Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
KEVIN L. GARDNER · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $569,880 — Around the world, women of African ancestry and throughout the African Diaspora, continue to perish from breast cancer at significantly higher rates than any other racial/ethnic group. Although much of these disparate outcomes have been attributed to inequities in access to healthcare, socioeconomic…
MELISSA A HARRINGTON · DELAWARE STATE UNIVERSITY · 2024 · $1,142,020 — Overall Proposal Summary The Delaware Center for Neuroscience Research, established in 2012 with a COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD). Our unique Center brings together faculty and research resources from two very different in…
Kotaro Nakanishi · OHIO STATE UNIVERSITY · 2024 · $316,592 — PROJECT SUMMARY In eukaryotic cells, gene expression is regulated at multiple levels, including post-transcriptional gene silencing, where microRNAs (miRNAs) bind to complementary target RNAs and cause translational repression. Argonaute (AGO) proteins and miRNAs form RNA-induced silencing complexes…
Flemming Forsberg · THOMAS JEFFERSON UNIVERSITY · 2024 · $562,920 — Prostate cancer (PCa) is the most frequently diagnosed cancer among American males, accounting for 20% of new cancer diagnoses, but PCa is directly responsible for only 9% of cancer related deaths. PSA screening facilitates the detection of PCa, but many of the cancers detected by PSA screening are …
Momoko Yoshimoto · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · 2024 · $191,364 — Abstract IgA is the most abundant immunoglobulin produced in the lamina propria (LP) of the intestine and protects the host against microbial invasions into intestinal mucosa by coating and excluding them. Selective IgA deficiency is the most common immunodeficiency, and more than 50% of patients ar…
Joseph J. Fins · HARVARD MEDICAL SCHOOL · 2024 · $445,147 — Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI), …
Bridget Matikainen-Ankney · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $151,492 — Project Summary/Abstract. Despite the prevalence of obesity in the United States, how obesity strengthens brain circuits that reinforce feeding is not known. This K01 proposal will identify specific neural circuits and subcircuit mechanisms that enhance feeding and are co-opted in obesity. While pri…
Shiva Abbaszadeh · UNIVERSITY OF ARIZONA · 2024 · $407,636 — SUMMARY We are proposing a new approach to a hybrid imaging modality that has been called “b+g” or “pamma-positron” Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two different…
Nosheen Reza · UNIVERSITY OF PENNSYLVANIA · 2024 · $172,832 — PROJECT SUMMARY Hypertrophic cardiomyopathy is the most common inherited cardiac muscle disease with an estimated 750,000 affected individuals in the United States. However, only about 100,000 people have been diagnosed, suggesting that there are significant diagnostic and treatment gaps for individ…
Nicole Collins · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $41,362 — Project Summary/Abstract The energy utilized by the heart for contractions is primarily made by aerobic respiration. This process consists of oxidizing carbon substrates to fuel ATP synthesis. An essential substrate is oxygen which acts as the final electron acceptor. Without oxygen, ATP is rapidly …
Isabella Reichardt · UNIVERSITY OF WASHINGTON · 2024 · $43,841 — Project Summary Dilated cardiomyopathy (DCM) is a highly prevalent inherited cardiac disease, characterized by systolic dysfunction, eccentric hypertrophy, and left ventricle dilation. While pharmacologic and mechanical treatments have been shown to partially improve cardiac function, these results …
Abhijit A Date · UNIVERSITY OF ARIZONA · 2024 · $206,452 — PROJECT SUMMARY Tenofovir prodrugs, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide fumarate (TAF) are cornerstones of the first-line therapy in HIV/AIDS patients and there are at least 15 FDA-approved antiretroviral products that contain either TDF or TAF. However, due to their hydro…
Lukas Chavez · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2024 · $617,669 — The overall objective of this proposal is to investigate circular extrachromosomal DNA (ecDNA) as a potential driver of intratumoral heterogeneity and treatment resistance in medulloblastoma, the most common pediatric malignant brain tumor. Intratumoral heterogeneity is one of the leading determinan…
Dong Feng Chen · SCHEPENS EYE RESEARCH INSTITUTE · 2024 · $717,827 — Innate and Adaptive Immune Responses in the Pathogenesis of Glaucoma Glaucoma is a globally unmet medical challenge and a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is a major risk factor of glaucoma; yet, clinically it is neither required nor sufficient to cause ne…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $748,081 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
KATHERINE D MCREYNOLDS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · 2022 · $106,500 — PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic has resulted in millions of infections and over 2 million deaths worldwide since SARS-CoV-2 emerged in Wuhan, China in December of 2019. This pandemic has revealed a significant treatment gap in the ability to minimize the morbidity and mortali…
MALINI RAGHAVAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $188,280 — CD8+ T cells recognize short peptide antigens in the context of major histocompatibility complex class I (MHC- I) proteins. Three sets of genes, the human leukocyte antigens (HLA) HLA-A, HLA-B and HLA-C encode the heavy chains of human MHC-I (HLA-I) proteins, which also contain a light chain (β2-mic…
JOHN S. LAZO · KEVIRX INC. · 2022 · $55,000 — The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SAR-CoV-2, like other coronaviruses, infects human airways and enters cells via its S (Spike) protein, which binds to the human angiotensin-converting enzyme 2 (ACE2) and is primed by the…
JAMES W LARRICK · LARIX BIOSCIENCE, LLC · 2022 · $275,766 — Pan-COVID Therapeutic Abstract Severe COVID-19 remains as an urgent unmet clinical need for unvaccinated people, particularly as the SARS- CoV-2 delta and omicron variants spread globally. Despite the rapid deployment of effective vaccines, a large percentage of Americans are not fully vaccinated. A…
Wei Li · MARSHALL UNIVERSITY · 2022 · $444,000 — Project Summary/Abstract Platelet activation and aggregation is a major component of thrombosis, an underlying cause of myocardial infarction, ischemic stroke, and severe COVID-19, a new viral respiratory illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Various antipla…