NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2020 · $404,754 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
ROBERT M LAVKER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $410,000 — PROJECT SUMMARY/ABSTRACT The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying structures from injury, in part, through the elaboration of the limbal and corneal epithelia. It is well- accepted that the limbal epithelium is the site o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Jamie M Verheyden · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $434,000 — PROJECT SUMMARY The COVID19 pandemic has spread across the globe with unprecedented speed and devastation. With infected individuals rising past 1.4 million in the US, there is a dizzying amount of information causing confusion around which tissues SARS-CoV-2 infects and how it triggers catastrophi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2020 · $312,700 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Nadejda Mincheva Tsankova · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $339,000 — SUMMARY Coronavirus disease 2019 (COVID19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a global pandemic, causing overwhelming morbidity and mortality. While the main manifestations of COVID19 relate to problems with respiration, emerging studies recognize…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Shyam Biswal · JOHNS HOPKINS UNIVERSITY · 2020 · $450,313 — It is estimated that while the majority of SARS-CoV2 infections in the ongoing coronavirus disease-2019 (COVID-19) pandemic are asymptomatic or have mild symptoms, hospitalizations and mortality largely occurs in patients with co-morbid conditions such as obesity, diabetes and COPD. Our understandin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Thomas Hope · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $786,043 — Summary: The current pandemic of COVID-19 has rapidly spread around the world infecting millions and killing more than 200,000 people in just months. The first wave of the pandemic is currently peaking in the United States causing almost 60,000 deaths in the past 6 weeks. This highly contagious viru…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2020
Heather Hickman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $258,827 — The emergence of SARS-CoV-2 in human populations in 2019 has resulted in a global pandemic with staggering morbidity and mortality. In humans, coronavirus-induced disease 2019 (COVID-19) is characterized by decreased lung function and increased pro-inflammatory cytokine production. As the immune m…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
ROBERT M LAVKER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $410,000 — PROJECT SUMMARY/ABSTRACT The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying structures from injury, in part, through the elaboration of the limbal and corneal epithelia. It is well- accepted that the limbal epithelium is the site o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Elizabeth Gray · UNIVERSITY OF HOUSTON · 2019 · $34,186 — Abstract The increasing world-wide prevalence of obesity is a worrying public health problem and crisis. Coexistence of obesity, hypertension and diabetes significantly increases the risk of kidney dysfunction. In obesity, concentrations of angiotensin II (Ang II) increase, while those of Ang-(1-7) …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2019 · $403,279 — This proposal examines the hypothesis that diabetes results in a pathological change in the communication between the bone marrow (BM) and gut leading to dysfunction in both compartments. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (ANG II) to angiotensin 1-7(Ang 1-7) which, by vi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2019 — With prevalence higher than 33% in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. According to the Veterans’ Affairs (VA) Office of Research & Developmen…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Irving H Zucker · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2019 · $437,136 — PROJECT SUMMARY/ABSTRACT Chronic heart failure (CHF) affects a growing number of Americans. This disease is one of the leading causes of death and disability in the developed world. In order to develop new therapies for this disorder a comprehensive understanding of the pathogenesis and mechanisms b…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Eric Gerald Krause · UNIVERSITY OF FLORIDA · 2019 · $381,250 — Project Summary Stressful life events contribute to the etiology of anxiety and hypertension and increase the risk for cardiovascular disease, which is the leading cause of death in the U.S. Despite a myriad of research, nearly one-third of patients with anxiety and/or hypertension are resistant to …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2019 · $413,160 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2019
Yagna Jarajapu · NORTH DAKOTA STATE UNIVERSITY · 2019 · $50,000 — Healthy cerebral vasculature and adequate blood flow determine overall brain health. Vascular cognitive impairment and dementia (VCID) has now been recognized as a clinical condition with cerebrovascular dysfunction as the underlying pathological mechanism. Aging and diabetes are independent risk fa…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kathryn Marie Jones · BAYLOR COLLEGE OF MEDICINE · 2024 · $781,984 — Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection Abstract: Chagas disease, caused by infection with the vector borne intracellular protozoal parasite Trypanosoma cruzi, affects approximately 6.5 million people worldwide. Chronic infection with T. cruz…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Yanmin Zhu · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $89,500 — Congenital cytomegalovirus (cCMV) infection is the most common congenital infection in the US, affecting one in every 200 infants each year. Approximately 10% of newborns impacted by cCMV have symptoms at birth, such as small size for gestational age, jaundice, petechiae/purpira, and hepatosplenomeg…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ROBERTO DOCAMPO · UNIVERSITY OF GEORGIA · 2024 · $226,500 — Abstract Cardiomyopathy is the most frequent clinical manifestation of Chagas disease. The pathogenesis of the heart disease is attributed to the persistence of T. cruzi leading to chronic inflammation, fibrosis, cardiac hypertrophy and heart failure. Fibrosis results from excessive accumulation of …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Maria Pilar Aoki · NATIONAL RESEARCH COUNCIL OF ARGENTINA · 2024 · $130,912 — Project Summary Chagas disease, a major public health problem in Latin America, is caused by the infection with the protozoan parasite Trypanosoma (T.) cruzi and has been spread to non-endemic regions by migratory movements. Chagas cardiomyopathy represents the most severe complication of chronic Ch…