Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Yuebing Zheng · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $380,353 — PROJECT SUMMARY This R01 application is responsive to the NIH initiative PAR-19-253 “Focused Technology Research and Development”. Assays for measuring receptor-ligand affinity are valuable in many areas of biomedical research. The “gold standard” surface plasmon resonance assay is limited to recomb…
Steven Van Dyken · WASHINGTON UNIVERSITY · 2024 · $233,250 — ABSTRACT Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and resultant coronavirus disease 2019 (COVID-19) has caused a global health crisis, surpassing 100 million infections in the United States. SARS- CoV-2 infections range from asymptomatic to respiratory failure and death, and can …
Noha Shawky · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $241,563 — Polycystic ovary syndrome (PCOS), the most common endocrine disorder in young women, is characterized by hyperandrogenemia and metabolic dysfunction. PCOS women who become pregnant may have offspring born with low birth weight (LBW), associated with increased risk for cardiovascular (CV) disease (…
Monica Kraft · UNIVERSITY OF ARIZONA · 2024 · $287,587 — During the first cycle of our AADCRC program, our project focused primarily on Surfactant Protein A (SP-A), a known innate immune modulator that exhibits important anti-inflammatory effects in asthma. In this renewal, we show preliminary data that SP-A binds the interleukin (IL)-6 receptor and disru…
Tara F Carr · UNIVERSITY OF ARIZONA · 2024 · $224,703 — The overall goal of this Asthma and Allergic Diseases Cooperative Research Center (AADCRC) proposal is to elucidate the mechanisms by which the innate immune system affords protection against viral-induced exacerbations in asthma. In the renewal of our AADCRC program, we will continue to focus on th…
Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $119,920 — PROJECT 2: ABSTRACT Project 2 is based on evidence that lung cancer patients have higher susceptibility to SARS-CoV-2 infection and increased risk of severe disease and mortality. This increased vulnerability is likely due to a combination of factors, including immune-suppressing effects of the canc…
Sumant Singh Chugh · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $556,406 — Abstract The COVID 19 pandemic has been associated with the development of proteinuria in up to 40% of hospitalized patients. This cardinal manifestation of kidney disease is most likely related to effects of the extensive cytokine storm in these patients on glomeruli, the filtering units of the kid…
Yiping Zhu · UNIVERSITY OF ROCHESTER · 2024 · $192,500 — ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), has caused a global health crisis. Currently effective vaccines are available to prevent SARS- CoV-2 infection, but our options for the treatment of SARS-CoV-2 infec…
Preetish Kadur Lakshminarasim · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $715,989 — ABSTRACT Human induced pluripotent stem cells (iPSCs) can be used to generate 3-dimensional lung organoid structures. However, most lung organoid studies have focused on human iPSC-derived lung epithelial subtypes. They have not to date included human iPSC-derived endothelial cells and systematical…
Ronald G Collman · UNIVERSITY OF PENNSYLVANIA · 2024 · $243,750 — The Oropharyngeal Microbiome in COVID-19 Summary (Abstract) SARS-CoV-2 first infects the oropharynx and upper respiratory tract, where it either remains localized and is cleared, or propagates to the lower respiratory tract where it can progress to pneumonia and respiratory failure. Several patient …
KENNETH E BERNSTEIN · CEDARS-SINAI MEDICAL CENTER · 2024 · $338,801 — A long sought goal of medical research is to identify ways to increase the effectiveness of the immune response. Here, we present a means of increasing myeloid cell function by increasing cell expression of angiotensin converting enzyme (ACE). We show that 1) under natural circumstances in both huma…
LICY LORENA YANES CARDOZO · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $700,565 — Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PCOS is diagnosed by elevated androgens, ovulatory dysfunction, and polycystic ovaries. Women with PCOS have a high prevalence of cardiovascular risk factors (CRFs), such as obesity, insulin resistance …
Heather Hickman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $102,819 — The emergence of SARS-CoV-2 in human populations in 2019 has resulted in a global pandemic with staggering morbidity and mortality. In humans, coronavirus-induced disease 2019 (COVID-19) is characterized by decreased lung function and increased pro-inflammatory cytokine production. As the immune m…
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $369,431 — The overarching goal of this project is to determine the role of angiotensin converting enzyme 2 (ACE2) in the diabetic gut, how it impacts hyperglycemia and glycemic variability, and thus contributes to the pathogenesis of diabetic retinopathy (DR). The protective arm of the renin angiotensin syste…
Alexander H Flannery · UNIVERSITY OF KENTUCKY · 2024 · $99,759 — PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in sepsis-associated acute kidney injury (SA-AKI). The candidate is currently an Assistant Professor at the University of Ke…
Ivan Marazzi · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $747,848 — PROJECT SUMMARY Infection causes inflammation, which contributes to pathogen clearance and survival of the host organism. However, failure to regulate the inflammatory response can often lead to multiple organ damage and lethality for the host. In the current COVID-19 pandemic caused by the severe a…
Eric D Lazartigues · LSU HEALTH SCIENCES CENTER · 2024 · $538,276 — With prevalence as high as 55% for individuals aged 55 and older in United States, hypertension (HTN) is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. The role of the brain renin-angi…
Monica Kraft · UNIVERSITY OF ARIZONA · 2024 · $1,431,641 — In this AADCRC program renewal, we will focus on three critical and understudied innate immune factors and how they impact viral infections in asthma: the anionic phospholipids of surfactant (palmitoyl- oleoyl-phosphatidylglycerol, POPG, and phosphatidylinositol, PI), Toll interacting protein (Tolli…
ANTHONY W ORVEDAHL · WASHINGTON UNIVERSITY · 2024 · $933,000 — PROJECT SUMMARY/ABSTRACT The host inflammatory response is a double-edged sword that must vigorously defend against pathogens, but also requires restraint to prevent unintended injury to the host. The Cytokine Storm Syndrome (CSS) represents a state of unbridled inflammation that can be triggered b…
Andrea Lee Frump · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $768,905 — PROJECT SUMMARY This proposal builds on the scientific premise that right ventricular (RV) maladaptive remodeling is a major contributor to RV failure and mortality in pulmonary hypertension (PH). Despite its importance, no RV-directed therapies exist. The goal of this proposal is to is to identify …