Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Muredach P Reilly · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $647,099 — Despite effective LDL-C therapies, cardiovascular disease (CVD) risk remains a major unmet clinical need. We and others have identified >300 loci for coronary artery disease (CAD). Genes that function in vascular smooth muscle cells (SMC) are causal at several loci yet the causal genes at most loci …
Catherine Ann Burrows · UNIVERSITY OF MINNESOTA · 2024 · $126,724 — PROJECT SUMMARY/ABSTRACT Screening tools for autism spectrum disorder (ASD) show poor predictive performance in practice, particularly for females, which may arise due to sex-related measurement bias of screening questionnaires, and lack of precision in capturing the variability in early symptom pro…
Ann M Decker · RESEARCH TRIANGLE INSTITUTE · 2024 · $120,166 — Abstract Chronic pain is one of the leading health problems worldwide. Opioids have served as gold standard for treating moderate to severe pain. However, opioids possess serious adverse effects that limit their use in clinics. Therefore there is an unmet need for alternative effective and non-addic…
PAUL H GOLDSPINK · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $199,875 — Project Summary/Abstract The production of functional proteins is a multistep process whereby newly synthesized polypeptides are enzymatically processed, folded, and assembled into oligomeric complexes. Key maturation processes occur co-translationally by coupling mRNA translation and nascent protei…
FRANK S HODI · DANA-FARBER CANCER INST · 2024 · $1,838,130 — Summary Because cancer immunotherapy constitutes one of the most transformative therapeutic movements over the history of cancer treatment, there are now hundreds, if not thousands, of ongoing clinical trials in this field. Despite the remarkable success for a subset of patients, there are substanti…
Weiping Tang · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $394,661 — Abstract Targeted protein degradation by chimeric molecules has emerged as a novel therapeutic modality. The bifunctional chimeric molecules usually have one end binding to the protein of interest (POI) and the other end directing the ternary complex towards the degradation in proteasome or lysosome…
TONIA S REX · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $477,794 — Each year approximately 3 million United States citizens incur traumatic brain injury (TBI). An additional 50,000 United States citizens derive permanent vision loss from direct ocular trauma. Both brain and ocular trauma can involve the optic nerve causing traumatic optic neuropathy (TON) even in t…
Diane S Krause · YALE UNIVERSITY · 2024 · $669,741 — (PLEASE KEEP IN WORD, DO NOT PDF) Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Abstract Fate specification is a fundamental aspect of hematopoietic stem and progenitor cell biology. The proposed studies are focus…
FANYIN MENG · RLR VA MEDICAL CENTER · 2024 — Alcoholic liver disease (ALD) is one of the most common forms of chronic liver injury in the United States. Chronic ethanol consumption results in toxic metabolites in the liver and increases endothelial senescence and dysfunction leading to inflammation and liver damage. Aging is linked with the se…
Amanda M Brandow · MEDICAL COLLEGE OF WISCONSIN · 2024 · $569,267 — PROJECT SUMMARY/ABSTRACT The overall goal of this proposed research is to develop a biomarker that prognosticates and correlates with the clinical expression of pain in sickle cell disease (SCD). Severe, debilitating pain is the most common complication of SCD, an inherited hemoglobinopathy affectin…
Ross C. Larue · OHIO STATE UNIVERSITY · 2024 · $236,250 — HISTONE MODIFICATIONS GUIDING HIV INTEGRATION PROJECT SUMMARY / ABSTRACT Human immunodeficiency virus (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS) with ~36.7 million people currently infected worldwide. Integration of the viral genome establishes an irreversible insert…
Michelle C Barbeau · UNIVERSITY OF VIRGINIA · 2024 · $40,415 — PROJECT SUMMARY The epithelial-mesenchymal transition (EMT) is a developmental process that is aberrantly reactivated in pancreatic ductal adenocarcinoma (PDAC) to promote disease progression and chemoresistance. PDAC tumors and cell lines typically contain a heterogeneous mixture of transformed cel…
Lorraine Brenda Robbins · MICHIGAN STATE UNIVERSITY · 2024 · $691,434 — Abstract Inadequate physical activity and poor diet quality contribute to the high overweight/obesity (OW/O) prevalence in adolescents, aged 12-19 years, indicating a need to intervene at or before age 12. Compared with other adolescents, underserved (minority; low socioeconomic status) adolescents …
William R. Ledoux · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · 2024 · $263,768 — PROJECT SUMMARY/ABSTRACT The first metatarsophalangeal joint (MTPJ1) is one of the sites most often affected by osteoarthritis, leading to a condition called hallux rigidus (HR). This is very common, estimated to affect 25% of the adult population and increasing in prevalence with age. The number of…
CHANDRA MOHAN · UNIVERSITY OF HOUSTON · 2024 · $174,892 — Anti-nuclear antibodies (ANA) are used as one of the diagnostic criteria for SLE, but they display poor diagnostic specificity for SLE (~76%), as they are also detected in 20-40% of healthy individuals and are frequently observed in other autoimmune diseases. Anti-DNA and anti-nucleosome antibodies …
Adam L MacLean · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $412,500 — Project Summary The goal of this research program is to provide tools for the discovery of transcriptional networks that control cell fate decisions. Cell fate decisions driven by cell state transitions underlie essential cell processes from development to cellular reprogramming. There is an opportu…
Seongmin Lee · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $343,610 — ABSTRACT Alkylation DNA damage caused by alkylating agents promotes mutations and cancer development. Guanine N7 is targeted by a wide range of alkylating mutagens, carcinogens, and anticancer agents, producing the cationic N7-alkylguanine (N7-alkylG) adducts as major lesions. These lesions have hal…
JEFFREY G JARVIK · UNIVERSITY OF WASHINGTON · 2024 · $782,516 — The overall aim of our CCCR is to develop and provide scientifically rigorous, state-of-the-art methods and resources for conducting musculoskeletal clinical research, thereby expanding the community of investigators performing high-quality musculoskeletal clinical research and increasing the amount…
Gary Fanger · RISE THERAPEUTICS, LLC · 2024 · $995,869 — Project Summary Type 1 diabetes (T1D) is a devastating disease and there is no current curative treatment, with insulin being the only product available. T1D affects not only glycemic control but also many important aspects of a patient's life, including emotional well-being, quality of life, workin…
Zihai Li · OHIO STATE UNIVERSITY · 2024 · $521,454 — PROJECT SUMMARY As a ubiquitous HSP90 paralog in the endoplasmic reticulum (ER), GRP94 plays important roles in protein quality control in the secretory pathway by participating in both the unfolded protein response and the ER-associated protein degradation pathway. My laboratory has demonstrated th…