Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Hao Cheng · DREXEL UNIVERSITY · 2024 · $318,457 — Project Summary Biologic drugs and nanomedicines with conjugated polyethylene glycol (PEG) show extended circulation in the blood, increasing therapeutic efficacy. The U.S. FDA has approved more than 30 PEGylated biologics, including proteins, nucleotides, and peptides, and a few PEGylated nanomedi…
Zhengjie Zhou · UNIVERSITY OF CHICAGO · 2024 · $110,623 — Project Summary/Abstract: This proposal describes a research and career development plan for Zhengjie Zhou, Ph.D., to transit from a postdoctoral fellow to an independent investigator position. This proposal will be based on Dr. Zhou’s past years of multidisciplinary research in nanomedicine and vas…
Robbie B Mailliard · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $739,018 — ABSTRACT The CDC recommends that persons living with HIV (PWH) be vaccinated against SARS-CoV-2. However, there are minimal scientific data to support this important public health principle in relation to ongoing immune dysfunction and chronic comorbidities and the persistent HIV reservoir in antire…
Rajesh Thippeshappa · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2024 · $99,000 — Abstract/Summary: Commonly used animal models of HIV-1 include infection of macaques with Simian Immunodeficiency Virus (SIV) or Simian-Human Immunodeficiency Virus (SHIV) containing HIV envelope (Env) or reverse transcriptase. These animal models have been extremely useful in understanding HIV path…
Yoann Aldon · FRED HUTCHINSON CANCER CENTER · 2024 · $832,117 — PROJECT SUMMARY/ABSTRACT This research proposal aims to develop new immunogens for an HIV-1 vaccine by utilizing advanced protein design techniques and deep learning methods. Conventional structure-guided approaches have limitations in achieving desired structural characteristics. Therefore, this st…
Jalene Velazquez · WASHINGTON STATE UNIVERSITY · 2024 · $45,214 — PROJECT SUMMARY Survivors of Ebola virus disease (EVD) have reported a wide range of symptoms following recovery from infection. These long-term sequelae are severe enough to interfere with their daily lives and are now collectively referred to as post-Ebola syndrome (PES). Although post-viral sympt…
MICHAEL ANDREW FISCHBACH · STANFORD UNIVERSITY · 2024 · $751,181 — PROJECT SUMMARY/ABSTRACT Eliciting or suppressing an adaptive immune response has become central to oncology, autoimmunity, and infectious disease. Checkpoint inhibitors have revolutionized the treatment of cancer, while TNF inhibitors and other immune-suppressive biologics have become the standard …
Gordon Parry · AMPEDRNA BIOSCIENCES LLC · 2024 · $398,823 — Human papillomavirus (HPV) is responsible for a large proportion of global cancer cases, including head and neck, cervical and anal cancers, among others. HPV-related cancers are caused by certain high-risk strains of the virus, which can cause long-lasting infections that eventually lead to the dev…
Peter Palese · ROCKEFELLER UNIVERSITY · 2024 · $862,508 — ABSTRACT Licensed influenza vaccines commonly elicit strain-specific immunity, failing to provide protection against antigenically distinct strains with the capacity to cause pandemic outbreaks. Therefore, the development of a universal influenza vaccine with the capacity to elicit lifelong protecti…
Zhijian Jake Tu · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $738,552 — Abstract Sex is critical to the survival and evolution of sexually reproducing organisms including mosquitoes. A dominant male-determining factor (M factor) is the primary signal that controls sex-determination in mosquitoes. Nix, the M factor in the yellow fever mosquito Aedes aegypti, is the first…
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2024 · $784,041 — Summary Structural insights from our recent work provide a strong scientific premise for exploring the membrane-related components of HIV-1 envelope glycoprotein (Env), including the membrane proximal external region (MPER), the transmembrane domain (TMD) and the cytoplasmic tail (CT), for vaccine d…
Jasdave Chahal · TIBA BIOTECH, LLC · 2024 · $965,678 — Project Abstract Avian influenza A H7N9 causes severe respiratory illness with a high mortality rate, and its zoonotic capacity has raised serious concerns over the possibility of a pandemic. The value of vaccines for pandemic-potential viruses has been demonstrated by the devastating effects of COV…
Kenneth Ber Margulies · UNIVERSITY OF PENNSYLVANIA · 2024 · $793,828 — The delivery of therapeutic nucleotides to the myocardium is notoriously challenging and remains an important unmet clinical need. Based on the global success of mRNA vaccines, solid lipid nanoparticles are the most widely used vehicle for RNA delivery. We recently identified species of lipid nanopa…
Guizhi Zhu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $542,272 — Small circular mRNA vaccines Abstract: Vaccines save numerous lives each year. Conventional vaccines based on pathogens, DNA, proteins, or peptides are associated with poor pharmacokinetics, limited biostability, preexisting anti-viral-vector immunity, weak immunogenicity, or safety concerns over ge…
Andrew Mehle · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $632,278 — ABSTRACT Influenza virus is a serious public health threat causing high levels of morbidity and mortality. The annual disease burden from influenza places a significant strain on our healthcare infrastructure and economy. This is despite many efforts to control disease with yearly vaccination, antiv…
DENNIS J. HARTIGAN-O'CONNOR · TENDEL THERAPIES INC. · 2024 · $300,083 — This project will test the ability of T follicular helper (Tfh) cell-targeting “genetic adjuvants” to improve immunogenicity of an advanced HIV envelope (Env) trimer. Eliciting neutralizing antibodies (nAb) against HIV will likely be required to create effective therapeutic vaccines that attenuate H…
Anna R. Smith · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $27,783 — ABSTRACT Alpha-1 antitrypsin deficiency (AATD) is a genetic disease most commonly caused by the Z point mutation in the SERPINA1 gene, resulting in misfolded Z-AAT protein polymerization in hepatocytes, cell death, and often cirrhosis. Replacement of ZZ with wild type MM hepatocytes via liver trans…
Mark Morris Davis · STANFORD UNIVERSITY · 2024 · $2,200,798 — PROJECT SUMMARY Influenza and SARS-CoV-2 are respiratory viruses that represent a continual threat to the health of many Americans, and will likely account for 100,000 deaths and many times that number of hospitalizations in the US alone each year. The available vaccines are inadequate, with the rec…
Cecilia Maria Leal · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $376,138 — PROJECT SUMMARY RNA therapeutics hold great promise for the treatment of a number of diseases significantly impacting human health, such as chronic infections, genetic disorders, certain cancers, and presently COVID-19. The leading RNA delivery vehicles approved by the FDA, as well as being consider…
Neil King · UNIVERSITY OF WASHINGTON · 2024 · $41,075,241 — PROJECT SUMMARY – OVERALL: MACHINE LEARNING-ENABLED DESIGN OF PROTOTYPE PATHOGEN VACCINES AND ANTIBODIES We propose a highly synergistic Center focused on developing end-to-end strategies for pandemic preparedness vaccine development for bunyaviruses and paramyxoviruses. Our Center brings together …