Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
DAVID BAKER · UNIVERSITY OF WASHINGTON · 2023 · $703,773 — PROJECT SUMMARY One of the most pressing public health priorities for the COVID-19 pandemic is the development of an effective and inexpensive therapeutic. The long-term goal of this proposal is to develop such COVID-19 treatments, as well as the methods needed to rapidly create such molecules as so…
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2023 · $431,960 — Project Summary/Abstract: Our discovery that the NGLY1/PNG-1 deglycosylation enzyme mediates the protein editing of N- glycosylated asparagines to aspartic acid of the SKN-1A transcription factor to increase proteasomal capacity is highly relevant to protein aggregation diseases, such as Alzheimer’s…
Marisa L. Zallocchi · CREIGHTON UNIVERSITY · 2023 · $520,111 — ABSTRACT. An organism’s perception of its surrounding environment depends on the sensory function. Neurosensory cells from the inner ear are involved in key biological processes associated with hearing and balance. To be able to achieve their function these cells depend on a complex array of membran…
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2023 · $748,825 — PROJECT SUMMARY Vaccines represent a highly effective public health measure to protect individuals from infectious diseases. Many vaccines work by inducing antigen-specific antibodies that neutralize the pathogen or its products and promote their clearance. Vaccines based on protein antigens usually…
Chao Wang · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2023 · $189,242 — Project Summary/Abstract As of mid June 2021, the new coronavirus disease (COVID-19), caused by SARS-CoV-2 virus, has infected ~180 million people and causing ~3.8 million deaths globally. There are more than 34 million confirmed cases and ~620,000 deaths in the U.S alone. The fast transmission, as…
Daniel A Hammer · UNIVERSITY OF PENNSYLVANIA · 2023 · $203,125 — Summary Severe respiratory acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a world-wide pandemic causing over 525K deaths in the U.S. and over 2.6M deaths world-wide as of this writing. Here, we propose to make phospholipid vesicles and other related nanostructures (d…
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2023 · $353,000 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination is safe, immunogenic, and durable in individuals with treated and virally suppressed HIV infection but is less immunogenic in immunosuppressed individuals and those with unsuppressed HIV infection. The rollout of COVID-19 vaccines is still limited in cou…
Adrianus CM Boon · WASHINGTON UNIVERSITY · 2023 · $581,630 — PROJECT SUMMARY SARS-CoV-2 has led to unprecedented disruptions to society, killing more than 6 million people worldwide. It is a respiratory virus whose main mode of transmission is via respiratory droplets and aerosols. Social distancing and vaccines have greatly decreased the rate of infection an…
Siyuan Ding · WASHINGTON UNIVERSITY · 2023 · $233,250 — Rotavirus (RV) is a major etiological cause of severe gastroenteritis and diarrhea worldwide, resulting in the death of more than 200,000 children each year. Current RV vaccines have limited efficacy in endemic countries and no direct antivirals are available. Our overall objective is to better unde…
Amit Praful Khandhar · HDT BIO CORPORATION · 2023 · $940,253 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
MANOJ K PATEL · UNIVERSITY OF VIRGINIA · 2023 · $399,015 — Epilepsy is a major economic and personal burden for the American public, affecting over 3 million Americans (1-2% of the population) with over 200,000 new cases diagnosed each year. There is no cure for epilepsy. Seizures can only be suppressed using antiepileptic drugs. Unfortunately, these drugs …
YUYING LIANG · UNIVERSITY OF MINNESOTA · 2023 · $232,500 — Abstract The COVID-19 pandemic has had a profound, global impact on public health. Of the 120,000,000 cases documented world-wide, over 30 million cases have occurred in the Unites States, with >530,000 COVID deaths to date. Considerable progress in control of the pandemic has been realized in the U…
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2023 · $628,260 — PROJECT SUMMARY Generating an appropriate antibody response is critical for protection against reinfection and for the effectiveness of vaccination, particularly in the context of viral diseases. In addition to well-studied quantitative parameters such as antibody titer and affinity, other, more qua…
Hideki Aihara · UNIVERSITY OF MINNESOTA · 2023 · $619,646 — Abstract Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest is retroviral integration, a critical step in the lifecycle o…
Kiesha Wilson · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2023 · $62,501 — PROJECT SUMMARY/ABSTRACT The virus, SARS-CoV-2 has caused COVID-19 and claimed the lives of over 240,000 Americans and 1,270,000 people worldwide. Severe cases of the disease leads to Acute Respiratory Distress Syndrome (ARDS), sepsis and can be fatal due to pulmonary inflammation and destruction of…
Franklin Caval-Holme · BOSTON CHILDREN'S HOSPITAL · 2023 · $69,500 — PROJECT SUMMARY/ABSTRACT When faced with a visual scene, the brain encodes both image detail and the scene’s overall intensity, measured as irradiance. Encoding irradiance is critical for circadian regulation, pupil constriction, and image vision, among other important functions. A canonical feature…
Andrew Laurence Routh · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $171,291 — RNA viruses are exceptionally diverse and rapidly evolving. Their RNA-dependent RNA polymerases are prone to mutation, lack proof-reading capabilities (with the unique exception of coronaviruses) and frequently undergo recombination between both homologous and non-homologous templates. This confers …
Mark L Baccei · UNIVERSITY OF CINCINNATI · 2023 · $606,669 — Project Summary/Abstract Long-term potentiation (LTP) of primary afferent synapses onto spinal projection neurons (PNs) has been linked to increased pain sensitivity. The timing rules controlling the generation of LTP in adult PNs can be persistently relaxed by neonatal tissue damage, which likely …
Rongsheng Jin · TUFTS UNIVERSITY BOSTON · 2023 · $865,682 — ABSTRACT In previous NIH sponsored research we successfully tested the hypothesis that integrating structural and mechanistic information into heteromultimeric VHH-based neutralizing agent (VNA) design facilitated development of antitoxins with even greater efficacy and versatility. In this renewal …
Vijaya Mohan Rao Lella · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · 2023 · $220,500 — Emerging evidence indicates that the novel SARS-CoV-2 infection is associated with a high incidence of thrombotic complications. Thrombotic complications in COVID-19 patients are found to be life-threatening. Elevated D-dimers and disseminated intravascular coagulation (DIC) are strong predictors of…