Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Gretchen Mahler · STATE UNIVERSITY OF NY,BINGHAMTON · 2020 · $303,663 — PROJECT SUMMARY Nanomaterials are increasingly used in consumer products, processed food, and food packaging, and few studies have determined the consequences of nanoparticle ingestion. The ultimate goal of this work is to determine if and how ingested metal oxide nanoparticles alter microorganism p…
Sashwati Roy · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $393,750 — ABSTRACT Persistent unresolved inflammation impairs diabetic wound healing. The function and fate of wound monocyte/macrophages (mϕ) hold the key to the outcome of wound inflammation. This proposal builds on observations originating from live functional wound macrophages (wmϕ) and wound fluid derive…
Kevin V Morris · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2020 · $440,000 — Project Summary Targeted transcriptional activation of HIV Human Immunodeficiency Virus type 1 (HIV-1) is a lentivirus that causes a persistent viral infection that results in the demise of immune regulatory cells. Clearance of HIV-1 infection by the immune system is inefficient, and integration of …
Rajagopal Ramesh · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2020 · $306,308 — Effective control of lung cancer continues to remain a clinical challenge resulting in poor five-year survival rate. Currently available therapies while showing promise have had limitations. Therefore, continued efforts for developing new therapeutic agents and systemic treatment modalities are warr…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2020 · $666,748 — ABSTRACT: Cystic fibrosis (CF) is conferred by any of ≥1200 known mutations in the gene encoding the CFTR, an ion transporter protein, but in principle, a single gene therapy agent that delivers expression of functional CFTR could treat. Prior attempts to do so have used adeno-associated viral or li…
Chad V Pecot · ENFUEGO THERAPEUTICS INC. · 2020 · $224,995 — Research Summary: The KRAS proto-oncogene is one of the most critical genes in cancer, yet it has also proven to be among the most elusive. Nearly all (98%) of KRAS missense mutations occur in codons 12 or 13, which leads to constitutive KRAS activation and promotion of numerous cancer hallmarks. Al…
James F. Collins · UNIVERSITY OF FLORIDA · 2020 · $511,395 — Project Summary Iron is an essential nutrient for humans, yet excess iron is toxic. As such, iron overload and iron deficiency result in severe homeostatic perturbations. Iron overload is most frequently associated with hereditary hemochromatosis (HH), which afflicts ~1:250 adults in the U.S. Tissue…
HUGO Ramon ROSEN · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $371,250 — PROJECT SUMMARY /ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, affecting at least a quarter of the world’s population, and therefore highly relevant to the NIH mission. From steatosis to fibrosis, hepatic inflammation drives disease progression…
Jinjun Shi · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $540,226 — DESCRIPTION (provided by applicant): Given the capability of modulating individual gene expression in tumor cells, RNA agents such as small interfering RNA (siRNA) and messenger RNA (mRNA) have demonstrated tremendous potential in revealing the functionality of specific gene alterations and ena…
Huang Chiao Huang · UNIV OF MARYLAND, COLLEGE PARK · 2020 · $202,977 — DESCRIPTION (provided by applicant): It is increasingly evident that rationally designed combination therapies impacting multiple targets will most likely to improve outcomes in patients with glioblastoma (GBM). However, the selective delivery of multiple regimens to the right place, at the right ti…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2020 · $285,821 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
AJAY NMN RANA · JESSE BROWN VA MEDICAL CENTER · 2020 — Project Summary/Abstract: The main focus of research in our group is to understand the underlying molecular mechanisms of pancreatic and breast cancer pathogenesis. The overarching goal of our research is to investigate how the cellular pathways (i.e. circuits) are dysregulated and can lead to uncon…
Sarah EV Richards · BROAD INSTITUTE, INC. · 2020 · $425,000 — Aging-related neurological diseases impact millions people worldwide, and this number is expected to increase drastically as the global average age continues to increase. While the need to develop new neuroprotective therapeutics has never been higher, our current efforts rely on only a partial unde…
Gregory J Dodge · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $65,310 — Abstract: This project aims to expand the mechanistic understanding of the initial membrane-associated steps of bacterial glycoconjugate biosynthesis. Membrane protein structures are critically underrepresented in the protein data bank (PDB), and remain difficult targets for purification, character…
JENNIFER A DOUDNA · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $781,190 — PROJECT SUMMARY / ABSTRACT CRISPR-Cas9 has demonstrated incredible potential to provide clinical benefit, but the challenge of delivery currently hinders therapeutic use of genome editing in vivo. Use of viral vectors and lipid nanoparticles has established the viability of in vivo genome editing, b…
Andrei Maiseyeu · CASE WESTERN RESERVE UNIVERSITY · 2020 · $396,250 — Project Summary Hyperglycemia is the hallmark of type 2 diabetes (T2D) and accelerates the development of atherosclerosis, which, in turn, precedes the development of major cardiovascular complications. In people with T2D, cardiovascular disease significantly contributes to mortality, accounting fo…
Daniel John Siegwart · UT SOUTHWESTERN MEDICAL CENTER · 2020 · $364,500 — Project Summary Co-delivery of Cas9 mRNA and targeted sgRNA is a promising strategy to achieve CRISPR/Cas gene editing in vivo with improved safety. Although great advances have been made in the delivery of short RNAs (siRNA, miRNA), the ideal chemical and formulation composition is largely unknown …
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2020 · $555,521 — PROJECT SUMMARY Liver transplantation is currently the only treatment for acute and chronic liver failure. Given the shortage of donor livers, hepatocyte transplantation is considered a potential treatment for liver diseases and a bridge for patients awaiting liver transplantation, but its applicati…
Ann Cornwall Collier · UNIVERSITY OF WASHINGTON · 2020 · $771,303 — The Targeted Long-acting Combination Antiretroviral Therapy (TLC-ART) Program has discovered a novel platform that can stabilize insoluble and soluble antiretroviral drugs together in a nanosuspension which provides long-acting (LA) plasma and cell concentrations in pre-clinical studies. The lead fo…
Juliane Nguyen · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $358,348 — PROJECT SUMMARY/ABSTRACT Exosomes were originally thought of as the cellular “waste-disposal system.” It is now known that they are important for intercellular communication and contribute to the pathogenesis of several diseases including cancer, neurodegenerative disease, and autoimmunity. Once sec…