Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Harvey Bruce Pollard · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2023 · $663,601 — Abstract Over 860,000 COVID-19 deaths have occurred in the U.S., and more than 5.5 million deaths have occurred world-wide. Consequently, development of effective antiviral drugs that block infectivity and airway inflammation continue to be a global health priority. Inflammation in the COVID-19 air…
Aleksandra Elzbieta Sikora · OREGON STATE UNIVERSITY · 2023 · $719,450 — ABSTRACT Neisseria gonorrhoeae (Ng), the gram-negative bacterium responsible for the sexually transmitted infection gonorrhea, is categorized as a high-priority pathogen for research and development efforts. In the US, over 50% of Ng isolates are resistant to at least one antimicrobial and the CDC h…
Amy R. Kontorovich · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $253,500 — PROJECT SUMMARY The cardiac inflammatory disorder myocarditis is a rare but important complication following vaccination against COVID-19. Other than younger age and male sex, no risk factors for this adverse outcome have been found. Recognition of host factors that predispose to vaccine-associated …
Sanghyun Lee · BROWN UNIVERSITY · 2023 · $217,338 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 19 (COVID-19), representing a global health threat. The viral spike protein, anchored on the surface of the viral envelope as homotrimers, binds to angiotensin-converting enzyme 2 (ACE2) and me…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2023 · $14,187 — Abstract of Parent Project Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness of cancer cells. Filopodia are slender actin-filled projectio…
Kerry L Burnstein · MIAMI VA HEALTH CARE SYSTEM · 2023 — COVID-19 poses a tremendous health threat, particularly to individuals overrepresented in the US Veteran community. COVID-19 mortality is greater in men than in women; while this disparity is at least partially due to factors such as higher rates of smoking, a hormonal link is likely and can be rapi…
Dan H. Barouch · FRED HUTCHINSON CANCER CENTER · 2023 · $305,278 — This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for continuing implementation of the first COVID-19 vaccine efficacy trial “A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Study to Evaluate the…
Jeniffer Bertha Hernandez · KECK GRADUATE INST OF APPLIED LIFE SCIS · 2023 · $1,219,945 — ABSTRACT One of the “holy grails” in immunology is to be able to directly predict tight-binding variable chain antibody sequences in silico against foreign or non-self `antigenic' proteins. Immunoglobulin chain rearrangement can potentially encode approximately 1016 different variants of antibody he…
Michael R. Farzan · BOSTON CHILDREN'S HOSPITAL · 2023 · $189,627 — Abstract The central hypothesis of this proposal is that the efficacy of mRNA vaccines that deliver membrane-anchored immunogens can be improved by localizing the immunogen to extracellular vesicles (EVs, small membrane- limited structures shed by eukaryotic cells). Our rationale is that EVs provide…
MARK J SCHNITZER · STANFORD UNIVERSITY · 2023 · $889,939 — Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures. The dividends from this research will include sophisticated tools allowing selective genetic access to these cell-types, such as for imaging, optogenetic or tracing studi…
GILL DIAMOND · UNIVERSITY OF MISSISSIPPI MED CTR · 2023 · $1 — Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a life-threatening illness with multi-system involvement in a subset of infected individuals. Oral and nasopharyngeal (NP) epithelial cells express the SARS-CoV-2 receptor…
FREDERICK R BLATTNER · DNASTAR, INC. · 2023 · $648,790 — The B cell population in each individual produces an estimated 1010 different antibodies, collectively known as the antibody repertoire. This extraordinary diversity is essential for responding to the unique history of infections, vaccinations and cancer encountered over an individual’s lifetime. Co…
Masashi Tabuchi · CASE WESTERN RESERVE UNIVERSITY · 2023 · $250,000 — Project Summary/Abstract (Unchanged from the funded parent award) The idea that information processing depends on neuronal firing rate (rate coding) has long been a central dogma in neurobiology. However, other non-canonical coding schemes (temporal and “analog” codes) have been proposed to carry me…
SUBHRA MOHAPATRA · JAMES A. HALEY VA MEDICAL CENTER · 2023 — COVID-19 super pandemic is still suffering from the lack of a vaccine or infection control measures and the lack of any treatments against this new virus. One of the unique features of SARS-CoV-2 is that it has an R0=2.2 (the ability of an infected patient to spread the disease) vs R0=1 for SARS-CoV…
Hsien Wei YEH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2023 · $249,000 — úú PROJECT SUMMARY/ABSTRACT Delivering diagnostic services at the point-of-care (POC) can improve the quality of healthcare in clinics, in emergency settings, or at home, which can potentially ease hospitals’ burden, for instance, during the COVID- 19 pandemic. Precision and personalized medicine re…
Barton F. Haynes · DUKE UNIVERSITY · 2023 · $10,478,045 — Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000 deaths. With an endemic population of multipleother strains of CoVs in bats, rodents with intermediate hosts, civets and p…
Kiesha Wilson · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2023 · $248,958 — PROJECT SUMMARY/ABSTRACT The virus, SARS-CoV-2 has caused COVID-19 and claimed the lives of over 240,000 Americans and 1,270,000 people worldwide. Severe cases of the disease leads to Acute Respiratory Distress Syndrome (ARDS), sepsis and can be fatal due to pulmonary inflammation and destruction of…
John D Mountz · BIRMINGHAM VA MEDICAL CENTER · 2023 — The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic. The most important question is why some individuals produce rapid protective antibodies (Abs) and exhibit null or only mild symptoms, whereas others do not? A second urgent question is if a standard laborator…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2023 · $748,081 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
Wayne A. Marasco · DANA-FARBER CANCER INST · 2023 · $874,734 — Project Summary The emergence of the novel human betacoronavirus SARS-CoV2 in Wuhan, China in 2019 has rapidly evolved into a worldwide pandemic. Over a 100 million people have been infected and there have been several million deaths. There is also great disparity in the manner in which COVID-19 ill…