Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
JILL E HUTCHCROFT · PURDUE UNIVERSITY · 2023 · $82,914 — Flow Cytometry Shared Resource (FC-SR) Project Summary The Purdue Flow Cytometry Shared Resource (FC-SR) provides advanced cell and particle analysis, cell sorting and single cell genomic capabilities to members of the Purdue University Center for Cancer Research (PCCR). The FC-SR has made major i…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $215,210 — BSL-4 CORE (Core B): PROJECT SUMMARY/ABSTRACT The pathogenesis of Ebola virus (EBOV) disease is characterized by a dysregulated immune response that includes the suppression of the innate immune system leading to “immune paralysis” and paradoxically activation of inflammatory pathways characteristic…
Gregg A Dean · COLORADO STATE UNIVERSITY · 2022 · $461,662 — Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDR…
Daniel E Voth · UNIV OF ARKANSAS FOR MED SCIS · 2022 · $7,975,000 — The University of Arkansas for Medical Sciences (UAMS) is an Institution of Emerging Excellence in a small state with a large rural, underserved population that suffers disproportionately from infectious diseases. UAMS has committed to expanding infectious disease basic research through faculty recr…
Lijun Rong · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 · $795,165 — Summary Ebola virus disease (EVD) is caused by an infection with a group of viruses within the genus Ebolavirus. There are at least five species of Ebolavirus, Ebola virus (Zaire, EBOV), Ebola Sudan (SUDV), Bundibugyo virus (BDBV), Reston virus and Tai Forest virus (TAFV). Infections with these viru…
Linden T Hu · TUFTS UNIVERSITY BOSTON · 2022 · $5,147,109 — (a) Overview The past two years have shown that infectious diseases are global threats, revealing an urgent need to improve preparedness to combat unknown pathogens. Furthermore, the alarming increase in infections caused by antimicrobial resistant (AMR; see glossary, below) pathogens in recent year…
Yoshihiro Izumiya · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $505,165 — Deregulation of genome interactions through mutations at regulatory elements or mutation of responsible cellular nuclear enzymes result in multiple disorders. Although the significance of proper genomic-genomic interactions has been seen from disease phenotypes, the underlying molecular mechanisms o…
CHRISTOPHER C BRODER · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2022 · $5,616,110 — Project Summary (OVERALL) The pathogenic henipaviruses (Nipah and Hendra) are distinguished among the paramyxoviruses by virtue of their uniquely broad tropism and impressive lethality. These viruses can infect animals across 6 orders of mammals, causing an often fatal disease in 11 species includin…
Maria Isabel Giraldo · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $395,000 — The most recent outbreak of Ebola virus (EBOV) in West Africa reached alarming numbers of infections and deaths, prompting extensive efforts to develop antiviral strategies; however, none have thus far been approved for use in humans. The development of antiviral drugs is mostly based on designing c…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $5,291,771 — PROJECT 3 – ABSTRACT The goal of this project is to discover novel henipavirus inhibitors. Henipavirus is a deadly airborne respiratory pathogen that are under-researched and poorly understood. Antiviral therapy is urgently needed for henipaviruses for pandemic preparedness. We will achieve the goal…
STEPHEN C JAMESON · UNIVERSITY OF MINNESOTA · 2022 · $192,369 — Summary Core B NME Mouse Core Our published studies suggest that mice with more physiological exposure to natural mouse microbes have immune systems that are a better match for the immune system in humans: In contrast to typical “clean” laboratory mice (which are maintained in barrier facilities to …
David G Thanassi · STATE UNIVERSITY NEW YORK STONY BROOK · 2022 · $2,933,079 — PROJECT SUMMARY/ABSTRACT The Laboratory for Comparative Medicine (LCM) at Stony Brook University is a recently constructed, state-of- the-art animal biosafety level 3 (ABSL3) facility. The LCM is actively engaged in basic, translational, and preclinical research on SARS-CoV-2, the viral agent of the…
Thierry Diagana · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $56,163,625 — OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, non-governmental, academic and private sectors to develop an arsenal of countermeasures against the existential threat of v…
Patricia Veronica Aguilar · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $296,935 — Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $1,179,782 — PROJECT SUMMARY/ABSTRACT Nipah virus (NiV) causes febrile encephalitis and severe respiratory disease in humans with fatality rates as high as 100% in some outbreaks (average ~ 75% for outbreaks over the last decade). There are currently no licensed vaccines or therapies for combating NiV disease. N…
Alexander Bukreyev · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $361,188 — BSL-4 CORE (Core B): PROJECT SUMMARY/ABSTRACT The pathogenesis of Ebola virus (EBOV) disease is characterized by a dysregulated immune response that includes the suppression of the innate immune system leading to “immune paralysis” and paradoxically activation of inflammatory pathways characteristic…
Colleen B Jonsson · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2022 · $2,021,906 — Project Summary The University of Tennessee Health Sciences Center (UTHSC) proposes to upgrade facilities and broaden research services in the existing UTHSC Regional Biocontainment Laboratory (RBL) located in Memphis, TN to support internal and external investigators in basic and translational rese…
ROBERT A DAVEY · PURDUE UNIVERSITY · 2022 · $637,035 — A research team from Purdue University and Texas Biomedical Research Institute is in pursuit of important new approaches to validate the host V-ATPase. The project goal to define antiviral drug leads for diseases caused by Ebola and Marburg filoviruses. Many viral pathogens bind to specific factors …
Junki Maruyama · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $63,240 — PROJECT SUMMARY/ABSTRACT This career development award will help fill in the knowledge and skills in basic virological research of Risk Group 4 agents, which need to be handled in the highest containment laboratory (BSL-4). This is essential for the goal to become an independent researcher as an exp…
Cheng Huang · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $240,000 — PROJECT SUMMARY/ABSTRACT Several mammalian arenaviruses cause severe and fatal zoonotic diseases in humans, for which vaccines and treatments are very limited. Lassa virus (LASV) is the causative agent for Lassa fever (LF) that is currently endemic in Western Africa. Despite its importance to public…