Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Zahi A. Fayad · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $815,005 — SUMMARY Atherosclerotic plaque regression as a result of lipid-lowering treatment has been limited at best, with coronary artery disease (CAD) related event rates remaining unacceptably high. In this application, we propose that targeted immunomodulation of macrophages will resolve plaque inflamma…
Amer Alam · UNIVERSITY OF MINNESOTA · 2021 · $435,750 — Project Summary Alzheimer’s disease (AD) represents one of the foremost healthcare challenges of our times and is a leading cause of death worldwide. AD accounts for the overwhelming majority of dementias, which affect over 35 million people worldwide. This number is expected to double every twenty …
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2021 · $711,044 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
Jae K Lee · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $481,767 — PROJECT SUMMARY/ABSTRACT After spinal cord injury (SCI), the injury site is filled with cellular debris, especially myelin debris that creates a very unique lipid-dense environment. Macrophages are the predominant phagocyte that are responsible for debris-clearance, but this process is not only inef…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $486,326 — Abstract Aberrant lipoprotein metabolism is a hallmark of obesity that affects >40% of Americans. Obesity and its com- plications, including type-2 diabetes (T2D), cardiovascular, amyloid and severe viral diseases, are the leading causes of premature death. The ultimate goal of this research is to …
Karen N. Allen · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $451,334 — Complex glycoconjugates play a pivotal role in bacterial survival, colonization and virulence and contribute to the interactions between symbiotic and pathogenic bacteria and their human hosts. An important mechanism for the assembly of these structures is initiated on the cytoplasmic face of cell m…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2021 · $733,169 — Summary. Hemoglobinopathies such as β-thalassemia and sickle cell disease are genetic disorders caused by mutations in the HBB gene that codes for the β-globin component of hemoglobin. Currently, the only gene therapy available for these prevalent hereditary diseases is based on transplantation of g…
John B Barnett · EXESALIBERO, INC. · 2021 · $394,939 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Jinjun Shi · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $711,340 — ABSTRACT With the ability to silence individual genes and to drug the ‘undruggable’, RNA interference (RNAi) therapy has recently shown clinical success by delivering small interfering RNA (siRNA) to the liver for genetic diseases. However, new delivery strategies will be needed to expand the target…
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2021 · $536,021 — PROJECT SUMMARY Liver transplantation is currently the only treatment for acute and chronic liver failure. Given the shortage of donor livers, hepatocyte transplantation is considered a potential treatment for liver diseases and a bridge for patients awaiting liver transplantation, but its applicati…
Esma Alp · KALOCYTE, INC. · 2021 · $499,999 — Project Summary/Abstract ErythroMer (EM) is a novel biosynthetic blood substitute developed to address the critically unmet need for emergency transfusion in situations where the use of banked red blood cells (RBCs) are inaccessible or undesirable. EM is a self-assembled lipid-peptidic hybrid nanopa…
Bruce Shapiro · DIVISION OF BASIC SCIENCES - NCI · 2021 · $871,639 — Recently we developed a new type of RNA nanostructure that forms a truncated tetrahedron in collaboration with Luc Jaeger, UC Santa Barbara. The structure was built from our hexameric ring where 4 sides of the tetrahedral structure each contain the hexmeric ring, but each ring contains 3 H-shaped cr…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2021 · $330,352 — The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestina…
Huan Xie · TEXAS SOUTHERN UNIVERSITY · 2021 · $224,138 — PROJECT SUMMARY Prostate cancer (PCa) is the second leading cause of cancer death in the United States among men and it is more common in African American males. Despite initial good responses to androgen deprivation or anti- androgen drugs, tumors invariably recur and develop into lethal castration…
Colby Shad Thaxton · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $398,137 — SUMMARY The overall goal of the Lipid-Based Self-Assembled Materials and Characterization Core (LBSAMCC) is to synthesize, characterize, and deliver highly novel therapeutics for ameliorating the devastating effects of nitrogen and sulfur mustards to the eye (Project 1) and skin (Project 2). High-de…
TIMOTHY M GRIFFIN · OKLAHOMA CITY VA MEDICAL CENTER · 2020 — Osteoarthritis (OA) disproportionately affects veterans, resulting in more pain and functional limitations compared to the general population. No disease-modifying treatments exist for OA, and current pain medications (e.g., opioids and NSAIDs) have limited long-term efficacy and adverse side effect…
John B Barnett · EXESALIBERO, INC. · 2020 · $108,153 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $182,288 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
Gabor Csanyi · AUGUSTA UNIVERSITY · 2020 · $384,687 — Project Summary Atherosclerosis, the main underlying cause of death worldwide, is characterized by chronic inflammation and accumulation of lipids in the arterial wall. Excessive lipid accumulation by macrophages (MΦs) and vascular smooth muscle cells (SMCs) plays a key role in the initiation and pr…
Zahi A. Fayad · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $815,612 — SUMMARY Atherosclerotic plaque regression as a result of lipid-lowering treatment has been limited at best, with coronary artery disease (CAD) related event rates remaining unacceptably high. In this application, we propose that targeted immunomodulation of macrophages will resolve plaque inflamma…