Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
WEN-YUAN E HSIEH · UNIVERSITY OF COLORADO DENVER · 2023 · $613,169 — PROJECT SUMMARY Emergence of the highly transmissible SARS-CoV-2 B.1.617.2 (Delta) variant and return to in-person learning is rapidly increasing the COVID-19 disease incidence and transmission rate in children. Therefore, it is critical to protect younger children. Toward this goal, ongoing COVID-1…
Ariel Jade Kuhn · UNIVERSITY OF WISCONSIN-MADISON · 2023 · $68,684 — PROJECT SUMMARY Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease (COVID-19), has spurred an unprecedented global pandemic. Infection surges necessitate new therapeutic agents that are effective against a rapidly changing virus. Antiviral…
Ricardo Rajsbaum · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2023 · $471,011 — The Severe Acute Respiratory Syndrome Coronavirus 2 (CoV-2) belongs to a family of pathogenic enveloped RNA viruses of the family Coronaviridae. The ongoing pandemic has caused a public health emergency worldwide, accompanied by dire health and economic consequences. There is evidence suggesting tha…
CHRISTOPHER M WATERS · UNIVERSITY OF KENTUCKY · 2023 · $232,586 — Acute lung injury and its more severe form, acute respiratory distress syndrome (ARDS), are devastating illnesses with high rates of incidence and mortality. Patients with acute lung injury are typically provided supplemental oxygen using positive pressure mechanical ventilation, but this can lead t…
YAN XIANG · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2023 · $193,750 — Summary The novel coronavirus SARS-CoV-2 causes the COVID-19 pandemic. The virus infects through the respiratory tracts. While most COVID-19 patients display no or mild clinical symptoms, a small percentage develop severe immune-mediated pathological complications, which could lead to injury and fai…
Jack T. Stapleton · IOWA CITY VA MEDICAL CENTER · 2023 — We propose to characterize SARS-CoV-2 interactions with human T cells and examine how this influences adaptive and humoral immunity. SARS-CoV-2 (CoV2) is the etiologic agent of COVID-19, the third highly pathogenic coronavirus to emerge as a human pathogen since 2000. CoV-2 causes disease by dysregu…
Zhenyu Zhong · UT SOUTHWESTERN MEDICAL CENTER · 2023 · $410,000 — Project Summary A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, whereas its imbalance results in genome instability that precipitates cellular damage and breach of homeostasis. Re…
Asrar B. Malik · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $739,004 — PROJECT SUMMARY / ABSTRACT Coronavirus disease 2019 (COVID-19) is a devastating systemic inflammatory syndrome caused by the coronavirus SARS-CoV-2 which has resulted in over 500,000 deaths in the US during the past year, with this high rate of mortality being attributed in large part to the develop…
Weishan Huang · LOUISIANA STATE UNIV A&M COL BATON ROUGE · 2023 · $203,149 — Project Summary/Abstract SARS-CoV-2, the etiological pathogen of COVID-19, has resulted in a pandemic. There remains an urgent need for innovative technologies which facilitate the development of affordable antiviral precision medicine. SARS-CoV-2 is an enveloped virus, and the structure of the tri…
Harris H Wang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $452,375 — PROJECT SUMMARY The ability to synthesize gene- and pathway-sized DNA is a key tool in functional genomics. Many applications of gene synthesis call for the generation and testing of sequence variants containing multi-site mutations. Unfor- tunately, current approach to produce such constructs still…
HAFIZ AHMED · GLYCOMANTRA, INC. · 2023 · $296,637 — Project Summary/Abstract The COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is a global pandemic with catastrophic consequences for healthcare systems and populations. The increased morbidity and mortality in older persons and those with diabetes (12-22%) and h…
Chandan Guha · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2023 · $682,293 — Abstract Radiation-Induced Immune Dysfunction (RIID) is a critical component of both acute and delayed effects of radiation exposure, which causes a multi-organ failure (MOF) syndrome, operationally divided based upon timing of clinical manifestations, as acute radiation syndrome (ARS) and delayed e…
Elke BergmannLeitner · THOMAS JEFFERSON UNIVERSITY · 2023 · $170,141 — PROJECT SUMMARY As COVID-19 pandemic continues with the evolution of new strains, we acknowledge the groundwork that has been done evaluating maternal immunity following COVID-19 vaccine or disease exposure in pregnancy, and passive transmission of antibodies in cord blood and breastmilk. There rema…
EDWARD D CHAN · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2023 — The clinical outcome for patients with severe COVID-19 remains poor due to the lack of highly efficacious treatment for such individuals. Finding a better remedy for them is an important niche and immediate unmet need. The aim of this pre-clinical project is to substantiate the therapeutic effect of…
Melodie Lynn Weller · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2023 · $190,625 — Project Summary | Role of Salivary Gland Localized SARS-CoV-2 Infection in Oral Tolerance & Immunization Efficacy Over 5 million individuals in the United States have been diagnosed with systemic acute respiratory syndrome coronavirus-2, SARS-CoV-2, infections 1. One of the primary unanswered quest…
Eliver Ghosn · EMORY UNIVERSITY · 2023 · $192,880 — Project Summary Mounting an effective antibody response against SARS-CoV-2 is key to fight off the infection. However, not all antibodies produced against the virus are protective. Recent studies show that high titers of immunoglobulin G (IgG) against the SARS-CoV-2 Spike (S) protein during natural…
Wendy PrudhommeOMeara · DUKE UNIVERSITY · 2023 · $202,190 — In many developing countries, the Covid-19 pandemic has had limited direct impact, including Kenya, which as of 5 March 2021, has recorded only 107,329 cases and 1,870 deaths owing to Covid19. Although this limited clinical impact is in part the result of strict travel and movement restrictions and …
John YJ Shyy · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $673,114 — Project Summary Vascular endothelial cell (EC) metabolism is essential for functional endothelium, and maladapted energy use severely affects EC health. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy status and homeostatic function. Our preliminary studies showed that ener…
Duane R. Wesemann · BRIGHAM AND WOMEN'S HOSPITAL · 2023 · $7,828,320 — OVERALL SUMMARY Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a devastating human threat. While successful vaccine programs are underway, genetic drift and immune escape have already begun to subvert immunity, with more variants likely to continue to emerge. Moreover, the rates of …
Caitlin Jaime Couch · EMORY UNIVERSITY · 2023 · $36,384 — ABSTRACT As of August 2021, the coronavirus disease COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has infected more than 200 million people across the globe, causing more than 600,000 deaths in the USA and 4.2 million worldwide. Though vaccines have become ava…