Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
CATHERINE MARY O'CONNELL · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $117,278 — In a subset of Chlamydia trachomatis-infected women, the infection escapes immune control and ascends to the upper reproductive tract. There is a fundamental gap in understanding how pathways activated by chlamydial infection lead to immune pathology and reproductive morbidity in women. Its continue…
Barton F. Haynes · DUKE UNIVERSITY · 2021 · $3,622,426 — Administrative Core The IPCAVD Administrative Core will serve to coordinate all scientific and administrative activities of the Duke IPCAVD, ensuring that the Projects and Cores function well together. A primary activity of the Core will be monitoring IPCAVD progress relative to milestones and measu…
Thomas Denny · DUKE UNIVERSITY · 2021 · $3,489,292 — HIV vaccine candidates entering into clinical testing generally fall into three categories: 1) recombinant envelope (Env) protein immunogens, 2) viral vectors, and 3) plasmid DNA. Numerous vaccine Env designs are being tested in clinical trials. Likewise, numerous HIV vaccine inserts, such as mosaic…
SAM ON HO · MOLECULAR EXPRESS, INC. · 2021 · $299,994 — Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines: Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, self-amplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery …
CHINTHALAPALLY RAO · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2021 · $845,841 — It has been shown that the extracellular domain of human anti-Müllerian hormone receptor type II (AMHR2-ED) is a prototypic ‘retired’ tissue-specific protein that may serve as a vaccine target for primary immunoprevention of epithelial ovarian cancer. AMHR2 is a serine/threonine kinase receptor homo…
Hiten D Madhani · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $620,877 — Objective: We propose to construct and distribute a series of SARS-CoV-2-derived molecular clones using powerful genome assembly and rapid CRISPR-based manipulation methods available in the yeast Saccharomyces cerevisiae. We will develop and apply methods to mutate and tag each of the 18 viral prote…
HANA M EL SAHLY · BAYLOR COLLEGE OF MEDICINE · 2020 · $5,921,655 — ABSTRACT This supplement request is for a Phase 3, randomized, stratified, observer-blind, placebo- controlled study to evaluate the efficacy, safety and immunogenicity, of mRNA-1273 vaccine compared to placebo in adults 18 years of age and older who have no known history of SARS- CoV-2 infection bu…
Siyuan Ding · WASHINGTON UNIVERSITY · 2020 · $393,125 — Project Summary Rotaviruses (RVs) are a medically important human pathogen and the predominant cause of severe gastroenteritis, vomiting, and diarrhea in infants and young children worldwide. RVs are also a great model to interrogate the antiviral responses at the host mucosal surfaces. Our overall…
BRUNO DE BEZERRIL ANDRADE · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $972,111 — PROJECT SUMMARY Recent studies from our group have reported a peripheral blood correlate of risk (COR) transcriptional signature that identified individuals with incipient (asymptomatic) TB who progressed to active (symptomatic) TB disease within 12 months. We have also identified human genetic poly…
Patricia DEVAUX · MAYO CLINIC ROCHESTER · 2020 · $318,000 — Abstract. The recent advances in induced pluripotent stem cells (iPSCs) and gene therapy tools have opened up a new avenue to study and treat diseases, particularly of disorders with defective bone marrow. Bone marrow failure syndromes (BMFS) are characterized by reduced blood cells due to a dysfunc…
Toni Darville · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $795,093 — DESCRIPTION (provided by applicant): Chlamydia trachomatis infection is the leading cause of infertility and ectopic pregnancy in women. Infection is often asymptomatic, leading to lack of detection, increased risk for disease and delay in treatment. Although antibiotic therapy eliminates infec…
Dipak Kumar Raj · BROWN UNIVERSITY · 2020 · $400,000 — Project Summary The overall aim of this application is to advance PfCDPK5 and PfGARP as vaccine candidates for falciparum malaria. P.falciparum malaria affects almost one-half of the world's population and causes more than 500,000 deaths annually. Young children in malaria endemic areas of Africa h…
Kimberly D. Klonowski · UNIVERSITY OF GEORGIA · 2020 · $188,750 — Abstract Identifying the mechanisms that regulate CD8 T cell responses is critical for improving anti-viral and anti-tumor vaccine efficacy and is currently an area of intense investigation due to the profound implications for improving human health. The goal of this application is to determine the …
Sean PJ Whelan · WASHINGTON UNIVERSITY · 2020 · $560,736 — This application is to extend a MERIT award to study RNA synthesis in minus-strand RNA viruses. Nonsegmented negative-sense (NNS) RNA viruses include some of the most significant human pathogens that are an ongoing threat to US public health. For measles, mumps and rabies there are licensed vaccines…
John T Chang · VA SAN DIEGO HEALTHCARE SYSTEM · 2020 — DESCRIPTION (provided by applicant): Mortality from chronic infectious diseases, including Hepatitis C, HIV, and tuberculosis, remains a major problem among Veterans, making the development of new vaccines an important priority of biomedical research. Immunologic memory is a cardinal fea…
Rong Xu · PROFECTUS BIOSCIENCES, INC. · 2020 · $69,471 — Abstract Profectus Biosciences leverages its platform technologies of adjuvanted DNA vaccines to stimulate robust Th1- biased immune responses likely necessary for protection against challenging viral diseases such as HIV. We believe that optimized delivery methods are critical for development of ef…
SAUL r TZIPORI · TUFTS UNIVERSITY BOSTON · 2020 · $247,500 — We seek NIH funding to develop a vaccine against cryptosporidiosis for children in LMIC. As no effective therapies exist, there is a critical need for vaccination to reduce morbidity and mortality attributed to cryptosporidiosis, which is estimated to cause diarrhea in >10 million children and kills…
David M Koelle · UNIVERSITY OF WASHINGTON · 2020 · $563,301 — Project Summary: The waning of immunity has a major impact on morbidity and mortality in the aged. Antigen-specific, acquired, and especially T-cellular is important in host defense against chronic intracellular pathogens and cancer. Infections with these microbes and skin cancers with high mutation…
Elias Sayour · UNIVERSITY OF FLORIDA · 2020 · $158,188 — Abstract: I am now in my first faculty position as an Assistant Professor of Neurosurgery and Pediatrics at the University of Florida. I completed a T32 NIH fellowship at Duke University in Cancer Biology and Developmental Therapeutics before accepting a junior faculty position at the University of …
Michael S Diamond · WASHINGTON UNIVERSITY · 2020 · $956,340 — PROJET SUMMARY/ABSTRACT Globally, the four serotypes of DENV cause an estimated 390 million new cases of dengue fever and 500,000 cases of dengue hemorrhagic fever (DHF) per year. Zika virus (ZIKV) is a related emerging virus linked to Guillain-Barre syndrome in adults, and microcephaly, congenital …