Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
ELIZABETH SHARLOW · UNIVERSITY OF VIRGINIA · 2020 · $161,500 — Project Summary We have established a human iPS-derived neuronal-glial cell model system that we are using to (1) study AβO-induced neuronal cell cycle reentry (CCR) as well as (2) screen for compounds that inhibit AβO-induced neuronal CCR. We now propose to adapt this cell-based model system to eva…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $766,414 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
SACHIN A GUPTE · NEW YORK MEDICAL COLLEGE · 2020 · $547,406 — Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in glucose metabolism and is also a master regulator of cellular redox signaling that plays a crucial role in the regulation of vascular function. We recently isolated and characterized long (G6PD545) and short (G6PD515) G6PD isoforms in vascu…
GARY Andrew WEISMAN · UNIVERSITY OF MISSOURI-COLUMBIA · 2020 · $232,102 — Salivary gland dysfunction is symptomatic of Sjögren’s syndrome (SS), an autoimmune disease associated with lymphocytic infiltration of the salivary gland. A commonality between many human autoimmune diseases, including SS, is chronic inflammation whereby sustained accumulation of immune cells promo…
Jeffrey C. Nolz · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $37,607 — ABSTRACT The current COVID-19 pandemic is a global health emergency, causing severe respiratory disease requiring hospitalization and even death in a significant proportion of the human population. Although therapeutic intervention including novel pharmaceuticals or the passive transfer of immune se…
Anil K Rustgi · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $162,000 — The SARS-CoV-2 pandemic has led to massive morbidity and mortality worldwide due to COVID-19, with the United States particularly affected. Risk factors for COVID-19 include male sex, older age, and obesity, amongst others, which are also key risk factors for Barrett’s esophagus (BE) and esophageal …
BRIAN KENNETH KAY · TANGO BIOSCIENCES, INC. · 2020 · $183,318 — Project Summary Funds are requested to apply technologies being developed in a current NIGMS award to generate recombinant antibody-like affinity reagents to the spike protein of the SARS-CoV-2 virus. As a proof-of-principle experiment, we have already isolated four fibronectin type III (FN3) monobo…
SCOTT M. RAWLS · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $158,500 — Human death in persons infected with SARS-CoV-2 (the virus responsible for the covid-19 pandemic) is caused by barriers dysfunction (i.e. in the pulmonary system). Angiotensin- converting enzyme 2 (ACE2) has been identified as a functional receptor of SARS-CoV-2, similarly to other coronaviruses. Su…
Michael-Christopher Keogh · EPICYPHER, INC. · 2020 · $978,257 — PROJECT SUMMARY Alterations in chromatin regulators are associated with diverse human pathologies. The ability to quantitatively assess these factors in healthy and diseased cells is essential to accelerate the development of therapeutics targeting epigenetic regulation (a growing area of study, wi…
BRUCE J SHENKER · UNIVERSITY OF PENNSYLVANIA · 2020 · $243,125 — We are requesting a one year administrative supplement to our RO1 grant DE006014 entitled Bacteria and lymphocyte suppression in periodontitis. The purpose of this request is to expand the scope of the grant to take advantage of recent observations made on the cytolethal distending toxin (Cdt) and a…
CHARLES S FUCHS · YALE UNIVERSITY · 2020 · $327,490 — A promising therapeutic and prophylactic strategy against COVID-19 is passive immunization through the transfer of anti-SARS-CoV-2 neutralizing antibodies and convalescent serum. However, there is growing evidence that antibody responses to the virus can also directly contribute to lethal immunopath…
DONALD E INGBER · HARVARD UNIVERSITY · 2020 · $928,351 — PROJECT SUMMARY This COMPETITIVE REVISION application is being submitted to expand the scope of our ongoing NIH grant UH3HL141797 in order to leverage our human organ-on-a-chip (Organ Chip) microfluidic culture devices for the rapid development and assessment of potential therapeutic agents for COV…
STEPHEN COPLAN HARRISON · BOSTON CHILDREN'S HOSPITAL · 2020 · $420,375 — Summary The structure of a virus particle must conform to the mechanism by which it enters and infects a cell. We seek to relate structures of virus particles and viral surface proteins to mechanisms of the steps in cell attachment, uptake and penetration that initiate a productive infection. The pr…
Bidadi Venkataram Prasad · BAYLOR COLLEGE OF MEDICINE · 2020 · $665,150 — The long-term goal of our research is to understand the structural basis of the complex processes that regulate the replication cycle of rotaviruses (RVs), which are the global pathogens causing life-threatening infantile gastroenteritis. During 2013-2016, our studies have answered several questions…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2020 · $2,711,483 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Rebecca Michelle DuBois · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2020 · $350,421 — PROJECT SUMMARY Human astroviruses (HAstV) are a leading cause of viral diarrhea in children. Divergent HAstV strains are associated with fatal human encephalitis. Currently, no vaccines or antiviral therapies exist for HAstV infections. Our goal is to identify sites of vulnerability (Achilles' heel…
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2020 · $313,503 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
Lanying Du · NEW YORK BLOOD CENTER · 2020 · $816,658 — Abstract Traditional strategies of vaccine development suffer from long-term and costly manufacture, and as a result, often fail to respond rapidly to newly emerging and reemerging infectious diseases. By contrast, messenger RNA (mRNA) is rising as a new technology platform to develop vaccines “on d…
JANICE P EVANS · PURDUE UNIVERSITY · 2020 · $77,500 — PROJECT SUMMARY Actin cytoskeleton-based processes play crucial roles in meiosis in mammalian oocytes, including positioning of the meiotic spindle and asymmetric cell division. These events in oocytes are essential for reproductive success, as gene knockouts that impair these processes cause femal…
Tal Somekh · ERISYON INC · 2020 · $247,876 — ABSTRACT Parkinson’s disease (PD) is a neurodegenerative disorder that is typically diagnosed when 60% of a brain region’s dopaminergic neurons have already degenerated. A strong contender for the elusive molecular biomarker is a neuronal protein - α-synuclein and its post-translationally modified p…