Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Alessandro Sette · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2023 · $2,391,540 — Project Summary – Overall The La Jolla HIPC team will focus on pathogens causing infectious diseases of the upper and lower respiratory tract that lead to substantial mortality and morbidity. Our approach is unique and innovative, as it focuses on defining immune signatures (IMS) of antigen-specifi…
Brian Neelon · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2023 · $185,516 — PROJECT SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has created a global public health crisis since its onset in late 2019. Although the pandemic has affected all communities, recent work suggests that socially vulnerable po…
Bashar W Badran · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2023 · $637,973 — ABSTRACT COVID exposed the critical need for new and improved treatment interventions for chemosensory (i.e. smell and taste) dysfunction. Evidence indicates that COVID-related smell loss (SL) often endures well past recovery of the initial infection and is highly associated with other long COVID ne…
Larry S. Schlesinger · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2023 · $499,999 — OVERALL ABSTRACT The Mission of the Southwest National Primate Research Center (SNPRC) is to improve the health of our global community through innovative biomedical research with nonhuman primates (NHPs). One way that it achieves this goal is by serving as a global resource to scientists that ca…
Reid Spencer Alisch · ALBANY MEDICAL COLLEGE · 2023 · $812,430 — Project Summary: DNA 5'-C-phosphate-G-3' (CpG) methylation is a covalent epigenetic modification that regulates gene expression and is highly sensitive to age and environmental factors. Critically ill patients exhibit altered circulating blood DNA methylation profiles. We have recently reported a la…
Julie Parsonnet · STANFORD UNIVERSITY · 2023 · $231,713 — PROJECT SUMMARY At the start of the COVID-19 pandemic in late 2019, an estimated 1.2 million people—including 158,500 (13%) with undiagnosed infection—were living with HIV in the United States. Since then, HIV control efforts have been complicated by disruptions to HIV testing, care-related services…
HENRY PAUL PARKMAN · TEMPLE UNIV OF THE COMMONWEALTH · 2023 · $393,626 — PROJECT SUMMARY Patients with gastroparesis often suffer with chronic symptoms that are not adequately treated due to both a lack of understanding of the underlying pathophysiology of gastroparesis and lack of effective treatments. Participation of Temple University as a clinical center in the NIDDK…
Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2023 · $32,364,105 — ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Popu…
Connie Schmaljohn · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $42,480,499 — The Integrated Research Facility - Frederick (IRF-Frederick) plays a central role in U.S. Governments high-containment research on emerging infectious diseases. In FY2023, the IRF-Frederick continued support for COVID-19 research and initiated multiple non-COVID-19 research studies. COVID-19 in vi…
Stanca M. Ciupe · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2023 · $183,401 — The emergence and re-emergence of pathogens and their impact on society has reinforced the need for integration and synergy across scientific fields and biological scales in order to advance understanding, predicting, and responding to pathogen spread. Multi-scale mathematical models that consider…
Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2023 · $12,729,140 — ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Popu…
Ivona Vasile Pandrea · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2023 · $397,500 — Abstract With more than 60 million SARS-CoV-2 -infected patients worldwide and nearly 1.5 million COVID-19-related deaths recoreded thus far (November 25), the COVID pandemic is one of the most critical global health problem ever known to humankind, and a major emergency in the US. COVID-19 disprop…
L Lee HAMM · TULANE UNIVERSITY OF LOUISIANA · 2023 · $2,396,052 — Project Summary – Overall The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of Medicine, the School of Public Health and Tropical Medicine, and…
TODD T BROWN · JOHNS HOPKINS UNIVERSITY · 2023 · $68,333 — With the success of antiretroviral therapy (ART), comorbid diseases are now the leading causes of death and disability in people living with HIV around the globe, including in low- and middle- income countries (LMIC). Large meetings are important venues for scientific exchange regarding the latest a…
Philip Murphy · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $38,242 — The aim of this project is to test the hypothesis that specific chemokines and chemokine receptors drive either immunopathology or immune control of SARS-CoV-2 infection in a mouse model. The motivation for this aim is that chemokines regulate leukocyte trafficking and covid-19 disease pathogenesis …
l aravind · NATIONAL LIBRARY OF MEDICINE · 2023 · $1,162,010 — The systematic analysis and discovery of biological conflict systems has been a major focus of research in the Aravind lab. Biological replicators, from genes within a genome to whole organisms, are locked in conflicts. Comparative genomics has revealed a staggering diversity of molecular armaments …
Yasmine Belkaid · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $5,049,028 — In response to the SARS-CoV-2 pandemic we have made the advanced technologies platforms and basic and complex informatics at CHI available for characterization of COVID-19 patient samples, as a priority ahead of our ongoing collaborative studies. The CHI program contributed to two publications and a…
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $576,947 — COVID 19 related projects: Humanized animals: We are interested in generating humanized NOD/ShiLtJ (hNOD/ShiLtJ) mice for ACE2 gene as a common NIAID resource for underlying conditions in humans for COVID-19 research. We need to change 15 amino acids (AA) in mouse gene with human AA in exon#2 (5 mu…
Geoffrey Mueller · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $753,852 — I. Origins of Allergic Disease Nothing to report this year. II. Characterization of Allergens The NMR Structure of the vicillin buried peptide (VBP) domains of Ana o 1 and Pis v 3 were determined. The NMR structure showed 4 of the cysteine residues are disulfide bonded and hold together two par…
Elizabeth Ottinger · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2023 · $161,896 — TDB has performed a number of repurposing screening efforts and the IND-directed development of GS-441524. The latter included drug metabolism and pharmacokinetic (PK) studies, human PK modeling, toxicology studies, drug product manufacture and formulation studies. TDB scientists are also contributi…