Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Swati S More · UNIVERSITY OF MINNESOTA · 2023 · $580,098 — ABSTRACT Angiotensin-converting enzyme (ACE) plays a well-established role in regulating blood pressure in the periphery. ACE is also expressed in the brain, with high levels in the striatonigral pathway formed by medium spiny projection neurons that express the Drd1 dopamine receptor (D1-MSNs). We …
REINHARD LAUBENBACHER · UNIVERSITY OF FLORIDA · 2023 · $762,062 — PROJECT SUMMARY/ABSTRACT A key feature of the COVID-19 infection is the vast inter-individual heterogeneity in the severity of the infection. The complex biological mechanisms that underlie this variability remain mostly obscure. We propose to provide a mechanistic understanding of this susceptibil…
Ralph S Baric · WASHINGTON UNIVERSITY · 2023 · $1,197,841 — Project Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that was first isolated in Wuhan China in December, 2019. SARS-CoV-2 is the cause of coronavirus disease 2019 (COVID-19), which is now a pandemic and has caused more than 1.3 mi…
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2023 · $815,811 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination reduces the risk of SARS-CoV-2 infection and severe disease, but almost half of hospitalized breakthrough cases are in immunocompromised individuals. HIV infection is an independent risk factor for severe COVID-19, hospitalization, and mortality. Immunoc…
Noam A Cohen · PHILADELPHIA VA MEDICAL CENTER · 2023 — ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximately 3.5% and a wide range of morbidity outcomes negatively impacted by pre-existing conditions. Given the prevalence of p…
Steven Van Dyken · WASHINGTON UNIVERSITY · 2023 · $194,584 — ABSTRACT Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and resultant coronavirus disease 2019 (COVID-19) has caused a global health crisis, surpassing 100 million infections in the United States. SARS- CoV-2 infections range from asymptomatic to respiratory failure and death, and can …
Xuyi Yue · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · 2023 · $177,500 — PROJECT SUMMARY The coronavirus disease2019 (COVID-19) pandemic is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). New COVID-19 cases and COVID-19 related deaths continue to rise rapidly and no effective drugs or vaccines are currently available…
GR Scott Budinger · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $742,194 — PROJECT SUMMARY This application directly stems from our recent publication in Nature in which we analyzed bronchoalveolar lavage (BAL) fluid from 88 patients with critical SARS-CoV-2 pneumonia using a combination of flow cytometry, bulk transcriptomic profiling of flow sorted alveolar macrophages a…
Spyridon Stavrou · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2023 · $199,375 — A viral pathogen associated with severe pneumonia was recently identified as the cause of a global pandemic that has resulted in the death of over two million people. This viral pathogen was later classified as a coronavirus that was subsequently named Severe Acute Respiratory Syndrome Coronavirus 2…
Monica Kraft · UNIVERSITY OF ARIZONA · 2023 · $1,431,641 — In this AADCRC program renewal, we will focus on three critical and understudied innate immune factors and how they impact viral infections in asthma: the anionic phospholipids of surfactant (palmitoyl- oleoyl-phosphatidylglycerol, POPG, and phosphatidylinositol, PI), Toll interacting protein (Tolli…
Kyeong-Ok Chang · KANSAS STATE UNIVERSITY · 2023 · $735,037 — PROJECT SUMMARY Human coronaviruses generally cause the common cold, a mild upper respiratory illness, however, global outbreaks of new human coronavirus infections with severe respiratory disease have periodically emerged from animals. These include Severe Acute Respiratory coronavirus (SARS-CoV), …
Xiaofeng Li · ABBRATECH, INC. · 2023 · $296,100 — Abstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even a…
Alexander Minchev Tsankov · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $126,750 — PROJECT SUMMARY COVID-19 disease, caused by the novel coronavirus SARS-CoV-2, is a global health threat due to its rapid spread, morbidity, and mortality. It is estimated that at least 25% of severe COVID-19 disease survivors experience persistent respiratory complications. This underscores the need…
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $369,431 — The overarching goal of this project is to determine the role of angiotensin converting enzyme 2 (ACE2) in the diabetic gut, how it impacts hyperglycemia and glycemic variability, and thus contributes to the pathogenesis of diabetic retinopathy (DR). The protective arm of the renin angiotensin syste…
Sanjana Dayal · UNIVERSITY OF IOWA · 2023 · $673,720 — Project Summary Infection with severe acute respiratory syndrome novel corona virus (SARS-CoV-2) causes COVID-19. In severe cases, COVID-19 leads to profound inflammation (“cytokine storm”) followed by coagulopathy and a prothrombotic-state with progression to multiple organ failure. Several cytokin…
Kurt Jarnagin · SYNBAL, INC. · 2023 · $566,896 — Abstract Phase I/II Synbal and the La Jolla Institute for Immunology (LJI) are combining efforts to create breakthrough new tools for COVID-19 research to enhance research and drug development for COVID-19 disease. We aim to create a state-of-the-art set of humanized mouse strains susceptible to SAR…
Brittany Butts · EMORY UNIVERSITY · 2023 · $192,780 — ABSTRACT The purpose of this study is to determine the extent to which vascular risk factors are associated with biomarkers of Alzheimer’s disease (AD) risk over time in middle aged adults with heart failure with preserved ejection fraction (HFpEF). Mid-life cardiovascular risk factors contribute to…
Ronald G Collman · UNIVERSITY OF PENNSYLVANIA · 2023 · $203,125 — The Oropharyngeal Microbiome in COVID-19 Summary (Abstract) SARS-CoV-2 first infects the oropharynx and upper respiratory tract, where it either remains localized and is cleared, or propagates to the lower respiratory tract where it can progress to pneumonia and respiratory failure. Several patient …
Chiara Giannarelli · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2023 · $783,846 — PROJECT SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health concern and despite the fast-track development of vaccines and the imminent prospective of new antiviral drugs, is expected to become ende…
Devdoot Majumdar · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $211,108 — PROJECT SUMMARY: Devdoot Majumdar, PhD, Research Project Leader (RPL) The mRNA vaccines against SARS-CoV-2 proved unexpectedly efficacious, but also require a series of booster immunizations to remain protective. Global deployment of these vaccines has been slow, particularly in low- and middle-inco…