Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
BLANCA I RESTREPO · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2024 · $887,558 — ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is a leading infectious disease and cause of death worldwide. The growing burden of drug-resistant (DR)-TB is complicating TB treatment. Early diagnosis of TB with drug susceptibility testing (DST) is critical for successful tr…
Harris R Perlman · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $799,322 — Project Summary/ Abstract The aim of the Robert H. Lurie Comprehensive Cancer Center Flow Cytometry Core Facility is to provide analysis and cell sorting to enhance scientific interaction and productivity within Northwestern University’s research community. This is accomplished by allowing access to…
Ryan P Bennett · OYAGEN, INC. · 2024 · $298,000 — PROJECT SUMMARY This R43 proposal answers the call of the RFA PA-22-176 for assay development and chemical probe screening by addressing the unmet need for development of antiviral treatments for Ebola patients through an innovative high-content small molecule screen for antagonists of the Ebola VP4…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2024 · $3,374,001 — Overall Project Summary/Abstract: Molecular mechanisms of filoviral-host interactions The family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), are zoonotic pathogens that cause outbreaks of severe human disease and require biosafety level 4 (BSL4) containment for study. Re…
Gregg A Dean · COLORADO STATE UNIVERSITY · 2024 · $466,724 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
ROBERT A DAVEY · WASHINGTON UNIVERSITY · 2024 · $357,893 — Core C – Project Summary/Abstract Core C provides support for high biocontainment work to Research Projects 1 (RP01), RP02, RP03 and Core B. Work is prioritized through Core A. Core personnel bring unique expertise in molecular biology, cell biology and animal disease modeling for Ebola and Marburg …
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2024 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Colleen B Jonsson · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $1,295,544 — PROJECT ABSTRACT The proposed Antiviral & Antimicrobial Countermeasures Discovery & Development Core (herein abbreviated as A2CD2C) will facilitate biomedical research targeted toward the discovery and/or development of countermeasures for prophylactic or therapeutic treatment of human biosafety le…
RONALD B CORLEY · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $538,414 — Administrative Core Summary The NEIDL Administrative Core provides the leadership, organizational structure, and direction of an established management plan that sustains the resources and infrastructure of the NEIDL at the highest level. This enables us to meet our mandate as a member of NIAID’s na…
David Gillum · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $285,994 — understanding of biosafety and biosecurity personnel and scientific researchers (a specialized part of the U.S. scientific workforce) with oversight responsibilities or research involving Potential Pandemic Pathogens (PPPs) and Dual Use Research of Concern (DURC) in various sectors (academic, indust…
Ferenc Livak · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,450,610 — The mission of the CCR LGI Flow Cytometry Core in Building 37 (FC37) is to offer up-to-date instrumentation and technical expertise to CCR investigators to assist cancer research. The core provides full-scale, state-of-the-art flow cytometry services including analytical sample acquisition, data ana…
Parizad Torabi-Parizi · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $460,497 — Coronavirus disease 19 (COVID-19) is a rapidly growing health threat in the United States with a fatality rate ten times greater than with seasonal influenza. The virus is highly transmissible and has rapidly infected large numbers of people in China, in several European countries, and now in the US…
ELIZABETH ANN FITZPATRICK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $882,711 — The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) provides a vast array of services that support the discovery and development of countermeasures for biodefense and emerging infectious agents with unmet medical needs. Central to this mission is the su…
Kevin Michael Tuohey · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $1,953,496 — Core 3: Environmental Health and Biosafety Regulations and Requirements Abstract The Environmental Health and Biosafety Regulations and Requirements (EHBRR) Core includes three components: Environmental Health and Safety, Emergency Management, and Occupational Medicine. The Core is integrated with c…
Patricia Veronica Aguilar · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $297,388 — Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases…
Lijun Rong · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $787,393 — Summary Ebola virus disease (EVD) is caused by an infection with a group of viruses within the genus Ebolavirus. There are at least five species of Ebolavirus, Ebola virus (Zaire, EBOV), Ebola Sudan (SUDV), Bundibugyo virus (BDBV), Reston virus and Tai Forest virus (TAFV). Infections with these viru…
Tomoko Makishima · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $647,643 — PROJECT SUMMARY/ABSTRACT Lassa virus (LASV) infection causes Lassa Fever (LF), a hemorrhagic fever endemic to West Africa. Up to 30% of LASV infection survivors develop sudden onset hearing loss after clearing the initial acute disease, and in some cases also develop dizziness and imbalance, similar…
SUSAN Leslie Favrot MCLELLAN · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $6,000 — The NIH has long recognized the steady decline in the physician-scientist workforce. We have great concern over the critical shortage of physician-scientists in the field of Infectious Disease. We are equally concerned about assuring the next generation of leaders needed to combat the emergence of n…
Nancy Jean Sullivan · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $7,541,758 — PROJECT SUMMARY/ABSTRACT The National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University (BU) was established to generate essential information about new and reemerging infectious pathogens and the diseases they cause, to facilitate development of vaccines, therapeutics, and diag…
Junki Maruyama · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $249,000 — Lassa virus (LASV) is endemic in West African countries and causes outbreaks of LF annually. Although LASV is one of the most alarming pathogens from a public health perspective, there are few effective vaccines or therapeutics against LF. LASV must be handled at biosafety level 4 (BSL-4), due to …