Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
AJAY NMN RANA · JESSE BROWN VA MEDICAL CENTER · 2021 — Project Summary/Abstract: The main focus of research in our group is to understand the underlying molecular mechanisms of pancreatic and breast cancer pathogenesis. The overarching goal of our research is to investigate how the cellular pathways (i.e. circuits) are dysregulated and can lead to uncon…
Haifa Shen · METHODIST HOSPITAL RESEARCH INSTITUTE · 2021 · $463,570 — The tumor vasculature is generally considered as leaky, and thus allows accumulation of big molecules and particles within a certain size range to penetrate and retain. Consequently, many cancer drugs have been packaged into simple nanoparticles or composite drug particles in order to improve accumu…
Kerry S Campbell · THOMAS JEFFERSON UNIVERSITY · 2021 · $510,193 — Project Summary NK cells are capable of killing virus-infected and cancer cells and, therefore, play an important role in innate host defense. Unlike cytotoxic T lymphocytes (CTL), whose cytolytic activity is induced by productive TCR engagement with cognate pMHC ligands, activation of NK cells is r…
Song Li · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $428,652 — The amplification of Estrogen, Progesterone and Human Epidermal Growth Factor receptors (i.e. ER, PR and HER2) serve as prognostic markers in breast cancer. The prognosis of ER+ breast cancer is relatively better due to availability of several drugs that essentially block ER-signaling. However, HER2…
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2021 · $197,807 — PROJECT SUMMARY This proposal aims to develop live-cell, multi-channel imaging tools that can visualize—continuously, and in real time—nanoparticle interactions with cellular components. We will focus on several different time windows, where early time periods will monitor nanoparticle-cell membran…
Kent Lai · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $228,750 — PROJECT SUMMARY / ABSTRACT Hereditary deficiency of galactose-1-phosphate uridylyltransferase (GALT, E.C. 2.7.7.12) activity in humans can lead to a potentially lethal disease called Classic Galactosemia (OMIM 230400). Despite the life-saving consequences of newborn screening, early diagnosis, and …
Weihua Qiu · VIRGINIA COMMONWEALTH UNIVERSITY · 2021 · $229,008 — SUMMARY Connexin 26, as a gap junction channel, directly regulates the cell-to-cell exchange of ion, metabolites, and second messengers. Mutations of connexin 26 can cause severe hearing loss. However, the molecular gating mechanism on the structural basis of connexin 26 is still unclear, especially…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2021 · $658,627 — ABSTRACT: Cystic fibrosis (CF) is conferred by any of ≥1200 known mutations in the gene encoding the CFTR, an ion transporter protein, but in principle, a single gene therapy agent that delivers expression of functional CFTR could treat. Prior attempts to do so have used adeno-associated viral or li…
JENNIFER A DOUDNA · UNIVERSITY OF CALIFORNIA BERKELEY · 2021 · $776,316 — PROJECT SUMMARY / ABSTRACT CRISPR-Cas9 has demonstrated incredible potential to provide clinical benefit, but the challenge of delivery currently hinders therapeutic use of genome editing in vivo. Use of viral vectors and lipid nanoparticles has established the viability of in vivo genome editing, b…
Gretchen Mahler · STATE UNIVERSITY OF NY,BINGHAMTON · 2021 · $303,320 — PROJECT SUMMARY Nanomaterials are increasingly used in consumer products, processed food, and food packaging, and few studies have determined the consequences of nanoparticle ingestion. The ultimate goal of this work is to determine if and how ingested metal oxide nanoparticles alter microorganism p…
Cynthia Arbeeny · MITOTHERAPEUTIX, LLC · 2021 · $253,050 — Abstract The goal of this SBIR fast-track application is to carry out a number of IND enabling studies on our siRNA drug candidate, which is designed to treat non-alcohol steatohepatitis (NASH). NASH is a form of non-alcohol fatty liver disease (NAFLD) and results from a pathological accumulation of…
Jayanth Panyam · TEMPLE UNIV OF THE COMMONWEALTH · 2021 · $374,075 — Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune response. However, currently available TLR agonists suffer from a number of limitations including self-regulatory immun…
MICHAEL Allan HOLINSTAT · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $146,455 — ABSTRACT Platelets play an essential role in the vessel, maintaining hemostasis and normal blood flow following vascular insult or injury under physiological conditions. While activation of the platelet is essential for adhesion and aggregation to occur at the site of vascular injury, excessive plat…
Gabor Csanyi · AUGUSTA UNIVERSITY · 2021 · $385,000 — Project Summary Atherosclerosis, the main underlying cause of death worldwide, is characterized by chronic inflammation and accumulation of lipids in the arterial wall. Excessive lipid accumulation by macrophages (MΦs) and vascular smooth muscle cells (SMCs) plays a key role in the initiation and pr…
Craig Lewis Duvall · VANDERBILT UNIVERSITY · 2021 · $170,194 — Project Summary / Abstract Osteoarthritis (OA) is a chronic degenerative disease that affects joints and their surrounding tissues. OA can occur spontaneously with aging or be secondary to injury in the case of post-traumatic osteoarthritis (PTOA). OA/PTOA causes significant morbidity and loss of qu…
Hana Totary-Jain · UNIVERSITY OF SOUTH FLORIDA · 2021 · $535,285 — Atherosclerotic cardiovascular disease (CVD) represents a serious affliction affecting millions globally. Despite recent advances in pharmacological and percutaneous interventions, CVD remains the leading cause of death and disability in the world. One of the main therapeutic challenges facing ather…
Michelle S Bradbury · SLOAN-KETTERING INST CAN RESEARCH · 2021 · $637,054 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Johannes Morstein · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $83,268 — Project Summary Significant progress in human cancer therapy in the last decade has been driven by conceptionally new approaches to targeting cancer, including cancer immunotherapy, cancer nanotherapy, or new types of biologics and small molecules. Both my dissertation and postdoc research will be f…
Aaron Clifford Brown · MAINEHEALTH · 2021 · $430,000 — Project Summary/Abstract The obesity epidemic is a global public health issue, that leads to an increased risk for type 2 diabetes and cardiovascular disease. Hypertrophy, inflammation, and excess lipid accumulation in white adipocytes within fat tissue are hallmarks of obesity that contribute to me…
WADIH ARAP · RBHS -CANCER INSTITUTE OF NEW JERSEY · 2021 · $642,358 — ABSTRACT Eight percent of patients diagnosed with prostate cancer progress to lethal metastatic disease. Development of resistance to androgen-deprivation therapy and eventually, to last line chemotherapeutics such as enzalutamide (ENZ), contribute to lethal, metastatic prostate cancer. While intere…