambrose Wong, MD, MSEd, an emergency physician, in his transition towards an independent research career that focuses on dissemination and implementation of services for mental health crises in general, non-psychiatric emergency set…