Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
ALBERTO ASCHERIO · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2023 · $477,028 — PROJECT SUMMARY The highest priority recommended by NINDS for clinical Parkinson’s research is to define “the features and natural history of prodromal Parkinson disease (PPD), including the events that underlie phenoconversion to clinically manifest PD, and biomarkers or other determinants of prodr…
Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2023 · $1,943,312 — OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that ca…
THOMAS E DEVER · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2023 · $2,009,782 — We study the mechanism and regulation of protein synthesis in eukaryotic cells. Of special interest are the regulation of protein synthesis by GTP-binding (G) proteins and protein phosphorylation. In addition, we are studying unusual post-translational modifications of the factors that assist the ri…
Ruili Huang · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2023 · $637,571 — The Tox21 Programs federal partners include the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA) and NIH, with leadership from NCATS and the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). These agencies work together…
Stefano Marenco · NATIONAL INSTITUTE OF MENTAL HEALTH · 2023 · $4,711,045 — Currently, the Human Brain Collection Core (HBCC) has 1307 brains available for distribution, with the following diagnoses (numbers of subjects listed in parentheses): attention deficit disorder (24); anxiety disorders (27); autism spectrum disorders (5); Bipolar disorder (156), Non-psychiatric cont…
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $72,183 — IDPS continues to support ongoing the Vaccine Research Centers (VRC) COVID-19 studies in the establishment and continued advancement of pre-exposure and post-exposure treatment modality (i.e. vaccine) studies using the rhesus macaque animal model. As a result, IDPS personnel were co-authors on two (…
Christopher H Fox · AMERICAN ASSOCIATION FOR DENTAL, ORAL, AND CRANIOFACIAL RESEARCH · 2023 · $30,000 — Project Summary The American Association for Dental, Oral, and Craniofacial (AADOCR) Bloc Travel Grant program aims to target a diverse pipeline of the dental, oral, and craniofacial research workforce by providing travel and meeting support to the most promising U.S. dental and PhD students, reside…
George Parsons Langan · UNIVERSITY OF CHICAGO · 2023 · $2,469,118 — PROJECT ABSTRACT (OVERALL) Our nation’s ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and understanding human immune responses to infection. Following bioterroris…
Dori R Germolec · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $147,440 — Our current work focuses on investigating specific cellular functions that have been demonstrated to be relevant to respiratory viral infection, including (influenza and SARS-CoV-2), susceptibility and pathogenesis by evaluating inflammatory and innate and adaptive immune responses. We are using an …
Elodie Ghedin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,439,918 — Host response to influenza infection is a complex trait that involves entire host-pathogen interaction networks of RNA transcripts, proteins, and metabolites that have an impact on cellular, tissue, and whole-organism behaviors, which ultimately define both the risk and severity of infection. This p…
BRIAN KELSALL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $17,750 — Demonstrating where SARS-CoV-2 infects and replicates in intestinal epithelium in vivo has been difficult to demonstrate conclusively. Therefore, we stained limited intestinal tissues from infected human autopsy samples for SARS-CoV2 both by immunofluorescence using antibodies to the SARS-CoV2 spik…
Duck-Yeon Lee · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $573,911 — 1. Core utilization and accomplishments - A total of 54 people from 23 laboratories have used for the facility services and instruments. - Support investigators by implementing or developing methods for 1) mass measurement of intact proteins and organic compounds (a total of 3,158 samples from 23 la…
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $5,332,395 — The NIEHS Clinical Research Branch has continued to expand its scope of support for clinical and translational studies. The NIEHS Clinical Research Unit (CRU) has recorded over 11,000 patient encounters with over 95% patient satisfaction. Additional staff have been hired to support CRU functions. …
Helen Chun-Hui Su · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $478,359 — These studies have been organized as part of a broader effort among multiple principal investigators in the Intramural Research Programs of NIAID, NIDCR, NCI, and NIAMS, as well as a research collaborative agreement with investigators at the American Genome Center/Uniformed Services University of th…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $341,507 — The global public health burden caused by SARS-CoV-2 and its resulting disease, COVID-19, has driven the rapid development of vaccines and treatment options. However, the continued emergence of novel SARS-CoV-2 variants of concern (VOC), which rapidly and globally replace earlier, previously predomi…
D. Rebecca Prevots · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $14,060 — Background Prior research has shown variability in household secondary attack rates (SAR) and transmission risks of SARS-CoV-2, which remains poorly understood. To address these questions, we conducted a household serologic study nested within a larger prospective cohort study of SARS-CoV-2 in Cost…
Emily Ricotta · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,205,774 — COVID-19 is caused by the novel SARS-CoV-2 and is associated with a hyper-inflammatory immune response which leads to severe and potentially life-threatening symptoms. Little is known about how and the extent to which COVID-19 presents in people with immunodeficiencies, but because of the known seve…
Yan Li · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2023 · $933,647 — PCF is equipped with a Thermo Fisher Orbitrap Lumos mass spectrometer with an nanoflow Ultimate 3000 HPLC, and an Agilent 6230 LC-TOF system. PCF seeks to provide high quality proteomics services on intact Protein molecular weight measurement; protein identification; protein quantification using l…
James Inglese · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2023 · $693,256 — This project includes the development of biochemical and target-focused assays based on specific protein or nucleic acid targets implicated in disease. The assay designs are considered in the context of analysis and progression strategies for evaluation of a wide range of compound classes using hi…
Matthew Wheeler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $112,846 — With the increasing complexity of large datasets, the development of novel statistical techniques that can create informative analyses, which allow scientists and decision makers, to leverage the richness of the data source is needed. This research seeks to develop methodologies that extract meanin…