Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
TALAT Alp IKIZLER · VETERANS HEALTH ADMINISTRATION · 2024 — There are more than 420,000 patients receiving maintenance hemodialysis therapy in the United States, which is estimated to rise to over 500,000 patients by 2020. There are an estimated 45,500 veterans receiving hemodialysis, of which over 3,000 enrolled veterans were receiving dialysis at VA facili…
Manhattan E Charurat · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $699,789 — PROJECT ABSTRACT Tobacco use is highly prevalent among people living with HIV/AIDS (PLWH) especially in southern Africa where HIV is most heavily concentrated. Among PLWH, tobacco use impacts HIV-related co-morbidities and is the leading cause of premature mortality from non-HIV related malignancies…
Bastiaan Driehuys · DUKE UNIVERSITY · 2024 · $736,853 — ABSTRACT The diagnosis and follow-up of patients with pulmonary arterial hypertension (PAH) continues to be challenging, with a lack of unambiguous biomarkers that reflect the course of the disease. PAH is characterized by pulmonary vascular remodeling with abnormal cellular proliferation and fibros…
JARED M. RADBEL · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $222,505 — Project Summary/Abstract Acute respiratory distress syndrome (ARDS) develops in some individuals as a sequela to indirect stress on the lung from systemic infection (sepsis/endotoxemia). However, it is unclear why only some patients with sepsis develop ARDS. One possible risk factor leading to ARDS…
Alexander Huang · UNIVERSITY OF PENNSYLVANIA · 2024 · $536,024 — Project Summary Anti-PD-1 therapy reinvigorates exhausted CD8 T cells, which can lead to complete tumor eradication as early as 3 weeks. Yet, despite robust T cell reinvigoration in >78% of patients, less than 40% are cured. The goal of this proposal is to understand why robust reinvigoration of exh…
Corinne E. Joshu · JOHNS HOPKINS UNIVERSITY · 2024 · $491,614 — This application is for a 5-year renewal (Years 39-43) of the Training Program in Cancer Epidemiology, Prevention, and Control (T32 CA009314) at the Johns Hopkins Bloomberg School of Public Health. Our mission is to train pre- and postdoctoral trainees to be leaders at the forefront of advancing kno…
Subo Yuan · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $400,000 — PROJECT SUMMARY Sensory neuropathy (SN) is the most common comorbidity in Human Immunodeficiency Virus-1(HIV-1) infected-patients (hHIV-SN), which affects 60% of the 37.9 million HIV infected patients in this world. hHIV-SN is particularly resistant to existing pain relief therapies and now there is…
Sriram Vaidyanathan · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $249,000 — Project Summary Cystic fibrosis (CF) is caused by mutations in a single gene called the cystic fibrosis transmembrane conductance regulator (CFTR), which codes for an ion channel that transports Cl- ions. CF affects many organs but lung failure caused by repeated respiratory infections is the leadin…
THANH H NEVILLE · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $487,315 — Project Summary Compassionate end-of-life (EOL) care is foundational to medicine, but providing patients and families in safety-net hospitals (SNHs) with the sense that they are physically and emotionally supported during a patient’s terminal hospitalization can be challenging. SNHs are public hosp…
Yaguang Xi · UNIVERSITY OF GEORGIA · 2024 · $533,414 — Project Summary: The overall survival of colorectal cancer (CRC) patients has improved significantly over the past few decades, but the 5-year survival rate for patients with stage IV CRC remains below 14%. Therefore, there is an urgent need to develop more effective and safer treatments against CRC…
STELLAH GEORGE MPAGAMA · UNIVERSITY OF VIRGINIA · 2024 · $104,082 — SUMMARY / ABSTRACT Human immunodeficiency virus (HIV) remains a major cause of morbidity and mortality in Tanzania despite access to highly active antiretroviral therapy, and tuberculosis (TB) is the leading cause of death among people with HIV in Tanzania and worldwide. The Kibong’oto Infectious Di…
Nicolaas Ida Bohnen · VETERANS HEALTH ADMINISTRATION · 2024 — The management of dopamine resistant postural instability and gait difficulty (PIGD) features, such as freezing of gait (FoG), represents perhaps the most important unmet clinical need in Parkinson's disease (PD). Research into the role of the vestibular system in the etiology of FoG has largely bee…
OLGA VINOGRADOVA · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $368,411 — Abstract Immune cells protect us from disease by detecting and responding to foreign molecules. Understanding the molecular basis of this response is critical if we are to generate new therapies for treatment or prevention of diseases involving immune cells. The objective of our research is to chara…
Brianne Olivieri-Mui · NORTHEASTERN UNIVERSITY · 2024 · $123,254 — Project Summary Antiretroviral therapy (ART) adherence among nursing home (NH) residents with HIV is less than optimal; in the literature 21% of people with HIV had no ART from their NH, which is in contrast to the 87.5% adherence among community dwelling older people with HIV. ART maintains viral s…
Jennifer E Totonchy · CHAPMAN UNIVERSITY · 2024 · $104,855 — Abstract/Project Summary Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic human herpesvirus, which causes Kaposi sarcoma (KS) as well as B cell lymphoproliferative disorders in the absence of adequate immune control. KSHV- associated tumors are a significant cause of morbidity and mortal…
Emily Wiecek · BOSTON CHILDREN'S HOSPITAL · 2024 · $142,669 — Two primary features of visual coding—spatial frequency and contrast perception—are abnormal in neurophysiological and behavioral measures of amblyopia. Mounting evidence indicates that interocular inhibition may drive amblyopic deficits, and this has led to the employment of varying gain control mo…
Ethel Cesarman · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $354,055 — The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologi…
Rebecca Robbins · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $141,750 — ABSTRACT In this K01 application, I will design and conduct a pilot study of a novel behavioral intervention to improve obstructive sleep apnea (OSA) evaluation and treatment among transportation workers. I will also explore whether improved adherence to recommended OSA evaluation and treatment is m…
Ansgar J. Furst · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · 2024 — Gulf War Veterans’ Illness (GWVI) is characterized by multiple chronic symptoms including wide-spread pain and sleep disturbances. This project will focus on brainstem structures and white matter pathways that specifically link the hypothalamus, periaqueductal gray and locus coeruleus (along the hyp…
TONY G BABB · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $482,805 — PROJECT SUMMARY/ABSTRACT Seventy% of older adults (60+ yr) are overweight or obese and many are unable or unwilling to exercise due to exercise intolerance and/or dyspnea on exertion (DOE). We have identified numerous obesity- related effects that could influence exercise tolerance and DOE in obese …