NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
WEI WENG · INGENIOUS TARGETING LABORATORY, INC. · 2021 · $297,204 — With the initial wave of zoonotic transmission firmly established in the human population worldwide, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) poses an eminent threat to individuals, health care systems and societies. Various degrees of disease severity (from asymptomatic …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
ROBERTO G BACCALA · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · 2021 · $423,965 — Project Summary COVID-19 caused by the novel coronavirus SARS-Cov-2 first emerged in December 2019 and was officially declared a pandemic by WHO in March 2020. During this time, COVID-19 has caused millions of cases and deaths across the world. While most cases are asymptomatic or present with mild …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Ping Wang · MICHIGAN STATE UNIVERSITY · 2021 · $430,375 — ABSTRACT The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic with significant morbidity and mortality. Despite widespread efforts, it's far from certain that an effective vaccine will be…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
ANTHONY W ORVEDAHL · WASHINGTON UNIVERSITY · 2021 · $1,410,500 — PROJECT SUMMARY/ABSTRACT The host inflammatory response is a double-edged sword that must vigorously defend against pathogens, but also requires restraint to prevent unintended injury to the host. The Cytokine Storm Syndrome (CSS) represents a state of unbridled inflammation that can be triggered b…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
YOSHIHIRO KAWAOKA · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $194,375 — PROJECT SUMMARY The pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus can cause severe and even fatal infections in some patients, primarily those with comorbidities such as hypertension, diabetes mellitus, obesity, and cardiovascular disease. In addition, immunocompromise…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Rihe Liu · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $224,925 — Abstract The Covid-19 pandemic caused by SARS-Cov-2 has resulted in 38.3 million infection cases across 188 countries and territories with more than 1.08 million deaths by October 14 2020. While various vaccines are under expedite development, there is a serious concern that future variants of SARS…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
CALVIN J KUO · STANFORD UNIVERSITY · 2021 · $393,625 — ABSTRACT The COVID-19 pandemic, engendered by the novel coronavirus SARS-CoV-2, is a grave threat to public health, with lung infection and respiratory failure. However, the intestine is also targeted by SARS-CoV-2, as many patients present with GI symptoms and the SARS-CoV-2 receptor angiotensin-co…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
George Ueda · UNIVERSITY OF WASHINGTON · 2021 · $308,875 — Broader Impacts: The current COVID-19 outbreak is a global pandemic with over 45 million cases and 1,200,000 deaths officially reported. Epidemiological data emerging from Italy indicate that 40-96% of COVID- 19 patients admitted into the hospital develop ARDS and sepsis. Developing a functional tre…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Tian Jin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $64,404 — We have started the project Identification of co-receptor and components involved in the entry of SARS-CoV-2 using a quantitative phosphoproteomic approach. We developed a mass-spectrometry method to detect changes of protein phosphorylation in live cells upon stimulations. This method combines ta…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Marshall Elliott Bloom · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $8,717 — Since early 2020, the COVID-19 pandemic, caused the novel -coronavirus SARS-CoV-2, has ravaged the world and has disrupted much biomedical research. Consequently, we decided to focus a portion of our efforts on human coronaviruses, like SARS-CoV-2 and the Middle East Respiratory Syndrome coronavirus…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
John Schneekloth · DIVISION OF BASIC SCIENCES - NCI · 2021 · $148,693 — Traditional drug screening strategies are based on targeting coronavirus-related proteins (e.g., RdRp, Mpro, and 3CLpro) and receptors (e.g. ACE2). In addition to virus-coded proteins, RNA structures within the SARS-CoV-2 genome also regulate essential functions and are potentially attractive and co…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Tongqing Zhou · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $606,667 — The SARS-CoV-2 pandemic has caused more than 220 million confirmed infections and almost 4.5 million deaths globally. Great efforts have been made for the development of vaccines and therapeutics. Isolation of virus-neutralizing monoclonal antibodies could be one approach to treat or prevent infecti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
leping li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,040,862 — Project 1: Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines Studies that characterize human cancer cell lines and evaluate their sensitivity to drugs provide valuable information about the therapeutic potential and the possible mech…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Monica Kraft · UNIVERSITY OF ARIZONA · 2021 · $371,166 — During the first cycle of our AADCRC program, our project focused primarily on Surfactant Protein A (SP-A), a known innate immune modulator that exhibits important anti-inflammatory effects in asthma. In this renewal, we show preliminary data that SP-A binds the interleukin (IL)-6 receptor and disru…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Megan Sykes · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $283,116 — Project Summary: There is growing evidence that an overexuberant innate and adaptive immune response may contribute to life-threatening pulmonary pathology in COVID-19 disease. On the other hand, inadequate viral control may allow severe disease to develop. Human immune system (HIS) mouse models hav…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Helene D Benveniste · STATE UNIVERSITY NEW YORK STONY BROOK · 2020 · $463,521 — ABSTRACT SARS-CoV-2 contact with the organism starts with binding to its key receptor ACE2 which is highly expressed in the ciliated cells of the tracheal, bronchial, and nasal mucociliary epithelium. After binding, the virus inhibits the cilia beating in the airways and suppresses mucociliary trans…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Jochen Reiser · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $459,623 — ABSTRACT From early studies and published reports indicate kidney injury is one of the manifestations of COVID-19. The human kidney is a direct target of the virus, as the angiotensin-converting enzyme 2 (ACE2), a putative receptor for SARS-CoV-2, is highly expressed in the kidney tubules. As direct…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
RICHARD A GIBBS · BAYLOR COLLEGE OF MEDICINE · 2020 · $100,000 — OVERALL PROJECT SUMMARY The novel coronavirus, SARS-CoV-2, that was first detected in China in December 2019 has now spread globally. The Texas Medical Center in Houston, TX, the fourth largest city in the US, and among the top 10 in racial diversity, mounted an aggressive early response to the pand…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
KATHLEEN E. RODGERS · UNIVERSITY OF ARIZONA · 2020 · $1,533,089 — PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a progressive multifactorial disease affecting more than 50 million people worldwide, and is the most common dementia of late-life. To date, no interventions have demonstrated substantial therapeutic efficacy to prevent, delay or treat AD. In rece…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2020 — With prevalence higher than 33% in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. According to the Veterans’ Affairs (VA) Office of Research & Developmen…