NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
DEBORAH S HASIN · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 2023 · $187,206 — Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. While most COVID-19 cases are mild or moderate, severe cases (~15%) require hospitalization, critical cases (~5%) require intensive care, and many deaths occur. Males, Blacks and Hispanics are at greater risk for COVID-19…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Helen M. Dooley · UNIVERSITY OF MARYLAND BALTIMORE · 2023 · $266,262 — PROJECT SUMMARY SARS-CoV-2, a betacoronavirus, is the etiologic agent of the ongoing COVID-19 pandemic. In response, worldwide efforts have led to the rapid development of multiple vaccine candidates that have shown efficacy in controlled clinical trials and effectiveness in the general population.…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Matthew D Cain · WASHINGTON UNIVERSITY · 2023 · $1,181,250 — PROJECT SUMMARY/ABSTRACT Viral infections are now recognized as risk factors for diseases of progressive pathological forgetting, supporting a new paradigm in neuroimmunology whereby innate immune molecules that function as modulators of a variety of normal CNS functions induce neurodegenerative dis…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
RICHARD DOUGLAS FIELDS · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2023 · $978,800 — Our long-standing interest is in neural plasticity, but we are especially interested in the involvement of glial cells in nervous system development, learning & cognition. Glia are brain cells that do not fire electrical impulses, but they communicate by releasing neurotransmitters. This enables gl…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Alan Koretsky · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2023 · $1,080,628 — We have made substantial progress towards Aims 1-5, 7&8. Specifically: a) We have demonstrated that a mutant mouse transferrin receptor binding nanobody with strong pH dependent unbinding crosses the BBB in vivo approximately 500 times more effectively than a control nanobody. b) We have demonstrate…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Kaitlyn Sadtler · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2023 · $1,156,567 — Finalizing SARS-CoV-2 Research We are finalizing the publication of our last works on COVID19 research which have all completed experimentation and are being prepared for submission to scientific journals. Please refer to prior report regarding COVID19 research projects. Identification of novel me…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Susan Buchanan · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2023 · $587,838 — CTCF and chromatin structure. Histone proteins package and condense genomic DNA into chromatin within the cell nucleus. Proteins such as the CCCTC binding factor (CTCF) help direct chromatin higher-order organization through passive and active mechanisms by imposing topological constraints, mediat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Nicole Doria-Rose · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $100,000 — During the past years, the Virology Laboratory has collaborated with other intramural NIAID labs and other external collaborators to develop a pseudovirus neutralization assay and an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). For the neutralization assay, w…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Sunny Wonsun Kim · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2023 · $419,796 — Project Summary/Abstract COVID-19 vaccines, currently available to children over six months old, are a powerful method of preventing new infections and reducing the risk of hospitalization and death due to COVID-19. However, vaccination rates among Hispanic children remain suboptimal. Lower vaccinat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Christoph Juchem · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $1,078,975 — While 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. There remains a gap in knowledge of early causes and precursor symptoms of psychiatric disorders; therefore, many children are not identified as at risk until school age, when a diagn…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Karen Marie Dobos · COLORADO STATE UNIVERSITY · 2023 · $2,751,527 — Project Summary: The Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) has been responsive to the national RBL mission to: 1) “Conduct research on biodefense and emerging infectious disease agents”; 2) “Be available and prepared to assist national, state, a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Patricia L Hibberd · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $534,998 — Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS- CoV-2) was first reported in Wuhan, Hubei Province of China in December 2019 and by early 2021, there have been more than 100 million cases of COVID-19 globally. The consequences of COVID-19 in preg…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Elizabeth Ottinger · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2023 · $1,088,000 — We have engaged in productive partnerships across various therapeutic areas in collaboration with NIH and external academic researchers and companies. During the current fiscal year, progress was made in meeting the objectives of these various collaborations. The team is further refining the high-co…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2023 · $681,593 — An ideal HIV vaccine should provide protection against all HIV-1 variants. Thus, an important aspect of HIV vaccine development is the selection of immunogens, which has to take into consideration the diversity of the different HIV clades and the identification of the critical epitopes able to induc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Elodie Ghedin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $180,957 — The major aspects of this project involve characterizing SARS-CoV-2 genetic diversity and microbial communities in the respiratory tract during infection. This involves analyzing samples from COVID-19 positive subjects, and from model animal infections. As part of this project we tackle different ty…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Jason Gall · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $5,062,451 — Coronavirus vaccines and protein reagents will be developed at the VPP. The vaccines may be manufactured through the VCMP for human clinical trials in compliance with current Good Manufacturing Practices (cGMP) and released for use in human clinical trials in healthy human volunteers. These vaccines…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Paule Joseph · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · 2023 · $66,766 — We wrote our clinical protocol for submission to IRB soon. However, through collaborations with other investigators both intramural and extramural we have published a number of manuscripts regarding this topic. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
James Cherry · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $297,252 — The project particularly aims to use state of the art instrumentation to support the needs for COVID19 research involving flow cytometry. Increasing number of NIH investigators are transitioning to complex assays for cell analysis. However, sorters currently lack the ability to translate these pan…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Laura F. Gibson · WEST VIRGINIA UNIVERSITY · 2023 · $179,050 — The Technology and Resources for Core Laboratories Core (Technology Core) of the West Virginia Clinical and Translational Science Institute (WVCTSI) supports research infrastructure critical for rapid translation of innovation to positively impact the health of West Virginians. Importantly, the Tech…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Gehan Devendra · UNIVERSITY OF HAWAII AT MANOA · 2023 · $462,752 — PROJECT SUMMARY/ABSTRACT Nearly one third of individuals who recover from acute COVID-19 will have chronic symptoms, so called ‘Post- Acute Sequelae of SARS-CoV-2’ infection (PASC). Among individuals with PASC, pulmonary complications such as persistent dyspnea and chronic cough are common. Although…