Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Taia Wang · STANFORD UNIVERSITY · 2024 · $187,845 — PROJECT 1: SUMMARY As established through decades of research in protective immunity against infectious pathogens, achieving durable immunity against SARS-CoV-2 will require specific functional properties of antibodies, B cells and T cells that need to be defined through detailed repertoire studies.…
Philip A Mudd · WASHINGTON UNIVERSITY · 2023 · $581,189 — ABSTRACT Neutralizing antibodies are critical for protection from infectious diseases. The lymph node (LN) germinal center (GC) is the site where B cells undergo antibody affinity maturation and develop into long-lived plasma cells – key events that are required for the development of highly effecti…
Brian T. Cunningham · STANFORD UNIVERSITY · 2023 · $739,473 — Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to-child HIV transmission, and a required element of routine diagnostic testing to make people aware of their HIV status. …
Renren Wen · VERSITI BLOOD HEALTH, INC. · 2023 · $659,871 — Abstract COVID-19 severity/lethality is associated with a dysfunctional inflammatory immune response and a hyper- engagement of pathways driving hemostasis and thrombosis, but the link between the two manifestations is not understood. Compared to patients with mild symptoms, severe COVID-19 patients…
Priyamvada Acharya · DUKE UNIVERSITY · 2023 · $762,466 — Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike COVID-19, caused by SARS-CoV-2, has devasted global health and economics. Vaccines are being deployed worldwide to gain control of the pandemic, although emergence of fast-spreading “variants of concern” (VO…
David Huw Davies · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $592,289 — PROJECT SUMMARY/ABSTRACT In this proposal we will define molecular and cellular mechanisms of different combinations of known adjuvant components MPLA (a TL4 agonist), CpG (a TLR9 agonist), agonists of cGAS-STING and NOD1/2 pathways, and a squalene-in-water emulsion (AddaVAX™). Our overall Aim is to…
Ernesto Guccione · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $280,223 — SUMMARY Long-term protection from viral infections is mediated by both the humoral and cellular immune pathways. Multiple Myeloma (MM) is the second most common hematological malignancy in the US and is characterized by clonal plasma cell production, resulting in immune suppression and recurrent ba…
MARK L DELL'ACQUA · UNIVERSITY OF COLORADO DENVER · 2023 · $509,277 — Plasticity in the hippocampus leads to persistent changes in synaptic structure and function that underlie learning and memory. Intracellular Ca2+ signaling pathways activated downstream of NMDA receptors (NMDAR) and L-type voltage-gated Ca2+ channels (LTCC) contribute to changes synaptic function t…
Ya-Wen Chen · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $705,521 — Project Summary In early 2020, a new virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), generated headlines due to its unprecedented rate of transmission. SARS-CoV-2 caused the first reported cases of coronavirus disease 2019 (COVID-19) in December 2019 and continues to spread wor…
Sizun Jiang · BETH ISRAEL DEACONESS MEDICAL CENTER · 2023 · $474,960 — PROJECT SUMMARY/ABSTRACT Distinctive host-pathogen interactions and adaptations are the cornerstones of co-evolution between eukaryotes and their viral pathogens. Given the rapid replication and mutation rates of RNA viruses within their host, understanding these intra-host interactions in their nat…
Catarina E Hioe · JAMES J PETERS VA MEDICAL CENTER · 2023 — Project Summary/Abstract The COVID-19 pandemic, which is caused by SARS-CoV-2, a novel coronavirus first detected in November-December 2019, has inflicted millions of deaths worldwide. In the US, the outbreak is affecting millions of lives. The VA hospitals, including the James J. Peters VA Medical…
Declan McCole · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2023 · $378,139 — SUMMARY/ABSTRACT The global coronavirus disease 2019 (COVID-19) pandemic has affected over 70 million individuals in 220 countries (www.who.int). A major clinical confounder of COVID-19 is the lack of knowledge of host factors that promote susceptibility to SARS-CoV-2 infection and more severe gastr…
James B Munro · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2023 · $502,500 — SUMMARY Influenza A virus (IAV) hemagglutinin (HA) is the canonical example of a class-I viral fusion protein, and thus provides an ideal model system for understanding the fusion mechanisms of many different viruses. Numerous other viral envelope glycoproteins, including the SARS-CoV-2 spike, are b…
Emanuela Marina Bruscia · YALE UNIVERSITY · 2023 · $618,689 — PROJECT SUMMARY Macrophages (MΦs) kill microorganisms, engulf dead cells and debris, and regulate the immune response. They are thus gatekeepers of tissue health, including the lungs. The lung-tissue-resident MΦs (TR-MΦs) are the interstitial and alveolar MΦs, which have complementary but distinct f…
Houjian Cai · UNIVERSITY OF GEORGIA · 2023 · $221,972 — Summary/Abstract SARS-CoV-2 has caused the deaths of millions of people globally. Effective antiviral therapeutic treatment options are urgently needed. CRISPR-mediated genome editing has provided a very promising avenue for treatment of a variety of genetic diseases. Particularly, the CRISPR-Cas13 …
Merav Socolovsky · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2023 · $515,212 — Project Summary Protein synthesis and ribosome biogenesis are the two most energy -intensive processes in a cell, resulting in their regulation through tight controls. EpoR, a member of the cytokine receptor superfamily, and its downstream mediator Stat5, are essential for erythropoiesis. The curren…
WEI CHEN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $195,000 — Abstract The long-term goal of our research is to develop effective therapies against SARS-CoV-2-elicited disease Covid-19. SARS-CoV-2 spike (S) protein binds to its cognate receptor, angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine proteas…
Irina Budunova · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $247,411 — COVID-19 continues to be a global catastrophe despite development of anti-SARS-CoV-2 vaccines. This is due to the worldwide limited vaccine availability, vaccination hesitancy, and the emergence of new variants of SARS- CoV-2. Moreover, there is a lack of complete knowledge about SARS-CoV-2 biology,…
Matthew Bogyo · STANFORD UNIVERSITY · 2023 · $236,100 — Project Summary Current strategies to overcome virus outbreaks are focused on development of effective vaccines as well as novel treatments that can either block infection or prevent mortality from the resulting disease. One of the strategies that has shown promise is the use of serum from patients …
YUPING WANG · LOUISIANA STATE UNIV HSC SHREVEPORT · 2023 · $219,000 — COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as the greatest threat to global health and significantly impact pregnant women worldwide. COVID-19 infection during pregnancy is associated with substantial risk of increases in maternal morbidity and mort…