Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Wing Pui Kong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $285,362 — Since there is no effective cure for COVID-19. Though the mRNA vaccines were authorized for emergency use, the durability of protection provided by these two mRNA vaccines is still a concern, given the fact that the spike-specific antibodies decline rapidly in convalescent sera of COVID patients. Du…
Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $817,413 — The objective of the Technology Core is to provide state-of-the-art, innovative -OMICs technologies for the targeted and global characterization of Project samples in a quantitative, reproducible, and efficient manner. The core brings together cutting-edge tools and the expertise of leading systems …
CALVIN J KUO · STANFORD UNIVERSITY · 2023 · $530,054 — PROJECT SUMMARY (Core B: Organoid Core) Infectious disease research is substantially hampered by lack of experimental models necessary to study interactions between pathogens and target tissues; a glaring deficiency amplified by the recent COVID-19 pandemic. The recent advent of 3D organoid methods …
Colin S. Duckett · DUKE UNIVERSITY · 2023 · $933,206 — ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1) To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted fac…
Rachel M Olson · UNIVERSITY OF MISSOURI-COLUMBIA · 2023 · $944,931 — Project Summary Core 3: Biocontainment Research Support Services Core The objective of the Biocontainment Research Support Services Core (BRSSC, Core 3) is to provide sustainable research resources that facilitate the pre-clinical development of medical countermeasures against emerging and re-emergi…
KAREN M RIDGE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $516,586 — PROJECT SUMMARY PROJECT 1 Severe viral pneumonia, due to influenza A virus (IAV) damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). The persistence of respiratory failure in patients with ARDS is a consequence of persistent inflammation and the failure of normal…
STEPHAN BOUR · DIGITAL INFUZION, INC. · 2023 · $277,285 — To provide processing for data collected and generated by the NIAID CEIRR program related to SARS-CoV-2.…
THOMAS DENNY · DUKE UNIVERSITY · 2023 · $1,830,201 — The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is to increase basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV), support the development of therapies for HIV…
TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2023 · $3,186,892 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …
CLAIRE L MOORE · TUFTS UNIVERSITY BOSTON · 2023 · $247,500 — Determining the role of alternative mRNA polyadenylation in SARS-Cov-2 replication and the host innate immune response SARS-CoV-2 infection has caused the COVID-19 pandemic, and understanding the molecular mechanisms leading to its pathophysiology is a top biomedical priority. In spite of intense re…
Keri Nicole Althoff · JOHNS HOPKINS UNIVERSITY · 2023 · $2,035,602 — PROJECT SUMMARY Approximately half of all people with HIV (PWH) in the United States (US) have one or more mental health disorder. Ending the HIV Epidemic in the US requires addressing the mental health needs of, and improving HIV treatment outcomes for, PWH with mental health disorders. The goal of…
Tené T Lewis · EMORY UNIVERSITY · 2023 · $375,646 — PROJECT SUMMARY The novel coronavirus disease 2019 (COVID-19) global pandemic was arguably one of the most devastating Public Health crises of the last century. In the US, African-Americans have been disproportionately impacted, with overall rates of infection and mortality 2 to 4 times higher than …
Margaret L Schneider · SOCIETY OF BEHAVIORAL MEDICINE · 2023 · $65,000 — PROJECT ABSTRACT The Society of Behavioral Medicine (SBM) will hold its 44th Annual Meeting & Scientific Sessions April 26-29, 2023, in Phoenix, AZ. This application seeks funding in support of meeting programming addressing the following specific aims: (1) Train attendees in the skills necessary to…
Olga Juliana Baker · GORDON RESEARCH CONFERENCES · 2023 · $15,000 — PROJECT SUMMARY This proposal requests partial support for the thirteenth Gordon Research Conference (GRC) and the third Gordon Research Seminar (GRS) entitled Salivary Glands and Exocrine Biology: Understanding the Biology of Secretory Function and Diseases of Exocrine Tissues to be held from Back …
Xueying Yang · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2023 · $143,171 — Project Summary/Abstract Effective and durable COVID-19 vaccines hold the potential to dramatically alter the COVID-19 pandemic. Remarkable achievement of COVID-19 vaccine development was observed in large, randomized-controlled trials, where several vaccines were found to be safe and efficacious in…
Gabriel Chamie · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $196,250 — Project Summary Dr. Gabriel Chamie is an infectious diseases physician and Associate Professor of Medicine in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco (UCSF). His research has focused on developing effective approaches to promote com…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2023 · $1,604,830 — West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Devel…
Carolyn Y. Fang · TEMPLE UNIV OF THE COMMONWEALTH · 2023 · $1,116,272 — Project Summary Low-Income Asian Americans (AA) with limited English proficiency (LEP) represent a meaningful proportion of low-wage frontline workers in essential service industries. Many also live in multigenerational households with crowded conditions and with their elderly relatives in ethnic ne…
Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2023 · $2,000,000 — ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Popu…
Jason Edward Shoemaker · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2023 · $253,510 — ABSTRACT Respiratory viruses, such as influenza and SARS-CoV-2, interact with distinct molecular pathways in human cells to promote virus replication and alter immune activity. When considering patient cohort variability, morbidity and mortality are often higher for women than men for select influen…