Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $528,448 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Samuel K Campos · UNIVERSITY OF ARIZONA · 2020 · $333,879 — Human papillomaviruses (HPVs) are the most common sexually transmitted infection. These viruses infect and replicate in mucosal and cutaneous epithelium, inducing cell proliferation as part of their replicative life cycle. High risk oncogenic HPVs caused over 500,000 cases of cervical cancer worldwi…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $495,230 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Gonzalo Izaguirre · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $252,845 — Abstract Many human pathogenic viruses exploit the host-cell proteases of the proprotein convertase (PC) family for their own benefit. The proteolytic processing of viral surface proteins is a mechanism by which viruses regulate their infectivity. The crucial role of the proteolytic regulation of vi…
Tianxin Yang · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2020 — DESCRIPTION (provided by applicant): A decade ago, (pro)renin receptor (PRR) was cloned as a new component of the renin-angiotensin system (RAS) with the capability to bind prorenin and renin to increase their catalytic activity. Soluble PRR (sPRR) is derived from the extracellular domai…
THOMAS H BUGGE · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2020 · $2,244,204 — The overall aim of this project is to understand the biochemistry, biology, and pathology of cell surface-associated proteolysis, with an emphasis on determining the contribution to the development, homeostasis, regeneration, and malignant transformation of oral tissues. Cell surface serine proteas…
Tianxin Yang · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2019 — DESCRIPTION (provided by applicant): A decade ago, (pro)renin receptor (PRR) was cloned as a new component of the renin-angiotensin system (RAS) with the capability to bind prorenin and renin to increase their catalytic activity. Soluble PRR (sPRR) is derived from the extracellular domai…
THOMAS H BUGGE · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2019 · $2,110,888 — The overall aim of this project is to understand the biochemistry, biology, and pathology of cell surface-associated proteolysis, with an emphasis on determining its contribution to the development, regeneration, and malignant transformation of oral tissues. Cell surface serine proteases as regulat…
SERGIO FAZIO · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $533,826 — Summary Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulatory protein that binds to the low-density lipoprotein receptor (LDLR), induces its degradation, and increases LDL-cholesterol (LDL-C) levels. Thus, PCSK9 is a therapeutic target to increase LDLR expression and reduce plasma L…
HENRY DANIELL · UNIVERSITY OF PENNSYLVANIA · 2019 · $726,730 — DESCRIPTION: Injectable biopharmaceuticals produced in current systems are prohibitively expensive and are not affordable for a large majority of the global population. Recent studies have shown that bioencapsulation of protein drugs in plant cells are protected in the stomach. Commensal microb…
Tianxin Yang · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2019 · $566,573 — (Pro)renin receptor (PRR) binds prorenin/renin in vitro to increase their catalytic activity and therefore is postulated to be a regulator of renin. Soluble PRR (sPRR) residing in the extracellular domain of PRR is produced by furin or ADAM19-dependent cleavage process and has been widely studied as…
Stephen Leppla · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $971,268 — Anthrax toxin protective antigen protein (PA) binds to receptors on the surface of mammalian cells, is cleaved by cellular proteases, forms an oligomer, and transports two other toxin proteins, lethal factor (LF) or edema factor (EF) to the cytosol. EF is a potent calmodulin-dependent adenylyl cycla…
Valder R. Arruda · CHILDREN'S HOSP OF PHILADELPHIA · 2019 · $426,871 — Project 4 - Abstract Novel approaches to enhance the biologic activity of FVIII and FIX are critical endeavors with potential for improving protein- and gene-based therapy for hemophilia. We have identified novel variants and new strategies that have a positive effect on the biological activity of F…
Michael P Hutchens · PORTLAND VA MEDICAL CENTER · 2024 — Acute cardiorenal syndrome (cardiorenal syndrome type 1, CRS1) frequently follows the most common cause of admission to a Veterans Health Administration inpatient facility, acute cardiovascular disease. Although CRS1 seems to self-resolve in most cases, development of chronic kidney disease often oc…
Swati S More · UNIVERSITY OF MINNESOTA · 2024 · $571,020 — ABSTRACT Angiotensin-converting enzyme (ACE) plays a well-established role in regulating blood pressure in the periphery. ACE is also expressed in the brain, with high levels in the striatonigral pathway formed by medium spiny projection neurons that express the Drd1 dopamine receptor (D1-MSNs). We …
Heather A Himburg · MEDICAL COLLEGE OF WISCONSIN · 2024 · $546,000 — SUMMARY Our laboratory has recently reported sex-differences in morbidity during gastrointestinal acute radiation syndrome (GI-ARS) with adult male rats having increased susceptibility to GI-ARS than age-matched female rats. This finding is in line with a growing body of evidence from multiple labs …
ELLIOTT D CROUSER · OHIO STATE UNIVERSITY · 2024 · $236,250 — Sarcoidosis is a pulmonary and systemic granulomatous disease of unknown cause. To better understand disease mechanisms, we have recently established a novel in vitro human granuloma model that shares many structural and molecular features of the disease in human tissues, yielding novel insights int…
Anne Lyons · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $41,755 — Project Summary Adenosine monophosphate-activated kinase (AMPK) is a master metabolic regulator critical for sensing low cellular energy states and initiating catabolic activities while also inhibiting anabolic activities.1 It has become increasingly clear that spatiotemporal regulation of AMPK is k…
Xiaofeng Li · ABBRATECH, INC. · 2024 · $995,774 — Abstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even a…
JOHN P COOKE · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $705,488 — ABSTRACT Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered Vein-Chip Challenge: Increasing evidence shows that SARS-CoV-2, which is the novel coronavirus that causes COVID- 19, is able to trigger the formation of blood clots within the veins of patien…