NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Valentina Perosa · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $123,714 — Project Summary/Abstract Title: Understanding the mechanistic link between vascular dysfunction and Alzheimer’s disease-related protein accumulation in the medial temporal lobe. Cerebral small vessel disease (CSVD), which affects small vessels of the brain in the form of cerebral amyloid angiopathy …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Brett Stewart Carver · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $383,552 — PROJECT SUMMARY/ABSTRACT Since its inception in 1999, the primary objective of the T32 Urologic Oncology Research Training Program at Memorial Sloan Kettering Cancer Center (MSK) has been to train select urologists for productive careers in translational research in urologic oncology. Dedicated rese…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Beth A Costine-Bartell · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $335,881 — PROJECT SUMMARY The pathophysiology of hemispheric hypodensity is unknown. It is a pattern of brain damage only occurring in young children, often resulting from abuse, where the majority of the hemisphere underlying the subdural hematoma appears hypodense on computed tomography spanning multiple va…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Gavin S Schlissel · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · 2024 · $125,000 — Principal Investigator: Schlissel, Gavin Project summary Animal development and physiology require regular communication among cell types embedded in tissues. Cellular communication commonly relies on signaling proteins, which can transit the space between cells and relay information across a wide r…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Alan J Mouton · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $584,122 — PROJECT SUMMARY/ABSTRACT Approximately 1 million people in the United States suffer a myocardial infarction (MI) each year, leading to progressive cardiac dysfunction and development of heart failure (HF) in ~25% of surviving patients. Diabetes mellitus is a major risk factor for MI, and patients wi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MIGUEL A VAZQUEZ · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $1,238,148 — SPRINT, and its accompanying cognitive-focused substudy SPRINT-MIND recently showed that blood pressure control (goal SBP<120 mm Hg) reduced incident mild cognitive impairment as well as a combined outcome of MCI and dementia. Divergence in opinion among experts and professional societies about BP g…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Daisy Sahoo · MEDICAL COLLEGE OF WISCONSIN · 2024 · $15,000 — ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality world-wide. Development of new therapeutic approaches to combat CVD requires fundamental research and innovation, the results of which can be translated to improvement of human health. The Gordon Research Conf…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Aaron Cravens · REVEL PHARMACEUTICALS INC. · 2024 · $324,015 — PROJECT SUMMARY Diabetic kidney disease (DKD) is a major complication associated with Type 1 and Type 2 diabetes. Approximately 25% of patients with diabetes develop DKD. DKD is the leading cause of kidney failure and accounts for 44% of all end-stage renal disease cases. It is associated with heart…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
GREGORY A CLINES · VETERANS HEALTH ADMINISTRATION · 2024 — Prostate cancer is the most common deadly cancer of men. Bone metastasis is a painful complication of advanced prostate cancer associated with significant morbidity. Endothelin-1 (ET-1) is a prostate cancer- secreted factor that activates the osteoblast endothelin A receptor (ETAR) causing osteoblas…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Katelyn Guastaferro · NEW YORK UNIVERSITY · 2024 · $603,181 — ABSTRACT Child sexual abuse (CSA) is a global public health problem affecting 1 in 5 girls and 1 in 12 boys before age 18. Parents are uniquely positioned to protect children from CSA, yet parents have largely been ignored in CSA primary prevention efforts and the few that do exist have not demonstr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DAVID W SCHMIDTKE · UNIVERSITY OF TEXAS DALLAS · 2024 · $40,290 — Abstract Corneal scarring is a leading cause of blindness worldwide. Through their interactions with the extracellular matrix (ECM), stromal keratocytes play a central role in fundamental biological processes such as developmental morphogenesis and wound healing. Recent studies suggest that feedback…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Elizabeth A. Evans · TUFTS MEDICAL CENTER · 2024 · $392,637 — PROJECT SUMMARY A major driver of the U.S. HIV epidemic is inadequate access to HIV prevention and care in the criminal legal system. The End HIV Epidemic (EHE) Toolkit recommends that jails offer low-barrier access to HIV testing, treatment, and prevention to people who inject opioids, but many jus…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mohammed R Milad · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $678,226 — Project Summary Primary characteristics of posttraumatic stress disorder (PTSD) include persistent fears and excessive maladaptive avoidance behaviors. Preclinical models of PTSD have heavily investigated the brain mechanisms of fear inhibition and active avoidance learning. Significant progress has…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOSEPH Y LO · DUKE UNIVERSITY · 2024 · $552,589 — PROJECT SUMMARY / ABSTRACT Computed tomography (CT) imaging for the body can result in thousands of images spanning many organs and myriad possible diseases. With growing patient load as well as increasing resolution and complexity of scans, the task of CT interpretation has become daunting. To impr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHARNITA M. ZEIGLER-JOHNSON · RESEARCH INST OF FOX CHASE CAN CTR · 2024 · $507,193 — ABSTRACT Prostate cancer (PCa) is one of a few cancers with more than double the mortality for black men, making this one of the greatest racial disparities in cancer. Although there are documented disparities in PCa incidence and mortality related to where people live, it is unclear how residential…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Eugene Yu · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $450,011 — ABSTRACT The presence of an extra copy of human chromosome 21 (trisomy 21) is associated with Down syndrome (DS), and this is the most common live-born chromosomal alteration in humans. In the United States, DS has an incidence rate of approximately 1 in 691 newborns, and individuals with DS exhibit…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ANNE KATHRYN CHURCHLAND · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $393,750 — Abstract The main goal of my laboratory is to understand the neural circuits that support perceptual decision-making. Recent efforts to understand microcircuits within decision-making areas have been fruitful, thanks in part to the ability to identify and manipulate distinct types of inhibitory neur…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nabila El-Bassel · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2024 · $1,105,729 — Project Summary HIV prevalence in correctional facilities in the US is about five times greater than in the general population and about 14% of people living with HIV (PLWH) experience incarceration/release every year and 15% of those incarcerated do not know their HIV status. Over 50,000 people are…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Alfredo Andres Celedon · SCANOGEN, INC. · 2024 · $999,900 — Highly Multiplexed Single Molecule Tethering Summary Bloodstream infections in patients with sepsis symptoms should be promptly treated with antibiotics; however, the time required to identify pathogens using methods based on blood culture is a major obstacle to timely effective antimicrobial therap…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kimberly Michelle Hook · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $187,940 — PROJECT SUMMARY From 2010-2020, Eastern Europe reported a 72% increase in new adult HIV infections, representing the highest rate of increase globally. Among the Eastern European countries, the HIV epidemic in Ukraine is one of the largest, with nearly 260,000 people with HIV (PWH). Nevertheless, in…