Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Alexander Niclas Freiberg · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $200,000 — ABSTRACT Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics …
Ling Zhao · UNIVERSITY OF TENNESSEE KNOXVILLE · 2022 · $445,534 — Project Summary/Abstract Obesity remains one of the biggest public health challenges worldwide. Obesity is associated with various comorbidities, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, leading to a shorter lifespan and higher medical costs. Recent studies have indicate…
Yu-Hua Tseng · JOSLIN DIABETES CENTER · 2022 · $632,230 — Project Summary/Abstract Obesity and its metabolic sequelae are rapidly increasing in the United States and worldwide, leading to high morbidity and mortality in type 2 diabetes, cardiovascular disease, and certain cancer. Under the current pandemic, obesity has been recognized as a key risk factor …
Hannah Kim Frank · TULANE UNIVERSITY OF LOUISIANA · 2022 · $279,000 — Project Summary Bats host many viruses, seemingly without disease, that cause lethal infections in humans and other non-bat species, including rabies, Marburg fever virus and SARS-related coronaviruses. A greater understanding of the bat immune system – how it responds to viruses, how it differs fro…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $1,543,607 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $350,149 — Abstract Zoonotic coronaviruses (CoV) are responsible for three major epidemics/pandemics in the 21st century, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003 and the Middle East Respiratory coronavirus (MERS-CoV) in 2012. In Dec 2019, a third novel CoV designated SARS-CoV-2 emerge…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $521,027 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
JENNIFER A DOUDNA · J. DAVID GLADSTONE INSTITUTES · 2021 · $519,750 — Project Summary We aim to determine the molecular basis for SARS-CoV-2 viral packaging and to develop a screening strategy to identify inhibitors of this key step in the coronavirus infection cycle. Selective packaging of the viral genome, over more abundant transcripts, involves specific interactio…
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2021 · $283,713 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Christopher F Basler · GEORGIA STATE UNIVERSITY · 2021 · $5,392 — The Middle East respiratory syndrome coronavirus (MERS-CoV), is a highly pathogenic, zoonotic, non-segmented, positive-sense RNA virus related to the severe acute respiratory syndrome coronavirus (SARS CoV) and SARS-CoV-2 that can spread from person to person. The potential threat posed by zoonotic …
Eric A Nelson · SOUTH DAKOTA STATE UNIVERSITY · 2021 · $222,750 — Project Summary There is an urgent need for coronavirus (CoV) surveillance in both wildlife and livestock. As seen repeatedly, CoVs have a propensity to jump species from their bat, rodent and avian reservoirs, often to intermediate species including livestock, before infecting humans. Our knowledge…
Diane Bimczok · MONTANA STATE UNIVERSITY - BOZEMAN · 2021 · $462,348 — Summary The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious human respiratory tract pathogen that has the capacity to infect many different organ systems, including the gastrointestinal (GI) tract. The overall goal of this project is to elucidate the rol…
Philippe DUSSART · PASTEUR INSTITUTE FROM MADAGASCAR · 2021 · $134,999 — Zoonotic pathogens derived from an animal reservoir account for some 60-75% of emerging infectious diseases in humans, a disproportionate number of which take place in resource poor countries where the economic and social burden of corresponding health crises is greatest. Bats have received much att…
William A Schountz · COLORADO STATE UNIVERSITY · 2021 · $8,865 — Summary / Abstract In recent years, several bat-borne zoonotic diseases have emerged that cause substantial morbidity and mortality in humans. Many of these are caused by viruses that require the highest biosafety containment, including the ebolaviruses, Marburg virus, and Hendra and Nipah viruses. …
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $1,545,268 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
Alexander Niclas Freiberg · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $240,000 — ABSTRACT Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics …
Susan R Weiss · UNIVERSITY OF PENNSYLVANIA · 2021 · $447,637 — Middle East respiratory syndrome virus (MERS), a zoonotic lineage C Betacoronavirus discovered in 2012, has caused over 2,000 infections and more than 700 deaths. The emergence of MERS in addition to SARS highlights the public health significance of virulent, emerging coronaviruses (CoVs). MERS is d…
Christopher F Basler · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $186,654 — The Middle East respiratory syndrome coronavirus (MERS-CoV), is a highly pathogenic, zoonotic, non-segmented, positive-sense RNA virus related to the severe acute respiratory syndrome coronavirus (SARS CoV) and SARS-CoV-2 that can spread from person to person. The potential threat posed by zoonotic …
Philippe DUSSART · PASTEUR INSTITUTE FROM MADAGASCAR · 2020 · $134,977 — Zoonotic pathogens derived from an animal reservoir account for some 60-75% of emerging infectious diseases in humans, a disproportionate number of which take place in resource poor countries where the economic and social burden of corresponding health crises is greatest. Bats have received much att…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $1,702,711 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…