NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ana M Abrantes · BUTLER HOSPITAL (PROVIDENCE, RI) · 2024 · $648,909 — Abstract Cannabis is the most widely used drug among pregnant women, and rates of use are increasing dramatically. Reasons for the sharp increase in cannabis use (CU) among in perinatal women are not clear. Changes in cannabis legalization, increased access and acceptability of the drug, and a perc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anne O'Donnell-Luria · BROAD INSTITUTE, INC. · 2024 · $651,581 — People in the United States (US) who are of African ancestry face medical genetic health disparities. They are less likely to receive accurate genetic diagnoses and face longer diagnostic odysseys, particularly for neurodevelopmental disorders such as Rubinstein-Taybi syndrome and epileptic encephal…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Byoung Chol Oh · EXPANSE BIO LLC · 2024 · $897,968 — ABSTRACT The kidney transplant waitlist comprises 83% of the U.S. organ transplant waitlist. Yet, for every 5 patients who die or become too sick for transplantation, 3 kidneys are discarded. Organ preservation quality is linked to graft lifespan with kidneys having only 50% graft survival after 10 …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Judith A VARNER · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $509,078 — Lung cancer is one of the most lethal of solid tumors. The overall survival rate for patients with lung cancer remains low, at 21%. As 236,740 new cases of lung cancer and 130,180 deaths are expected in 2022, there remains a pressing need to advance research into new therapeutic approaches for the t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Zhenyu Zhong · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $410,000 — Project Summary A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, whereas its imbalance results in genome instability that precipitates cellular damage and breach of homeostasis. Re…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Arvind Murugan · UNIVERSITY OF CHICAGO · 2024 · $384,390 — Project summary/abstract The success of life on earth derives from its use of molecules to carry information and implement algorithms that control chemistry, allowing organisms to respond adaptively to their environment. The ability to transduce information and respond adaptively ultimately relies o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MARK J SCHNITZER · STANFORD UNIVERSITY · 2024 · $789,034 — Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures. The dividends from this research will include sophisticated tools allowing selective genetic access to these cell-types, such as for imaging, optogenetic or tracing studi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOHN P MOORE · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $3,689,011 — Overall Abstract This HIVRAD Program Project renewal application is made in response to PAR-18-319. It contains two Research Projects, one Scientific Core and an Administrative Core, under the direction of Principal Investigator, John P. Moore, PhD (Weill Cornell Medical College; WCMC) and co-Princi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
HEINRICH GOTTLINGER · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $736,427 — PROJECT SUMMARY ADAM10 is a membrane-anchored endopeptidase that cleaves a range of membrane proteins at membrane- proximal external sites, and thus causes the shedding of their ectodomains. We now find that HIV-1 virions selectively incorporate considerable amounts of the active form of ADAM10. Our…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2021 · $22,016 — During the pandemic, Dr Ho has evaluated the challenges for developing antibody therapeutics targeting SARS-Cov-2 and wrote a review/perspective article [Ho Antibody Therapeutics 2020; PMID: 32566896]. SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-convert…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kyung Lee · DIVISION OF BASIC SCIENCES - NCI · 2021 · $224,347 — Our unbiased proteomic mass spectrometry and subsequent biochemical analyses showed that Plk4 binds to the C-terminal acidic domain (1401-1507) of a cellular scaffold protein, VprBP, via its C-terminal cryptic polo-box. Strikingly, HIV-1 Vpr, which binds to the WD40 domain (1003-1400) of VprBP, grea…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2021 · $638,442 — While antibody-based therapeutics have emerged as a major component in cancer treatment, the generation of antibodies to important targets such as cell surface receptors and ion channels remains difficult. These proteins contain buried functional sites that are often unreachable by classical mouse o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Bernard R Brooks · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $349,588 — Traditional molecular modeling is performed at atomic resolution, which relies on X-ray and NMR experiments to provide structural information. When dealing with biomolecular assemblies of millions of atoms, atomic description of molecular objects becomes very computational inefficient. We develope…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
NEAL DAVID EPSTEIN · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $603,253 — Endosymbionts are unicellular organisms that reside inside the cells of a host organism and can have dramatic influence over the host, ranging from nutritional provisioning to immune function and in the case of filarial nematodes, their actual development. It is estimated that more than 75% of inse…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Mark Connors · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $260,724 — Our laboratory is engaged in the study of the immune response to SARS-CoV-2 in two major areas. The first of these is the study of the immune response to natural infection. The second is the response to virus-like particles or replicating recombinant adenovirus type 4 (Ad4) vaccines. We are colla…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $476,501 — Over the past fiscal year, we have performed studies on four viral pathogens causing respiratory disease in humans, Nipah virus, influenza A virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Sin nombre hantavirus. Work on Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2)…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Lars Pedersen · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,804,628 — Our lab works on a variety of different biological systems including heparan/chondroitin sulfate biosynthesis as part of our independent work, representing about 25% of our effort and in other fields including DNA replication/repair, antibody/antigen interactions and viral infection in support of ot…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $593,205 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. In humans, the most common type of prion disease is Creut…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Matthew Hall · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $1,912,140 — During this past reporting period, NCATS began development of over a dozen novel assays to screen for potential therapeutic agents against SARS-CoV-2. Optimized assays were then screened against a panel of drug repurposing, clinical candidate and antiviral libraries that have been assembled at NCAT…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $170,000 — The emergence of the Wuhan new coronavirus (nCoV) initiated efforts to rapidly develop effective medical countermeasures including vaccines and therapeutics against this severe disease. However, there is limited knowledge on polyclonal antibody responses generated following vaccination or nCoV infec…