Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Evan Alexander Scott · NORTHWESTERN UNIVERSITY · 2020 · $685,339 — PROJECT SUMMARY Subunit vaccines combine immunodominant protein or peptide antigens from pathogens with select adjuvants, aiming to provide a more scalable, reproducible, low cost and rapid alternative to attenuated vaccines that contain live pathogens. Unfortunately, current subunit vaccines lack …
Jin Xie · UNIVERSITY OF GEORGIA · 2020 · $471,199 — Abstract Photodynamic therapy (PDT) has gained much attention as a relatively new cancer treatment modality. PDT has a favorable toxicity profile compared to radiotherapy. Meanwhile, it does not incur resistance, and can be applied to previously irradiated tissues. However, the use of PDT in the cl…
Mary Jane Thomassen · EAST CAROLINA UNIVERSITY · 2020 · $311,261 — DESCRIPTION (provided by applicant): Pulmonary granuloma formation is a key feature of sarcoidosis, a chronic disease of unknown etiology. Sarcoidosis has been linked to environmental risk factors (wood-burning stoves, fireplaces and firefighting) that favor carbon nanotube formation. We have shown …
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $382,600 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
Martina Ralle · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $189,857 — Project Summary X-ray fluorescence microscopy (XFM) has emerged as powerful tool to visualize metals within cells or tissue. Using X-ray microprobes, investigators can now produce elemental maps of biological material at the cellular and subcellular levels. Determining the elemental distribution and…
GREGORY C GIBSON · GEORGIA INSTITUTE OF TECHNOLOGY · 2020 · $173,912 — Project Summary Over the past decade, the NIDDK IBDGC (Inflammatory Bowel Disease Genetics Consortium) has generated extraordinary datasets in support of genetic analysis of the onset, progression, and therapeutic response to Crohn's disease and ulcerative colitis. This Ancillary project will comple…
Michelle S Bradbury · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $658,454 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Song Hong · LSU HEALTH SCIENCES CENTER · 2020 · $381,265 — ABSTRACT We are applying for a 1-year supplemental award in response to NIH Notice NOT-AG-20-008 “AD/ADRD- focused supplements for NIH grants that are not focused on AD/ADRD.” The goal of the parent project of this supplement is to develop pro-resolving reparative maresin-like lipid mediators encaps…
Maria Lambros · DORICPHARMA LLC · 2020 · $102,195 — PROJECT SUMMARY/ABSTRACT Pancreatic cancer continues to be a devastating disease with less than 10% 5-year survival. Pancreatic cancer is aggressive and there are no good tools for early detection. By the time of diagnosis, the tumor is often surgically unresectable. At this stage, patients are ofte…
DARRICK Albert CARTER · PAI LIFE SCIENCES, INC. · 2020 · $556,615 — PROJECT SUMMARY A central mechanism of tumor drug resistance is the maintenance of tight junctions between malignant cells preventing penetration of molecules into the tumor microenvironment. We have generated junction openers (“JO”) that are small proteins that bind to desmoglein 2 (DSG2), a juncti…
Huan Xie · TEXAS SOUTHERN UNIVERSITY · 2020 · $226,261 — PROJECT SUMMARY Prostate cancer (PCa) is the second leading cause of cancer death in the United States among men and it is more common in African American males. Despite initial good responses to androgen deprivation or anti- androgen drugs, tumors invariably recur and develop into lethal castration…
JAY W HEINECKE · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $262,515 — We propose to investigate the structural basis of the interaction of LCAT with HDL. We will complement these in vitro studies with analyses of HDLs of subjects with LCAT deficiency. Because these patients have very low HDL-C levels but apparently little increased cardiovascular risk, their HDL might…
TIMOTHY J. WILKIN · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $1,017,165 — Clinical Trials Program Project Summary/Abstract The overall goal of the proposal is to advance prevention interventions for HPV-associated cancers occurring among men and women living with HIV in Latin America and the Caribbean (LAC). We are focusing on prevention of two HPV-associated cancers, or…
YONG ZHU · YALE UNIVERSITY · 2019 · $182,156 — Abstract The goal of the proposed study is to demonstrate the viability of a novel Piwi-interacting RNA (piRNA)-based therapeutic strategy for the treatment of hepatocellular carcinoma (HCC). piRNAs are an abundant class of small (26-31 nt) non-coding RNAs with approximately 23,000 known human membe…
Huang Chiao Huang · UNIV OF MARYLAND, COLLEGE PARK · 2019 · $249,000 — DESCRIPTION (provided by applicant): It is increasingly evident that rationally designed combination therapies impacting multiple targets will most likely to improve outcomes in patients with glioblastoma (GBM). However, the selective delivery of multiple regimens to the right place, at the right ti…
Andrei Maiseyeu · CASE WESTERN RESERVE UNIVERSITY · 2019 · $396,250 — Project Summary Hyperglycemia is the hallmark of type 2 diabetes (T2D) and accelerates the development of atherosclerosis, which, in turn, precedes the development of major cardiovascular complications. In people with T2D, cardiovascular disease significantly contributes to mortality, accounting fo…
Alexander Komin · JOHNS HOPKINS UNIVERSITY · 2019 · $35,908 — Project Summary The drug therapies against the central nervous system (CNS) disorders, such as brain cancer, stroke and Alzheimer's disease, are very limited because of the challenges associated with delivering drugs across the blood-brain barrier (BBB) into the brain. There is a need to develop nov…
Subhash C. Chauhan · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2019 · $140,790 — The long-term goal of the proposed research proposal is to develop a targeted paclitaxel nanotherapy that can be used for the treatment of pancreatic cancer (PanCa) in combination with Gemcitabine (GEM). Although many conventional and combinational chemotherapies exist to treat PanCa, significant si…
Ning Fang · GEORGIA STATE UNIVERSITY · 2019 · $301,325 — DESCRIPTION (provided by applicant): Viruses, drug delivery vectors, and other external particles exhibit a variety of complex behaviors on and in the cell membrane that are reflective of their physical and chemical properties, including size, shape, charge and the availability of membrane rece…
Mark Bathe · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2019 · $193,750 — PROJECT SUMMARY Targeted delivery of therapeutic gene editing CRISPR ribonucleoprotein (RNP) complexes to cells offers major opportunities for next-generation therapies, however, realization of this goal requires a vehicle to protect and direct CRISPR RNPs to their targeted cells and tissues. Curren…