Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
M. CELESTE SIMON · UNIVERSITY OF PENNSYLVANIA · 2024 · $921,582 — Project Summary Renal cell carcinoma is among the ten most prevalent malignances in the United States, exhibiting an increased incidence in both men and women since 2001. The most common kidney cancer subtype is “clear cell” renal cell carcinoma (ccRCC), which accounts for ~75% of all cases. For ear…
Jonathan J Miner · UNIVERSITY OF PENNSYLVANIA · 2024 · $795,004 — Project Abstract The goal of this proposal is to define the mechanisms of retinal vasculopathy with cerebral leukoencephalopathy (RVCL), an adult-onset vascular dementia associated with brain atrophy, blindness, and premature death, usually within 5-10 years of disease onset. RVCL is an autosomal do…
Lisa Ann Lewis · PLANET BIOTECHNOLOGY, INC. · 2024 · $300,000 — ABSTRACT Gonorrhea affects over 87 million people annually globally. In 2021, over 700,000 cases of gonorrhea were reported to the CDC, a 118% increase since the historic low in the US in 2009. However, the true incidence of cases annually in the US is estimated to be ~1.5 million. The spread of ant…
JONATHAN C HORTON · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $209,893 — Project Summary Approximately 2% of children in the United States have strabismus, a condition in which the eyes are not aligned properly. As a consequence, stereovision may be lost and the deviated eye is at risk for reduced vision from amblyopia. There are many other potential consequences, inclu…
Jessica Helene Hartman · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $354,458 — PROJECT SUMMARY Metabolism of alcohol (i.e., ethanol) to acetaldehyde within different brain regions and in different subcellular compartments, and how that metabolism changes with chronic ethanol use, is not well-understood. The long- term goal is to identify adaptive changes that occur in chronic …
JEFFREY S DOME · CHILDREN'S RESEARCH INSTITUTE · 2024 · $142,360 — Abstract Childhood cancer is the leading cause of disease-related death in children in the United States. The Children’s Oncology Group (COG), one of five clinical trials groups supported by the National Clinical Trials Network (NCTN), brings together more than 10,000 experts in childhood cancer rep…
Eric R Tkaczyk · VETERANS HEALTH ADMINISTRATION · 2024 — Chronic graft-versus-host disease (cGVHD) is the leading cause of nonrelapse mortality following allogeneic hematopoietic stem cell transplantation (HCT). Once the diagnosis is made, a fundamental practice gap remains the determination of whether disease is stable or progressing. Clinical trials of …
Angela R. Bradbury · UNIVERSITY OF PENNSYLVANIA · 2024 · $731,103 — Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. Yet, access to genetic specialists is limited in many areas in the US, and <20% of eligible patients with a personal or family history …
Arthur Seokjae Hong · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $555,561 — PROJECT SUMMARY/ABSTRACT Nearly all provider groups in Medicare’s five-year Oncology Care Model alternative payment program expressed a goal to reduce hospital use by cancer patients, but very few achieved this. Identifying potentially avoidable hospital care for cancer patients using diagnosis code…
Jennifer Gillette · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $410,264 — ABSTRACT / SUMMARY Responding to community concerns related to higher cancer incidences and worse outcomes among New Mexico’s ethnically and racially diverse communities, the University of New Mexico (UNM) Continuing Umbrella of Research Experiences (CURE) for Cancer program was inaugurated in 2015.…
Christopher Alan Haiman · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $634,844 — Abstract There is strong evidence that prostate cancer (PCa) is a heritable phenotype. In addition to greater risk observed in men with a family history of PCa, genome-wide association studies (GWAS) have identified over 400 common independent risk variants, which explain ~40% of the familial risk. …
Rong Chen · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $558,617 — Project Summary Current NIAAA strategic plan calls for efforts to identify novel molecular actions of alcohol and new remedies to mitigate alcohol-impacted brain regions. Ever-changing research tools have exponentially accelerated our understanding of brain regions and circuits affected by alcohol u…
Andrew James Barnes · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $2,307,901 — Project Summary Medicaid covers the majority of individuals who need opioid use disorder (OUD) treatment and disproportionately covers minoritized populations and those with socioeconomic risk factors. Improving OUD treatment quality in Medicaid thus can reach large numbers and inform efforts to red…
Juliane Gust · SEATTLE CHILDREN'S HOSPITAL · 2024 · $549,663 — PROJECT SUMMARY This project studies the mechanism of neurologic toxicity in chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically modified, patient derived T cells that use the CAR to recognize and destroy malignant target cells. Although CAR T therapy has shown impressive re…
Paula Catherine Chandler-Laney · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $1,584,627 — The Chronic Hypertension and Pregnancy (CHAP) randomized trial recently led to new national recommendations regarding antihypertensive treatment for chronic hypertension (CHTN) during pregnancy. CHAP tested treatment (vs. none) initiated before 23 weeks for mild CHTN (BP <160/105 mmHg) at 61 US site…
Jared Hutar · PIRAEUS MEDICAL, INC. · 2024 · $982,021 — PROJECT SUMMARY/ABSTRACT This proposal will improve the care of patients suffering from Acute Ischemic stroke (AIS). Catheter-based thrombectomy has been established as the standard treatment for AIS. Still, substantial limitations remain: <50% of patients achieve first-pass clot clearance, the best…
CHRISTOPH PROSCHEL · UNIVERSITY OF ROCHESTER · 2024 · $627,436 — PROJECT SUMMARY The Integrator Complex (INT) is a 17-subunit machinery that associates with RNA polymerase II (RNAPII) and functions as a critical transcription regulator. It is essential for the 3'-end formation of a variety of non-coding RNAs and is a broad negative regulator of promoter-proximal…
Chanita A. Hughes-Halbert · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $820,069 — SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer he…
Jennifer Kristin Wagner · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $240,600 — PROJECT SUMMARY Efforts to transform medicine from a reactionary, trial-and-error endeavor to an anticipatory, evidence- based endeavor referred to as “precision medicine” have been underway for several years. Concurrently, efforts also were undertaken to promote patient-centered “learning healthca…
Danielle Smith Bassett · UNIVERSITY OF PENNSYLVANIA · 2024 · $791,421 — PROJECT SUMMARY Association cortex undergoes protracted development throughout childhood and adolescence. This extended window of association cortex plasticity is understood to enhance executive and socioemotional functioning, whereas experiences that diminish plasticity—such as environmental adver…