All Archives — Profoundd Archive

Project 1: Development of Nucleoside-Modified mRNAs Encoding Sequential HIV-1 Envelopes for Initiation of V3-glycan Neutralizing Antibody Lineages

NIH Pandemic-Era Grants · Pandemic Era Grants / 2019

Barton F. Haynes · DUKE UNIVERSITY · 2019 · $1,844,691 — Project 1: Development of Nucleoside-Modified mRNAs Encoding Sequential HIV-1 Envelopes for Initiation of V3-glycan Neutralizing Antibody Lineages A major goal of HIV-1 vaccine development is to induce broadly neutralizing antibodies (bnAbs). This IPCAVD team has immunogens that can trigger unmutate…

Signaling and Biotechology Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2019

Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2019 · $3,396 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…

Omics Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2019

Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2019 · $459,749 — Abstract: The primary function of Omics Core is to provide members of the ULARC with the expertise, resources and facilities needed for metabolomic, proteomic and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment…

Research Project I - Vesicant-Induced Skin Injury

NIH Pandemic-Era Grants · Pandemic Era Grants / 2019

DONALD R GERECKE · RBHS-SCHOOL OF PUBLIC HEALTH · 2019 · $846,767 — Research Project 1. Vesicant-induced Skin Injury Key personnel: Donald Gerecke, Ph.D., Associate Professor, Rutgers University School of Pharmacy Jeffrey D. Laskin, Ph.D., Professor, Rutgers University School of Public Health Project Summary/Abstract Sulfur mustard (bis-2-chloroethyl sulfide, SM) an…

Vaccine and Treatment Evaluation Unit at Saint Louis University

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2024 · $1,189,190 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…

Development of a Cross-Protective New World Encephalitic Alphavirus Subunit Vaccine

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

DAVID E CLEMENTS · HAWAII BIOTECH, INC. · 2024 · $203,325 — 7. Project Summary/Abstract The encephalitic New World alphaviruses (NWAVs), consisting of Eastern, Venezuelan and Western Equine Encephalitis Viruses (EEEV, VEEV and WEEV, respectively), are transmitted by mosquitoes through rodent or bird hosts and have caused significant periodic epizootic outbre…

Biodefense Training Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $175,294 — ABSTRACT This is a fourth competitive renewal of our highly successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on bio…

Building Libraries with Chemical Diversity for Screening

NIH Pandemic-Era Grants · Pandemic Era Grants / 2024

John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2024 · $902,657 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…

Development of a Cross-Protective New World Encephalitic Alphavirus Subunit Vaccine

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

DAVID E CLEMENTS · HAWAII BIOTECH, INC. · 2023 · $204,264 — 7. Project Summary/Abstract The encephalitic New World alphaviruses (NWAVs), consisting of Eastern, Venezuelan and Western Equine Encephalitis Viruses (EEEV, VEEV and WEEV, respectively), are transmitted by mosquitoes through rodent or bird hosts and have caused significant periodic epizootic outbre…

Vaccine and Treatment Evaluation Unit at Saint Louis University

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2023 · $855,721 — Saint Louis University (SLU) seeks to expand its service to the Vaccine and Treatment Evaluation Unit (VTEU) network providing resources and expertise to help the network achieve its objectives of evaluating vaccines, preventive biologics, therapeutics and diagnostics for infectious diseases. Dr. Da…

Biodefense Training Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $165,520 — This is a third competitive renewal of our very successful Biodefense Training Program (BTP) for predoctoral students; first funded in 2004, prior to the building of the Galveston National Laboratory (GNL) in 2008. Since then, there has been an explosive growth of research at UTMB on biodefense-rela…

Building Libraries with Chemical Diversity for Screening

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

John Beutler · DIVISION OF BASIC SCIENCES - NCI · 2023 · $798,286 — We established MTAs with three of the four NIGMS-funded Chemical Methodologies & Library Developments (CMLD) (Boston University, University of Kansas, and University of Pittsburgh). These three centers alone have provided over 15,000 samples of known structure. Each CMLD has a distinct approach to l…