Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
DIRK HOMANN · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $418,396 — ABSTRACT The possibility that infection with SARS-CoV-2 may trigger diabetes emerged as a concern in mid 2020. We have addressed this issue by developing a research roadmap that identified complementary areas of investigation according to several broad topics in the realm of relevant basic biomedica…
Takako Araki · UNIVERSITY OF MINNESOTA · 2023 · $391,475 — PROJECT SUMMARY COVID-19–related extra-pulmonary damage is common and may even be observed in patients with mild COVID- 19 symptoms. There is an urgent and immediate need to establish optimal post-infection health care strategies for these patients, yet mechanisms underlying their appearance remain …
CALVIN J KUO · STANFORD UNIVERSITY · 2023 · $393,500 — ABSTRACT The COVID-19 pandemic, engendered by the novel coronavirus SARS-CoV-2, is a grave threat to public health, with lung infection and respiratory failure. However, the intestine is also targeted by SARS-CoV-2, as many patients present with GI symptoms and the SARS-CoV-2 receptor angiotensin-co…
Sumant Singh Chugh · RUSH UNIVERSITY MEDICAL CENTER · 2023 · $626,464 — Abstract The COVID 19 pandemic has been associated with the development of proteinuria in up to 40% of hospitalized patients. This cardinal manifestation of kidney disease is most likely related to effects of the extensive cytokine storm in these patients on glomeruli, the filtering units of the kid…
MARY ANN Y JABRA-RIZK · UNIVERSITY OF MARYLAND BALTIMORE · 2023 · $193,125 — PROJECT SUMMARY Recently, individuals with COVID-19 were found to harbor replicating SARS-CoV-2 inside salivary epithelial cells resulting in inflammation, architectural distortion, and atrophy of minor and major salivary glands. We have previously demonstrated the importance of histatin-5, a secret…
Todd B Reynolds · UNIVERSITY OF TENNESSEE KNOXVILLE · 2023 · $508,939 — Candida albicans and related Candida spp. are responsible for ~400,000 invasive infections/year, which have an ~50% mortality rate. A crucial virulence trait of C. albicans, and other fungi, is the ability to diminish their detection by their hosts. The cell wall carbohydrate ß(1,3)-glucan is an imp…
Ekaterina Koroleva · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2023 · $278,500 — Accumulating evidence suggest that SARS-CoV-2 infection induces tissue pathology in multiple organs in addition to the lung, including, among others, intestine, heart, liver, kidney, and brain. Furthermore, SARS- CoV-2 infection can exacerbate many chronic inflammatory diseases. However, mouse model…
Yiping Zhu · UNIVERSITY OF ROCHESTER · 2023 · $231,000 — ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), has caused a global health crisis. Currently effective vaccines are available to prevent SARS- CoV-2 infection, but our options for the treatment of SARS-CoV-2 infec…
ELLIOTT D CROUSER · OHIO STATE UNIVERSITY · 2023 · $196,875 — Sarcoidosis is a pulmonary and systemic granulomatous disease of unknown cause. To better understand disease mechanisms, we have recently established a novel in vitro human granuloma model that shares many structural and molecular features of the disease in human tissues, yielding novel insights int…
Yuebing Zheng · UNIVERSITY OF TEXAS AT AUSTIN · 2023 · $379,953 — PROJECT SUMMARY This R01 application is responsive to the NIH initiative PAR-19-253 “Focused Technology Research and Development”. Assays for measuring receptor-ligand affinity are valuable in many areas of biomedical research. The “gold standard” surface plasmon resonance assay is limited to recomb…
Matthew Scott Kelly · DUKE UNIVERSITY · 2023 · $241,500 — ABSTRACT SARS-CoV-2, the etiological agent of COVID-19, has been responsible for more than 600 million reported infections and 6.5 million deaths globally. Although several antivirals, monoclonal antibodies, and immunomodulatory treatments improve patient outcomes, mortality from COVID-19 remains un…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2023 · $388,750 — Project Summary/Abstract This R01 entitled, “Development and characterization of engineered therapeutic antibodies against SARS-CoV- 2”, builds on our project infrastructure, expertise, and experience in characterizing viral-host factor interactions in negative strand RNA viruses. Since originating …
HENRY DANIELL · UNIVERSITY OF PENNSYLVANIA · 2023 · $739,713 — PROJECT SUMMARY/ABSTRACT Current Protein Drugs (PD) are prohibitively expensive ($140 billion in top ten PDs, >75% of global GDP). One third of global population earning <$2 per day can’t afford any PD. Insulin, a five-decade old drug, is still unaffordable, even in developed countries, as illustra…
Afsar Raza Naqvi · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $581,037 — Abstract Coronavirus disease 2019 (Covid-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infecting non-vaccinated and vaccinated people. Covid-19 clinically affects multiple organs including oral mucosa where SARS-CoV-2 replication occurs to deposit v…
GILL DIAMOND · TULANE UNIVERSITY OF LOUISIANA · 2023 · $764,413 — Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a life-threatening illness with multi-system involvement in a subset of infected individuals. Oral and nasopharyngeal (NP) epithelial cells express the SARS-CoV-2 receptor…
Shelli Farhadian · YALE UNIVERSITY · 2023 · $1,230,201 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Philippe Youkharibache · DIVISION OF BASIC SCIENCES - NCI · 2023 · $40,912 — A significant part of my recent research efforts is focused on studying self-association determinants of molecular systems as revealed by their structural symmetries at several levels: from proteins assemblies to their protein supersecondary structures constituents (protodomains) [Youkharibache 2019…
Sonja Best · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $482,755 — The SARS-CoV-2 global pandemic has a continuing demand for greater understanding of the mechanisms of disease and the development of therapeutics to complement success in vaccination. Several mouse models have emerged that can be used, albeit with limitations, as models of severe SARS-Cov2 infection…
Natalie Shaw · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $172,894 — We confirmed increased ACE2 mRNA and protein expression and functional activity (via a fluorometric assay) in SMCHD1 KO human placode cells. We are now conducting molecular and genomic studies, including RNA-seq, Hi-C, and SMCHD1 ChIP-seq, studies to investigate the precise mechanism underlying epig…
Peter Skene · SEATTLE CHILDREN'S HOSPITAL · 2023 · $815,639 — Abstract The immune system is composed of many heterogeneous cell types that respond in a synergistic manner to mount both immediate and long-lived immunity against pathogens. The complexity of the immune system necessitates an integrated view of multiple biological modalities to understand differen…