Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
You Li · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $233,250 — PROJECT SUMMARY/ABSTRACT Hepatitis A virus (HAV), a plus-strand virus classified in the Picornaviridae, is a common cause of acute hepatitis. Despite the availability of vaccines, striking increases in the incidence of hepatitis A have led to increasing numbers of deaths associated with severe infec…
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2021 · $753,206 — Abstract Influenza is responsible for significant morbidity and mortality worldwide every year and causes severe pandemics when new strains evolve that have not previously circulated in humans. The high viral mutation rate necessitates that new vaccines be generated based on the prevalence of circul…
Sujan Shresta · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2021 · $712,699 — ABSTRACT The long-term goal of this project is to develop a dengue-Zika vaccine that provides protection against the four serotypes of dengue (DENV1-4) and Zika (ZIKV) viruses with maximal safety and efficacy. To date, flavivirus vaccine development has focused on the induction of neutralizing antib…
Justin Richner · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $454,113 — Nearly 400 million people are infected with dengue virus (DENV) each year through the bite of infected mosquitos concentrated in the tropical and subtropical regions of the world. Symptoms can range from febrile illness to severe dengue that manifests as plasma leakage, sudden loss of blood pressure…
PAUL L FOX · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $402,500 — Project Summary/Abstract Obesity is an epidemic-scale problem in the U.S. affecting about 35% of the adult population, and is a major risk factor for the ongoing pandemic, COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA betacoronavirus that is the causative agent of…
Natalie Lea Silver · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $155,304 — PROJECT SUMMARY/ABSTRACT Oral cavity squamous cell carcinoma (OCSCC) is a very aggressive and deadly disease with poor survival rates following maximal treatments such as surgery and chemoradiotherapy. The immunosuppressive tumor microenvironment (TME) is a major barrier of response to traditional …
Patrizia Farci · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $47,482 — Screening of more than 120 convalescent patients from COVID-19, recruited at the NIH Blood Bank, identified 15 sera with high titers of neutralizing antibodies against SARS-CoV-2. Whole blood from these 15 donors was processed (isolation of PBMCs, B-cell purification, extraction of mRNA, cDNA synthe…
RICHARD J. HODES · DIVISION OF BASIC SCIENCES - NCI · 2021 · $706,073 — We investigated the function of tumor suppressor p53 in regulating proliferation and function of T lymphocytes. We have made the unexpected observation that antigen-specific proliferative responses of naive and memory CD4 T cells require the down-modulation of tumor suppressor p53. In the absence of…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,300,391 — An ideal HIV vaccine should provide protection against all HIV-1 variants. Thus, an important aspect of HIV vaccine development is the selection of immunogens, which has to take into consideration the diversity of the different HIV clades and the identification of the critical epitopes able to induc…
George N. Pavlakis · DIVISION OF BASIC SCIENCES - NCI · 2021 · $661,794 — A collection of human samples is being analyzed to examine in detail humoral and cellular immunity after natural infection. These patients recovered from infection and accepted to donate convalescent plasma for transfer to hospitalized patients in an approved clinical trial. The immune response of t…
Mary N. Carrington · DIVISION OF BASIC SCIENCES - NCI · 2021 · $100,619 — We are currently performing genetic analyses of several COVID-19 cohorts. These studies are important for design of vaccines and potentially as biomarkers for therapeutic interventions. We are also participating in the COVID-19 Host Genetics Initiative, a collaboration among the human genetics commu…
Elizabeth Conner · DIVISION OF BASIC SCIENCES - NCI · 2021 · $2,473,796 — CCR Genomics Core lists over 1800 registered members in its iLab management and scheduling software. So far in 2021 there are 450 active users; 172 research groups of which 142 are from NCI and the remaining 30 from 7 other NIH institutes. These institutes include NIAID, NEI, NINDS, NHLBI, NIDDK, NI…
Nicolas Wentzensen · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · 2021 · $376,904 — The following research projects are etiologic and human population based and all have various molecular components:SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at …
RICHARD CHILDS · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $1,570,973 — Approximately 20 years ago, we initiated the first ever clinical trail investigating allogeneic stem cell transplantation in patients with treatment refractory metastatic renal cell carcinoma (RCC). Definitive evidence for an allogeneic graft-versus-RCC effect has been demonstrated with complete reg…
paolo lusso · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $1,665,552 — The development of a protective and/or therapeutic HIV vaccine has been hampered by unprecedented challenges, primarily due to the unique properties of the HIV-1 envelope (Env) trimer, a cleverly engineered entry machinery that features an extraordinary assortment of immune-evasion tactics, includin…
T. Jake Liang · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2021 · $726,910 — HCV dependencies on the host machinery are both intricate and extensive. Each of these host dependencies is a potential therapeutic target. Previous efforts have been successful in discovering important steps in HCV replication, yet many fundamental processes in the viral life cycle remain uncharact…
CHRISTOPHER P. HILL · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $400,365 — ABSTRACT The success of antiretroviral therapy (ART) has transformed the HIV/AIDS pandemic into a life-long chronic disease, yet major challenges remain as a growing population of ~35 million patients living with HIV continues to face significant health challenges. These include side-effects and tox…
Mathias Lichterfeld · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2021 · $223,467 — Project Summary/Abstract, Immune Control (Project 4) Finding a cure for HIV-1 infection is of particular importance for the growing number of HIV-1-infected infants, children and teenagers who will have to take lifelong antiretroviral therapy if curative treatment options will not be available. Rece…
GARRY P NOLAN · STANFORD UNIVERSITY · 2021 · $293,948 — PROJECT SUMMARY New technologies such as mass cytometry have greatly expanded our ability to deepen our understanding of the complexity of lymphocytes and related populations. The Stanford CCHI group has been particularly attuned to the potential in following the lead of the Nolan lab in exploiting …
Matthew Adrian Coleman · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · 2021 · $383,595 — ABSTRACT Throughout the world Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterial pathogen. In countries with poor sanitary conditions ocular infections with Ct can result in trachoma, the most frequent cause of preventable blindness worldwide. Based on protection and serolo…