Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $5,639 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 · $427,652 — PROJECT SUMMARY / ABSTRACT The overall goal of this grant has been to understand in molecular details the action of apolipoproteins (apos) and lipoproteins in health and disease. The current focus is on human apoA-I, the major protein of plasma high-density lipoproteins (HDL, a.k.a. good cholesterol…
NURAN ERCAL · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · 2019 · $387,500 — Project Summary/ Abstract Surgery is the only effective treatment for cataract, the most common cause of blindness worldwide. Although cataract surgery is routine and generally considered safe, it is costly and carries risks of serious complications (e.g., capsular opacification or rupture). Thus, t…
BABU L TEKWANI · SOUTHERN RESEARCH INSTITUTE · 2019 · $742,840 — PROJECT SUMMARY/ABSTRACT Development of dormant hypnozoites in the hepatic tissues, which may cause malaria relapse weeks to months after the initial infection, poses the major challenge for treatment & control of vivax malaria. 8- Aminoquinolines (8-AQs) are the only antimalarial drugs active agai…
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2019 · $796,846 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
Gregory J Dodge · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2019 · $61,226 — Abstract: This project aims to expand the mechanistic understanding of the initial membrane-associated steps of bacterial glycoconjugate biosynthesis. Membrane protein structures are critically underrepresented in the protein data bank (PDB), and remain difficult targets for purification, character…
Subhash C. Chauhan · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2019 · $196,478 — The long-term goal of the proposed research proposal is to develop a targeted paclitaxel nanotherapy that can be used for the treatment of pancreatic cancer (PanCa) in combination with Gemcitabine (GEM). Although many conventional and combinational chemotherapies exist to treat PanCa, significant si…
NIGEL W BUNNETT · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2019 · $67,010 — PROJECT SUMMARY This proposal examines the mechanisms by which G protein-coupled receptors (GPCRs) signal pain. Chronic pain is a hallmark of disease, a side effect of therapy, and a major cause of suffering. Although GPCRs mediate all aspects of nociception and are major therapeutic targets, the me…
ZHENG-RONG LU · CASE WESTERN RESERVE UNIVERSITY · 2019 · $356,444 — The goal of this project is to develop smart dual-targeted lipid ECO/siRNA self-assembly nanoparticles to target oncogenic long non-coding RNAs (lncRNAs) as a novel therapy to treat metastatic and drug-resistant triple negative breast cancer (TNBC). Metastasis and drug resistance are the main causes…
Jared Michael Newton · BAYLOR COLLEGE OF MEDICINE · 2019 · $28,091 — Immunosuppressive microenvironments are a major hindrance to current immunotherapy applications in solid tumor cancers. Patients with human papillomavirus (HPV)-induced oropharyngeal cancer (OPC) are an excellent example of this as marked elevations in systemic immunosuppression result in less than …
Jin Xie · UNIVERSITY OF GEORGIA · 2019 · $473,515 — Abstract Photodynamic therapy (PDT) has gained much attention as a relatively new cancer treatment modality. PDT has a favorable toxicity profile compared to radiotherapy. Meanwhile, it does not incur resistance, and can be applied to previously irradiated tissues. However, the use of PDT in the cl…
William Olaf Hancock · PENNSYLVANIA STATE UNIVERSITY, THE · 2019 · $321,178 — PROJECT SUMMARY Intracellular cargo transport along microtubules is driven by kinesin and dynein motors that work antagonistically to precisely target cargo to specific cellular locations. Although the mechanisms underlying bidirectional transport have received considerable attention, a number of v…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2019 · $675,953 — ABSTRACT: Cystic fibrosis (CF) is conferred by any of ≥1200 known mutations in the gene encoding the CFTR, an ion transporter protein, but in principle, a single gene therapy agent that delivers expression of functional CFTR could treat. Prior attempts to do so have used adeno-associated viral or li…
CYRUS R SAFINYA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2019 · $295,216 — Project Summary/Abstract The current level of research activity involving gene therapy with either synthetic vectors (carriers) or engineered viruses is unprecedented. Liposomes are the most widely studied nonviral carriers worldwide for nucleic acid (NA) and drug delivery applications. Cationic lip…
Jian-Xing Jay Ma · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2019 · $333,000 — DESCRIPTION (provided by applicant): Choroidal neovascularization (CNV) in AMD is a leading cause of vision loss. Oxidative stress and inflammation in the retina and RPE are believed to play important pathogenic roles in CNV. The canonical Wnt pathway is known to mediate inflammation, angiogene…
ASMA NUSRAT · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2019 · $460,345 — Abstract The gastrointestinal epithelium plays a central role in maintaining and coordinating mucosal homeostasis and immunity. Intestinal epithelial barrier compromise in mucosal wounds is seen in many pathologic states that encompass inflammatory bowel diseases, ischemia, mechanical injury and sur…
Shabaana A. Khader · WASHINGTON UNIVERSITY · 2019 · $408,644 — DESCRIPTION (provided by applicant): Approximately one-third of the world's population is latently infected with Mycobacterium tuberculosis (Mtb) with a 10% risk of developing pulmonary tuberculosis (TB) over their lifetime. Global efforts to combat TB are hampered by the emergence of drug-resi…
Lucas William Erickson · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2019 · $52,868 — PROJECT SUMMARY/ABSTRACT The CRISPR/Cas9 system has quickly emerged as the most robust gene editing tool yet discovered. Many early papers employing this system have utilized a plasmid that encodes the Cas9 protein and the guide RNA (sgRNA). These plasmids are typically delivered in viral shells tha…
Forrest M Kievit · UNIVERSITY OF NEBRASKA LINCOLN · 2019 · $447,459 — PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI) is the leading cause of disability and death in people under 45 with approximately 10 million new cases each year worldwide. The effects of TBI can be severe, including neurocognitive, physical, and psychosocial impairment. There remains a signi…
Martina Ralle · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $254,898 — Project Summary X-ray fluorescence microscopy (XFM) has emerged as powerful tool to visualize metals within cells or tissue. Using X-ray microprobes, investigators can now produce elemental maps of biological material at the cellular and subcellular levels. Determining the elemental distribution and…