Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
John B Barnett · EXESALIBERO, INC. · 2019 · $102,161 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
JENNIFER A DOUDNA · UNIVERSITY OF CALIFORNIA BERKELEY · 2019 · $800,300 — PROJECT SUMMARY / ABSTRACT CRISPR-Cas9 has demonstrated incredible potential to provide clinical benefit, but the challenge of delivery currently hinders therapeutic use of genome editing in vivo. Use of viral vectors and lipid nanoparticles has established the viability of in vivo genome editing, b…
Mark Andrew Borden · UNIVERSITY OF COLORADO · 2019 · $352,275 — The development of new pharmaceuticals for the treatment of brain cancer and neurological disease has outpaced our ability to deliver them safely, largely due to the blood-brain barrier (BBB). Bypassing the BBB to access the brain parenchyma is often highly invasive, involving surgery to remove part…
Dmitri Simberg · UNIVERSITY OF COLORADO DENVER · 2019 · $343,881 — DESCRIPTION (provided by applicant): While having tremendous potential as a therapeutic tool, clinical use of engineered nanoparticles has also been associated with serious safety concerns. Following systemic injection, nanoparticles interact with blood proteins causing life-threating hypersens…
Elena Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $664,893 — Project Summary This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of macrophage-derived extracellular vesicles (EV), precursors of microcalcifications, contributing to the biomechanical instability of the vulnerable atheroscleroti…
Pamela K Woodard · WASHINGTON UNIVERSITY · 2019 · $624,055 — PROJECT SUMMARY This proposal is a first-in-human trial of a newly developed nanoparticle PET radiotracer that targets the natriuretic peptide receptor C (NPR-C), with the long-term potential to help to determine which asymptomatic patients with carotid artery stenosis might require surgery. Our res…
Sangpil Yoon · UNIVERSITY OF NOTRE DAME · 2019 · $248,999 — Project Summary / Abstract Dr. Sangpil Yoon is a postdoctoral scholar at the Department of Biomedical Engineering at the University of Southern California (USC). He has developed an innovative technique for the intracellular delivery of macromolecules using high frequency ultrasound. Dr. Yoon is a p…
David Lawrence Danley · PARABON NANOLABS, INC. · 2019 · $225,220 — PROJECT SUMMARY/ABSTRACT The human immune response to HIV-1 is complex with the virus demonstrating remarkable evasion mechanisms. Significant progress has recently been made in HIV vaccine development based on early-stage clinical trials and subsequent investigations into the nature of protective i…
Fekadu Kassie · UNIVERSITY OF MINNESOTA · 2019 · $352,275 — PROJECT SUMMARY Lung cancer is the leading cause of cancer-related death in the United States. About 90% of lung cancer cases are associated with genetic/epigenetic changes induced by tobacco smoke (TS). Although all types of lung cells could be affected by TS, the effect on stem cells is particular…
WILLIAM E. CARSON · OHIO STATE UNIVERSITY · 2019 · $543,192 — PROJECT SUMMARY RNA nanotechnology has progressed rapidly during the past several years. This nanotechnology includes the integration of multiple functional modules into one nanoparticle, of which the scaffolds, ligands, therapeutics, and regulators can be composed mainly or exclusively of RNA. We …
Marco Brotto · UNIVERSITY OF SOUTH FLORIDA · 2019 · $433,699 — Project Summary Diabetes is a leading cause of death in the US and worldwide with deleterious consequences to the musculoskeletal system. Regardless of glycemic control, diabetes in skeletal muscle manifests with altered metabolism leading to progressive skeletal muscle loss, functional decline, fas…
Mary Jane Thomassen · EAST CAROLINA UNIVERSITY · 2019 · $311,326 — DESCRIPTION (provided by applicant): Pulmonary granuloma formation is a key feature of sarcoidosis, a chronic disease of unknown etiology. Sarcoidosis has been linked to environmental risk factors (wood-burning stoves, fireplaces and firefighting) that favor carbon nanotube formation. We have shown …
GEORGE K. GITTES · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2019 · $374,150 — PROJECT SUMMARY AND RELEVANCE An ideal solution to the treatment or cure of diabetes mellitus would be the formation of new functioning β-cells from the patient’s own tissues, thereby avoiding the need for transplant immunosuppression. Abundant recent data has suggested that α-cells are a likely sou…
Clyde Jason Wright · UNIVERSITY OF COLORADO DENVER · 2019 · $490,696 — PROJECT SUMMARY Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and predicts poor pulmonary and neurodevelopmental outcomes. Despite the well-documented association between inflammation and BPD, no safe and effective anti-inflammatory therapies to prevent BP…
Monica Maki Burdick · OHIO UNIVERSITY ATHENS · 2019 · $428,636 — Abstract! Engineered nanomaterials (ENMs) are being increasingly used in industrial and biomedical applications. It is estimated that there are currently more than 1,800 nanomaterial-based products on the market, with more than 770 in the United States alone. This widespread use has raised concerns …
Runhua Runa Liu · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2019 · $204,188 — Project Summary Background: Triple-negative (estrogen receptor [ER]/progesterone receptor [PR]/human epidermal growth factor receptor 2 [HER2]-negative) breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Approximately 34% of patients with TNBC will experience distant recurrence wi…
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2019 · $382,600 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
WILLIAM M ATKINS · UNIVERSITY OF WASHINGTON · 2019 · $299,338 — Project Summary P-glycoprotein (P-gp) is an ATP-dependent efflux transporter that plays a critical role in drug and xenobiotic distribution, drug-drug interactions, and drug-nutrient interactions. Efforts to modulate P-gp activity to control cellular drug resistance or to modulate the action of exis…
Young-wook Jun · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2019 · $202,851 — ABSTRACT Monitoring dynamic protein-protein interactions (PPIs) in situ has been a topic of interest due to the importance of PPIs in cell signaling regulation and implications in therapeutic interventions. In this proposal, we introduce a new PPI method based on nanotechnology-assisted magnetic co-…
Reyad A Elbarbary · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2019 · $395,786 — Abstract Impaired or delayed fracture healing is a clinical problem that affects >1.5 million people in the US annually; obesity and associated type 2 diabetes (T2D) are significant and independent risk factors in this context. Nearly 34% of the US population is obese, and the number is projected to…