Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Juliane Nguyen · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $482,859 — PROJECT SUMMARY/ABSTRACT Exosomes were originally thought of as the cellular “waste-disposal system.” It is now known that they are important for intercellular communication and contribute to the pathogenesis of several diseases including cancer, neurodegenerative disease, and autoimmunity. Once sec…
James F. Collins · UNIVERSITY OF FLORIDA · 2019 · $514,815 — Project Summary Iron is an essential nutrient for humans, yet excess iron is toxic. As such, iron overload and iron deficiency result in severe homeostatic perturbations. Iron overload is most frequently associated with hereditary hemochromatosis (HH), which afflicts ~1:250 adults in the U.S. Tissue…
Michael Dennis Raleigh · WASHINGTON UNIVERSITY · 2019 · $193,057 — PROJECT SUMMARY. The goal of this CEBRA is to integrate cutting-edge concepts from nanotechnology, immunology, and addiction to develop nanovaccines to treat heroin and prescription opioid abuse and prevent fatal overdose. Opioid abuse is a major national emergency in the US with an enormous cost in…
Bruce Shapiro · DIVISION OF BASIC SCIENCES - NCI · 2019 · $1,312,847 — Recently we developed a new type of RNA nanostructure that forms a truncated tetrahedron. The structure was built from our hexameric ring where 4 sides of the tetrahedral structure each contain the hexmeric ring, but each ring contains 3 H-shaped crossover connectors to the other rings. This type of…
Aleksandra Elzbieta Sikora · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2019 · $272,001 — ABSTRACT Neisseria gonorrhoeae (Ng) is a human-specific pathogen and the etiological agent of gonorrhea, a sexually transmitted infection with a significant global health burden of ~78 million new cases annually. While often asymptomatic, untreated gonorrhea can lead to pelvic inflammatory disease, …
JAY W HEINECKE · VANDERBILT UNIVERSITY MEDICAL CENTER · 2019 · $262,515 — We propose to investigate the structural basis of the interaction of LCAT with HDL. We will complement these in vitro studies with analyses of HDLs of subjects with LCAT deficiency. Because these patients have very low HDL-C levels but apparently little increased cardiovascular risk, their HDL might…
S. Munir ALAM · DUKE UNIVERSITY · 2019 · $340,189 — Induction of broadly neutralizing antibodies (bnAbs) is a critical unmet goal of HIV vaccine development. BnAb DH511 is of high interest as a vaccine lead due to its very high breadth and the high in vivo protective potency of MPER bNAbs. Key challenges for inducing DH511-like bnAbs are: (a) the low…
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $14,689 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
Gregory M Lanza · WASHINGTON UNIVERSITY · 2019 · $672,844 — MM responds well to initial chemotherapy but relapses occur in the majority of MM patients and nearly all patients die from progressive disease within 6 years. We hypothesize that targeted nanotherapy will disrupt the transformative influence of cMyc on myeloma progression and significantly impact…
SonBinh TheBao Nguyen · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $237,000 — PROJECT SUMMARY Cholesterol has been linked to several cardiac and brain vascular diseases, dementias, diabetes, and cancer. Emerging data suggests that such diseases can be traced back to an imbalance in cholesterol transport mediated by high-density lipoproteins (HDLs), specifically attributed to …
Zheng-Yi Chen · MASSACHUSETTS EYE AND EAR INFIRMARY · 2019 · $789,370 — Project Summary and Relevance Application of genome editing based therapy requires efficient delivery of editing agents into disease-relevant tissues and cells. Identification of novel delivery materials targeting somatic cells will greatly facilitate the advance of editing based therapy strategies …
Marco Pravetoni · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2019 · $1,537,430 — Project Summary Opioid use disorders (OUD) are a national public health emergency with more than 115 fatal overdoses occurring each day in the USA. Annually, the economic burden of OUD is over US$78 billion. Several medications are available for treating OUD, but their access is limited and efficacy…
Sashwati Roy · INDIANA UNIVERSITY INDIANAPOLIS · 2019 · $393,750 — ABSTRACT Persistent unresolved inflammation impairs diabetic wound healing. The function and fate of wound monocyte/macrophages (mϕ) hold the key to the outcome of wound inflammation. This proposal builds on observations originating from live functional wound macrophages (wmϕ) and wound fluid derive…
Pranoti Mandrekar · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2019 · $376,875 — DESCRIPTION (provided by applicant): Activation of liver resident macrophages and increased pro-inflammatory cytokine production is a hallmark in the pathogenesis of alcoholic liver disease (ALD). Alcohol-induced oxidative stress plays an important role in macrophage activation. Stress induced …
MICHAEL P CZECH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2019 · $582,900 — Abstract The overarching long term goal of our laboratory is to understand and exploit how adipose tissues exert powerful control over whole body glucose tolerance and insulin sensitivity. Small amounts of mouse brown (BAT) or human “Beige” adipocytes transplanted into recipient mice can improve glu…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2019 · $286,228 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
Masanori Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $602,965 — DESCRIPTION (provided by applicant): Uncontrolled activation of macrophages promotes various inflammatory diseases. The most devastating diseases linked to macrophage activation include atherosclerosis, a global health burden. To discover novel regulators of macrophage activation as therapeutic…
Dana Ashley Hill · CHILDREN'S RESEARCH INSTITUTE · 2019 · $395,349 — DESCRIPTION (provided by applicant): Studies of inherited cancer syndromes have provided unique opportunities to uncover and explain important cellular pathways with broad relevance to both sporadic cancers and human development. This proposal studies the cancer predisposition syndrome original…
SEBASTIAN JOYCE · VETERANS HEALTH ADMINISTRATION · 2019 — The overarching goal of my research program is to understand the molecular mechanisms of immune surveillance mediated by tissue-resident memory T cells that patrol the mucosal barrier of the lungs to control infectious diseases and cancers. My laboratory is best recognized for its c…
JAMES K TSURUTA · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $76,258 — ABSTRACT Lipid shelled perfluorocarbon (PFC) microbubbles ranging from 0.5 to 8 microns in diameter have been approved by the FDA to enhance the contrast of blood for diagnostic ultrasound imaging. The micro scale of ultrasound contrast agents limits them to the bloodstream, eliminating the enhanced…