Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Allie Greenplate · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $364,389 — Project Summary/Abstract This CCHI U19 Program aims to determine how perturbations of the human immune system leads to do durable changes that impact future immune responses. Core C of this Immune Perturbation Study Group Program application will be central to the scientific efforts of this consorti…
Michael Scott Seaman · DANA-FARBER CANCER INST · 2024 · $300,463 — SUMMARY – CORE B Neutralizing Antibody Core Recent insights into HIV-1 Env structure and function are yielding a variety of new approaches aimed at designing more advanced and novel immunogens for eliciting broadly neutralizing antibodies (bnAbs) through vaccination. As improved immunogens enter det…
Barton F. Haynes · DUKE UNIVERSITY · 2024 · $393,526 — The Administrative Core will coordinate the scientific and administrative activities of this IPCAVD Program, ensuring that the Projects and Cores function well together. In particular, it will be responsible for managing the program's financial management, program management, and coordinating Projec…
Michael C. Abt · UNIVERSITY OF PENNSYLVANIA · 2024 · $359,600 — SUMMARY: PROJECT 3 - IMMUNOLOGY The quality of the host immune response to Clostridioides difficile infection is one of the strongest predictors of disease severity. Despite the protective capacity of the host immune response, the immune parameters that promote immunity remain poorly understood. App…
BALI PULENDRAN · STANFORD UNIVERSITY · 2024 · $539,703 — ABSTRACT – Project 1 In the current proposal, we will use systems biological approaches to address two fundamental issues in vaccinology. The first issue concerns the immunology of COVID-19 vaccines, which utilize novel platforms (mRNA) or adjuvants (Matrix M used in the Novavax vaccine). The second…
Mark Morris Davis · STANFORD UNIVERSITY · 2024 · $553,826 — PROJECT SUMMARY In this technology development project, we want to continue the significant progress that we made in this last granting period and take advantage of the many opportunities that we see to make human immune organoids an indispensable system for understanding human immune responses t…
Christian Jobin · UNIVERSITY OF FLORIDA · 2024 · $77,848 — CANCER THERAPEUTICS AND HOST RESPONSE (CTHR) PROGRAM: ABSTRACT The University of Florida Health Cancer Center (UFHCC) CTHR program integrates investigators with expertise in microbiome, immunology, cancer biology, bioengineering, medicinal chemistry, and clinical trial development to advance cancer …
Marie Pancera · FRED HUTCHINSON CANCER CENTER · 2024 · $493,694 — PROJECT SUMMARY/ABSTRACT Broadly neutralizing antibodies are likely to be an important component of an HIV-1 vaccine. The HIV-1 Envelope (Env) glycoprotein is the sole target of neutralizing antibodies and has been a focus of immunogen designs. Yet diverse recombinant (rec) Envs do not display detec…
DREW WEISSMAN · UNIVERSITY OF PENNSYLVANIA · 2024 · $91,182 — SUMMARY – CORE A (Administration Core) The "mRNA Vaccines for C. difficile Suppression” program (mVACS) consists of a highly interactive team of investigators who are seeking to develop an mRNA vaccine platform to provide protection against Clostridioides difficile-associated infection and disease. …
DREW WEISSMAN · UNIVERSITY OF PENNSYLVANIA · 2024 · $311,038 — SUMMARY- PROJECT 1 (VACCINE DEVELOPMENT) Clostridioides difficile is a gram negative spore forming pathogen that causes mild to severe gastrointestinal disorders and death in the elderly, immune compromised individuals and those exposed to systemic antibiotics. Increased recurrence and difficulties …
PAUL JOSEPH UTZ · STANFORD UNIVERSITY · 2024 · $133,135 — PROJECT SUMMARY/ABSTRACT The overarching goal of this R21 proposal is to test the hypothesis that DNA vaccines induce durable innate memory in HIV-infected humans by characterizing the evolution of the epigenetic and transcriptional landscape in subjects who have been immunized using a novel HIV DNA…
CHIUNG-YU HUNG · UNIVERSITY OF TEXAS SAN ANTONIO · 2024 · $1,357,000 — Summary (Overall) San Antonio has a rich tradition of excellence in the field of Medical Mycology, including Coccidioidomycosis, also referred to as Valley Fever. These infections affect hundreds of thousands of healthy and immunocompromised individuals in the endemic areas of the arid Southwest U.S…
Elias Sayour · UNIVERSITY OF FLORIDA · 2024 · $617,119 — Project Summary: Despite standard of care with maximal surgical resection, external beam radiotherapy, and chemotherapy, patients with glioblastoma (GBM) live little more than 18 months after diagnosis; these outcomes necessitate development of new targeted therapies. To address this gap, our group …
Gaurav Das Gaiha · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $859,455 — Modified Project Summary/Abstract Section The development of a prophylactic vaccine for HIV would benefit from the generation of immunogens and vaccine delivery modalities that can induce a combination of highly functional CD8+ T cell responses towards mutation constrained epitopes and broadly neutr…
BALI PULENDRAN · STANFORD UNIVERSITY · 2024 · $2,168,222 — ABSTRACT – Overall Component In the current proposal we will use a systems vaccinology approach to address two fundamental issues in vaccinology. The first issue concerns the immunology of COVID-19 vaccines, which utilize novel platforms (mRNA) or adjuvants (Matrix M used in the Novavax vaccine). Th…
Kristina De Paris · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $1,370,057 — ABSTRACT – Overall Nearly 600,000 new HIV infections occur yearly in adolescents/young adults (ages 15-24 years), the only population in which HIV infections continue to rise. The end of the HIV/AIDS epidemic will be achievable only when an effective vaccine regimen can elicit long-term protective i…
Richard John Martin · IOWA STATE UNIVERSITY · 2024 · $469,119 — Project Summary Filariases are a group of neglected tropical diseases produced by infection with microfilaria of Clade III parasitic nematodes that are transmitted by biting insects. One example is the lymphatic filariasis produced by Brugia malayi. Lymphatic filariasis is a debilitating and disfigu…
Jonathan Lawton · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $32,456 — PROJECT SUMMARY Despite decades of research, Plasmodium falciparum malaria continues to kill hundreds of thousands of children in sub-Saharan Africa each year. Vulnerability to severe malaria is complex, involving both host and parasite factors. Blood type A is an established risk factor for severe …
Swaminathan Smita Iyer · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $737,761 — Project Summary This proposal aims to enhance HIV prevention with a vaccine approach that promotes durable immunity. The studies center on CD4 T helper cells within lymph nodes, crucial for humoral and cytolytic memory. Our objective is to induce robust CD4 T follicular helper (Tfh) cells as they ar…
MAHADEVAN Raj RAJASEKARAN · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · 2024 · $215,250 — ABSTRACT Fecal incontinence (accidental leakage of stools; FI) is a major medical illness, occurs in a significant population of women (>7%) and is under reported. Most common cause of FI is childbirth related injury to the external anal sphincter (EAS), pelvic floor muscles and pudendal nerve (PN) …