Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Olivia Swanson · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $35,974 — Project Summary/Abstract. A small fraction of individuals infected with HIV-1 generate antibodies that can potently neutralize diverse circulating strains of HIV-1. Such broadly neutralizing antibodies (bnAbs) have provided sterilizing immunity in passive immunization studies in animal models. There…
Troy Michael Bankhead · WASHINGTON STATE UNIVERSITY · 2024 · $382,500 — Summary The ability of Borrelia burgdorferi to cause Lyme disease is highly dependent on its capacity to establish a successful infection upon entering the mammalian host. Moreover, survival of the pathogen in nature is completely dependent on its enzootic life cycle involving both a tick and reser…
ELLIS L REINHERZ · DANA-FARBER CANCER INST · 2024 · $640,540 — ABSTRACT Programming the immune system to detect neoantigens and destroy tumors is critical for effective immunotherapy. Until now, bioinformatic prediction of neoepitopes on tumors from Next Generation Sequencing (NGS) information has been used alone or in conjunction with immunological assays to i…
ERIC T. KOOL · STANFORD UNIVERSITY · 2024 · $623,371 — Work in the last decade from many labs has underlined the critical importance of RNA-mediated cellular pathways, and clear connections of specific RNAs to human health. RNAs are increasingly viewed both as appealing therapeutic targets, and as therapeutic agents themselves. We hypothesize that obtai…
Genoveffa Franchini · DIVISION OF BASIC SCIENCES - NCI · 2024 · $2,580,801 — Development of a vaccine for HIV is necessary as 38 million people are now infected worldwide, including 1.1 million in the US. The annual estimated HIV incidence is 1.5 million global infections per year, with 38,000 in the US. Moreover, adolescent girls and women are heavily impacted by the virus …
Lbachir BenMohamed · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $409,999 — SUMMARY/ABSTRACT Herpes simplex type virus-1 (HSV-1) infects over 3.72 billion people worldwide, including 200 million individuals in the United States. Following primary infection of the cornea, HSV-1 establishes latency in sensory neurons of the trigeminal ganglia (TG). Reactivation of HSV-1 from …
Pranav Danthi · TRUSTEES OF INDIANA UNIVERSITY · 2024 · $379,747 — Mammalian orthoreovirus (MRV) genomic RNA is detected by host cells to induce an innate immune response. Detection of MRV RNA also contributes to the induction of cell death. Because viral genomic RNA remains contained within particles throughout infection, how the RNA becomes exposed and accumulate…
Robert L. Ferris · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $250,000 — Optimization of a modified immunotherapeutic LANA antigen for use in treating persons with HIV/AIDS and refractory KSHV-related cancers (Immuno/Microenvironment). ABSTRACT This PA-20-272 administrative supplement to the UPMC Hillman Cancer Center Support Grant (P30CA047904) is directly responsive to…
David Anthony Hendrix · OREGON STATE UNIVERSITY · 2024 · $304,159 — PROJECT SUMMARY: There is a need for integrative data analyses that anchor transcriptomic research in contexts predictive of human health, as illustrated by growing awareness of disease-associated synonymous transcript variants and RNA biotechnologies such as mRNA vaccines. To help uncover sequence …
Siyuan Ding · WASHINGTON UNIVERSITY · 2024 · $393,750 — Project Summary Rotaviruses (RVs) are a medically important human pathogen and the predominant cause of severe gastroenteritis, vomiting, and diarrhea in infants and young children worldwide. RVs are also a great model to interrogate the antiviral responses at the host mucosal surfaces. Our overall…
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $3,442,683 — Neutralizing antibodies are likely to be required for an effective HIV-1 vaccine. However, few candidate vaccines efficiently elicit broadly neutralizing antibodies (bNAbs) following vaccination. Recently, the VRC working group has elicited fusion peptide-directed bNAbs in guinea pigs and non-human …
Zhi Q. Yao · JAMES H QUILLEN VA MEDICAL CENTER · 2024 — SUMMARY The overall goal of this proposal is to elucidate the mechanisms by which chronic HIV infection promotes telomere attrition and T cell aging, leading to hepatitis B virus (HBV) vaccine hypo-responsiveness. To this end, we will use a model that emulates HBV vaccine response in the setting of …
Sean PJ Whelan · WASHINGTON UNIVERSITY · 2024 · $561,330 — This application is to extend a MERIT award to study RNA synthesis in minus-strand RNA viruses. Nonsegmented negative-sense (NNS) RNA viruses include some of the most significant human pathogens that are an ongoing threat to US public health. For measles, mumps and rabies there are licensed vaccines…
Mehul Shamal Suthar · EMORY UNIVERSITY · 2024 · $752,750 — Humoral immunity is an essential component of the immune response to flavivirus infection. Primary infection generates a robust neutralizing antibody response that mediates viral control and protection. It is becoming increasingly apparent that secondary infection with a closely related flavivirus s…
Qingsheng Li · UNIVERSITY OF NEBRASKA LINCOLN · 2024 · $650,156 — Summary Novel vaccine strategies is needed to develop a safe, effective, and broadly accessible HIV vaccine to end the HIV pandemic. This proposal is built upon several innovative advancements. First, learned from natural immunity observed in a group of HIV resistant Kenyan female sex workers, we fo…
MICHAEL N STARNBACH · HARVARD MEDICAL SCHOOL · 2024 · $205,449 — Chlamydia trachomatis is an obligate intracellular bacterium and the most prevalent sexually transmitted infection in the United States. If untreated, infection can lead to pelvic inflammatory disease, ectopic pregnancy, and infertility. Although C. trachomatis infection is treatable with antibiotic…
Nicolas Wentzensen · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · 2024 · $535,504 — The following research projects are etiologic and human population based and all have various molecular components: SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at…
Lisa Jenkins · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,295,034 — Overall, the expertise of the Mass Spectrometry Resource is being used to further the research of multiple groups within the NIH. In FY24, we collaborated in more than 65 different projects from 40 different investigators, with over 4000 sample runs. Among these are projects to characterize the post…
Patrick Duffy · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $800,611 — In FY2024, we reported human and animal studies to investigate malaria immunology and pathogenesis, and malaria vaccine development. Highlighted in this year’s summary are results from our publications. Miotto O et al. Identification of complex Plasmodium falciparum genetic backgrounds circulating…
James M Dubois · WASHINGTON UNIVERSITY · 2024 · $458,341 — Religion is a primary driver of concerns with genomics and genomic healthcare (GGH). It is vital for research on the ethical, legal, and social implications (ELSI) of genomics to understand the role of religion in shaping public attitudes toward GGH. Ninety percent of the US public believes in some …